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In cryo-electron microscopy (EM), molecular structures are determined from large numbers of projection images of individual particles. To harness the full power of this single-molecule information, we use the Bayesian inference of EM…

Biomolecules · Quantitative Biology 2018-01-17 Pilar Cossio , David Rohr , Fabio Baruffa , Markus Rampp , Volker Lindenstruth , Gerhard Hummer

Cryo-Electron Microscopy (cryo-EM) has become an extremely powerful method for resolving structural details of large biomolecular complexes. However, challenging problems in single-particle methods remain open because of (1) the low…

Biomolecules · Quantitative Biology 2019-08-12 Shengnan Lyu , Christian Wülker , Yuqing Pan , Amitesh S. Jayaraman , Jianhao Zheng , Yilin Cai , Gregory S. Chirikjian

Single-particle electron cryomicroscopy (cryo-EM) is an increasingly popular technique for elucidating the three-dimensional structure of proteins and other biologically significant complexes at near-atomic resolution. It is an imaging…

Computational Physics · Physics 2020-04-01 Amit Singer , Fred J. Sigworth

Controlling crystalline material defects is crucial, as they affect properties of the material that may be detrimental or beneficial for the final performance of a device. Defect analysis on the sub-nanometer scale is enabled by…

Materials Science · Physics 2021-06-03 Nik Dennler , Antonio Foncubierta-Rodriguez , Titus Neupert , Marilyne Sousa

Dual-comb microscopy (DCM), an interesting imaging modality based on the optical-frequency-comb (OFC) mode and image pixel one-to-one correspondence, benefits from scan-less full-field imaging and simultaneous confocal amplitude and phase…

The contrast transfer function (CTF) is widely used to evaluate phase retrieval methods in scanning transmission electron microscopy (STEM), including center-of-mass imaging, parallax imaging, direct ptychography, and iterative…

Weak measurement (WM) with state pre- and post-selection can amplify otherwise undetectable small signals and thus promise great potentials in precision measurements. Although frequency measurements offer the hitherto highest precision…

Atomic Physics · Physics 2018-12-10 Weizhi Qu , Jian Sun , Shenchao Jin , Liang Jiang , Jianming Wen , Yanhong Xiao

The three-dimensional structure of proteins plays a crucial role in determining their function. Protein structure prediction methods, like AlphaFold, offer rapid access to a protein structure. However, large protein complexes cannot be…

Biomolecules · Quantitative Biology 2025-03-05 Gabriel Ducrocq , Lukas Grunewald , Sebastian Westenhoff , Fredrik Lindsten

A practical method utilising three-dimensional image pattern matching is proposed which, in principle, is capable of unambiguous determination of the types and positions of atoms in small molecules from defocus series collected at only a…

Image and Video Processing · Electrical Eng. & Systems 2019-12-02 T. E. Gureyev , H. M. Quiney , A. Kozlov , L. J. Allen

The recently developed information-theoretic approach to crystallographic symmetry classifications and quantifications in two dimensions (2D) from digital transmission electron and scanning probe microscope images is adapted for the…

Materials Science · Physics 2022-08-10 Peter Moeck , Lukas von Koch

Individual Head-Related Transfer Functions (HRTFs), crucial for realistic virtual audio rendering, can be efficiently numerically computed from precise three-dimensional head and ear scans. While photogrammetry scanning is promising, it…

Audio and Speech Processing · Electrical Eng. & Systems 2024-10-30 Fabio Di Giusto , Francesc Lluís , Sjoerd van Ophem , Elke Deckers

In this paper, we propose a novel structural correlation filter combined with a multi-task Gaussian particle filter (KCF-GPF) model for robust visual tracking. We first present an assemble structure where several KCF trackers as weak…

Computer Vision and Pattern Recognition · Computer Science 2018-03-18 Manna Dai , Shuying Cheng , Xiangjian He , Dadong Wang

In this work, image analysis techniques used in astrophysics to detect low-contrast signals have been adapted in the processing of Computed Tomography (CT) images, combining Centroidal Voronoi Tessellation (CVT) and machine learning…

Medical Physics · Physics 2025-03-11 Lorenzo Lasagni

A novel method performing 3D PTV from double frame multi-camera images is introduced. Particle velocities are estimated by following three steps. Firstly, separate particle reconstructions with a sparsity-based algorithm are performed on a…

Artificial intelligence-based methods have generated substantial interest in nuclear medicine. An area of significant interest has been using deep-learning (DL)-based approaches for denoising images acquired with lower doses, shorter…

Image and Video Processing · Electrical Eng. & Systems 2023-04-04 Zitong Yu , Md Ashequr Rahman , Richard Laforest , Thomas H. Schindler , Robert J. Gropler , Richard L. Wahl , Barry A. Siegel , Abhinav K. Jha

An outstanding question in X-ray single particle imaging experiments has been the feasibility of imaging sub 10-nm-sized biomolecules under realistic experimental conditions where very few photons are expected to be measured in a single…

Passive millimeter-wave (PMMW) is a significant potential technique for human security screening. Several popular object detection networks have been used for PMMW images. However, restricted by the low resolution and high noise of PMMW…

Computer Vision and Pattern Recognition · Computer Science 2023-07-10 Cheng Guo , Fei Hu , Yan Hu

The transformer based model (e.g., FusingTF) has been employed recently for Electrocardiogram (ECG) signal classification. However, the high-dimensional embedding obtained via 1-D convolution and positional encoding can lead to the loss of…

Signal Processing · Electrical Eng. & Systems 2021-04-01 Jian Guan , Wenbo Wang , Pengming Feng , Xinxin Wang , Wenwu Wang

Dislocations control the mechanical behavior of crystalline materials, yet their quantitative characterization in bulk has remained elusive. Transmission Electron Microscopy provides atomic-scale resolution but is restricted to thin foils,…

Materials Science · Physics 2026-03-05 A. Benhadjira , C. Detlefs , S. Borgi , V. Favre-Nicolin , C. Yildirim

This publication presents an investigation of the performance of different analytical electron ptychography methods for low-dose imaging. In particular, benchmarking is performed for two model-objects, monolayer MoS$_2$ and apoferritin, by…

Applied Physics · Physics 2025-05-20 Hoelen L. Lalandec Robert , Max Leo Leidl , Knut Müller-Caspary , Jo Verbeeck
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