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Multiple Instance Learning (MIL) has demonstrated promise in Whole Slide Image (WSI) classification. However, a major challenge persists due to the high computational cost associated with processing these gigapixel images. Existing methods…

Computer Vision and Pattern Recognition · Computer Science 2023-12-05 Hongyi Wang , Luyang Luo , Fang Wang , Ruofeng Tong , Yen-Wei Chen , Hongjie Hu , Lanfen Lin , Hao Chen

Multiple Instance Learning (MIL) has emerged as the best solution for Whole Slide Image (WSI) classification. It consists of dividing each slide into patches, which are treated as a bag of instances labeled with a global label. MIL includes…

Computer Vision and Pattern Recognition · Computer Science 2025-05-05 Ali Mammadov , Loic Le Folgoc , Julien Adam , Anne Buronfosse , Gilles Hayem , Guillaume Hocquet , Pietro Gori

In traditional multiple instance learning (MIL), both positive and negative bags are required to learn a prediction function. However, a high human cost is needed to know the label of each bag---positive or negative. Only positive bags…

Machine Learning · Computer Science 2016-03-17 Zhen Hu , Zhuyin Xue

The paper proposes a novel multi-class Multiple-Instance Learning (MIL) problem called Learning from Majority Label (LML). In LML, the majority class of instances in a bag is assigned as the bag-level label. The goal of LML is to train a…

Computer Vision and Pattern Recognition · Computer Science 2025-09-05 Shiku Kaito , Shinnosuke Matsuo , Daiki Suehiro , Ryoma Bise

In many real-world tasks, particularly those involving data objects with complicated semantics such as images and texts, one object can be represented by multiple instances and simultaneously be associated with multiple labels. Such tasks…

Machine Learning · Computer Science 2020-07-07 Sheng-Jun Huang , Zhi-Hua Zhou

Multiple instance learning (MIL) is a supervised learning methodology that aims to allow models to learn instance class labels from bag class labels, where a bag is defined to contain multiple instances. MIL is gaining traction for learning…

Computer Vision and Pattern Recognition · Computer Science 2019-11-14 Samuel W. Remedios , Zihao Wu , Camilo Bermudez , Cailey I. Kerley , Snehashis Roy , Mayur B. Patel , John A. Butman , Bennett A. Landman , Dzung L. Pham

We study the problem of learning from aggregate observations where supervision signals are given to sets of instances instead of individual instances, while the goal is still to predict labels of unseen individuals. A well-known example is…

Machine Learning · Statistics 2021-01-08 Yivan Zhang , Nontawat Charoenphakdee , Zhenguo Wu , Masashi Sugiyama

In-line with the success of deep learning on traditional recognition problem, several end-to-end deep models for zero-shot recognition have been proposed in the literature. These models are successful to predict a single unseen label given…

Computer Vision and Pattern Recognition · Computer Science 2018-03-19 Shafin Rahman , Salman Khan

Multiple Instance Learning (MIL) offers a natural solution for settings where only coarse, bag-level labels are available, without having access to instance-level annotations. This is usually the case in digital pathology, which consists of…

Computer Vision and Pattern Recognition · Computer Science 2026-01-21 Andreas Lolos , Stergios Christodoulidis , Aris L. Moustakas , Jose Dolz , Maria Vakalopoulou

The dynamic environment of laboratories and clinics, with streams of data arriving on a daily basis, requires regular updates of trained machine learning models for consistent performance. Continual learning is supposed to help train models…

Machine Learning · Computer Science 2025-08-12 Zahra Ebrahimi , Raheleh Salehi , Nassir Navab , Carsten Marr , Ario Sadafi

We address the problem of \emph{instance label stability} in multiple instance learning (MIL) classifiers. These classifiers are trained only on globally annotated images (bags), but often can provide fine-grained annotations for image…

Computer Vision and Pattern Recognition · Computer Science 2017-03-16 Veronika Cheplygina , Lauge Sørensen , David M. J. Tax , Marleen de Bruijne , Marco Loog

Not all supervised learning problems are described by a pair of a fixed-size input tensor and a label. In some cases, especially in medical image analysis, a label corresponds to a bag of instances (e.g. image patches), and to classify such…

Machine Learning · Computer Science 2021-03-08 Dawid Rymarczyk , Adriana Borowa , Jacek Tabor , Bartosz Zieliński

In this paper, we propose the MIML (Multi-Instance Multi-Label learning) framework where an example is described by multiple instances and associated with multiple class labels. Compared to traditional learning frameworks, the MIML…

Machine Learning · Computer Science 2011-10-28 Zhi-Hua Zhou , Min-Ling Zhang , Sheng-Jun Huang , Yu-Feng Li

Learning from Label Proportions (LLP) is a weakly supervised learning method that aims to perform instance classification from training data consisting of pairs of bags containing multiple instances and the class label proportions within…

Machine Learning · Computer Science 2023-02-22 Ryoma Kobayashi , Yusuke Mukuta , Tatsuya Harada

Multiple instance learning is qualified for many pattern recognition tasks with weakly annotated data. The combination of artificial neural network and multiple instance learning offers an end-to-end solution and has been widely utilized.…

Computer Vision and Pattern Recognition · Computer Science 2022-05-30 Jingjun Yi , Beichen Zhou

Multiple Instance learning (MIL) models have been extensively used in pathology to predict biomarkers and risk-stratify patients from gigapixel-sized images. Machine learning problems in medical imaging often deal with rare diseases, making…

Computer Vision and Pattern Recognition · Computer Science 2023-09-12 Dinkar Juyal , Siddhant Shingi , Syed Ashar Javed , Harshith Padigela , Chintan Shah , Anand Sampat , Archit Khosla , John Abel , Amaro Taylor-Weiner

The whole slide image (WSI) classification is often formulated as a multiple instance learning (MIL) problem. Since the positive tissue is only a small fraction of the gigapixel WSI, existing MIL methods intuitively focus on identifying…

Computer Vision and Pattern Recognition · Computer Science 2023-12-22 Wenhao Tang , Sheng Huang , Xiaoxian Zhang , Fengtao Zhou , Yi Zhang , Bo Liu

Weakly supervised machine learning algorithms are able to learn from ambiguous samples or labels, e.g., multi-instance learning or partial-label learning. However, in some real-world tasks, each training sample is associated with not only…

Machine Learning · Computer Science 2022-12-20 Wei Tang , Weijia Zhang , Min-Ling Zhang

Whole Slide Image (WSI) classification remains a challenge due to their extremely high resolution and the absence of fine-grained labels. Presently, WSI classification is usually regarded as a Multiple Instance Learning (MIL) problem when…

Computer Vision and Pattern Recognition · Computer Science 2023-08-24 Hongyi Wang , Luyang Luo , Fang Wang , Ruofeng Tong , Yen-Wei Chen , Hongjie Hu , Lanfen Lin , Hao Chen

In this work, we propose a simple model that provides permutation invariant maximally predictive prototype generator from a given dataset, which leads to interpretability of the solution and concrete insights to the nature and the solution…

Machine Learning · Computer Science 2021-01-25 Mert Yuksekgonul , Ozgur Emre Sivrikaya , Mustafa Gokce Baydogan