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Direct detector device (DDD) cameras have revolutionized single particle electron cryomicroscopy (cryo-EM). In addition to an improved camera detective quantum efficiency, acquisition of DDD movies allows for correction of movement of the…

Quantitative Methods · Quantitative Biology 2015-11-23 John L. Rubinstein , Marcus A. Brubaker

Material properties strongly depend on the nature and concentration of defects. Characterizing these features may require nano- to atomic-scale resolution to establish structure-property relationships. 4D-STEM, a technique where diffraction…

Materials Science · Physics 2023-05-03 Stephanie M. Ribet , Colin Ophus , Roberto dos Reis , Vinayak P. Dravid

Classification is one of the core problems in Computer-Aided Diagnosis (CAD), targeting for early cancer detection using 3D medical imaging interpretation. High detection sensitivity with desirably low false positive (FP) rate is critical…

Computer Vision and Pattern Recognition · Computer Science 2014-05-20 Meizhu Liu , Le Lu , Xiaojing Ye , Shipeng Yu

Single-particle cryo-electron microscopy (cryo-EM) has become a cornerstone of structural biology, enabling near-atomic resolution analysis of macromolecules through advanced computational methods. However, the development of cryo-EM…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Runmin Jiang , Genpei Zhang , Yuntian Yang , Siqi Wu , Minhao Wu , Wanyue Feng , Yizhou Zhao , Xi Xiao , Xiao Wang , Tianyang Wang , Xingjian Li , Muyuan Chen , Min Xu

The search for low-mass dark matter (DM) goes in parallel with the identification of new detection channels and the development of suitable detectors. Detection of the resulting small energy depositions is challenging: it requires extremely…

Materials Science · Physics 2023-11-21 Martí Raya-Moreno , Bradley J. Kavanagh , Lourdes Fàbrega , Riccardo Rurali

Single-particle cryo-electron microscopy (cryo-EM) is a leading technology to resolve the structure of molecules. Early in the process, the user detects potential particle images in the raw data. Typically, there are many false detections…

Image and Video Processing · Electrical Eng. & Systems 2023-03-08 Gili Weiss-Dicker , Amitay Eldar , Yoel Shkolinsky , Tamir Bendory

Cryo-electron tomography (cryo-ET) is an imaging technique that allows three-dimensional visualization of macro-molecular assemblies under near-native conditions. Cryo-ET comes with a number of challenges, mainly low signal-to-noise and…

Scalable atom-based quantum platforms for simulation, computing, and metrology require fast high-fidelity, low-loss imaging of individual atoms. Standard fluorescence detection methods rely on continuous cooling, limiting the detection…

The use of Environmental Microorganisms (EMs) offers a highly efficient, low cost and harmless remedy to environmental pollution, by monitoring and decomposing of pollutants. This relies on how the EMs are correctly segmented and…

Computer Vision and Pattern Recognition · Computer Science 2022-09-01 Frank Kulwa , Chen Li , Marcin Grzegorzek , Md Mamunur Rahaman , Kimiaki Shirahama , Sergey Kosov

High-angle annular dark-field scanning transmission electron microscopy (HAADF-STEM) is a vital tool for characterizing single-atom catalysts (SACs). However, reliable elemental identification of different atoms remains challenging because…

Materials Science · Physics 2025-05-09 Yangfan Li , Yue Pan , Xincheng Lei , Weiwei Chen , Yang Shen , Mengshu Ge , Xiaozhi Liu , Dong Su

We experimentally demonstrate a detection scheme suitable for state analysis of single optically trapped atoms in less than 1 {\mu}s with an overall detection efficiency {\eta} exceeding 98%. The method is based on hyperfine-state-selective…

Cryo-electron microscopy (cryo-EM) is capable of producing reconstructed 3D images of biomolecules at near-atomic resolution. As such, it represents one of the most promising imaging techniques in structural biology. However, raw cryo-EM…

Quantitative Methods · Quantitative Biology 2021-05-25 Nina Miolane , Frédéric Poitevin , Yee-Ting Li , Susan Holmes

Multi-pass transmission electron microscopy (MPTEM) has been proposed as a way to reduce damage to radiation-sensitive materials. For the field of cryo-electron microscopy (cryo-EM), this would significantly reduce the number of projections…

A single-particle cryo-electron microscopy (cryo-EM) measurement, called a micrograph, consists of multiple two-dimensional tomographic projections of a three-dimensional (3-D) molecular structure at unknown locations, taken under unknown…

Image and Video Processing · Electrical Eng. & Systems 2026-03-10 Shay Kreymer , Amit Singer , Tamir Bendory

Dual-energy computed tomography (DECT) has shown great potential and promising applications in advanced imaging fields for its capabilities of material decomposition. However, image reconstructions and decompositions under sparse views…

Medical Physics · Physics 2016-08-01 Lei Li , Ailong Cai , Linyuan Wang , Bin Yan , Hanming Zhang , Zhizhong Zheng , Wenkun Zhang , Wanli Lu , Guoen Hu

We identify a number of crystalline structures with promising characteristics to serve as a detection medium for a novel Dark Matter (DM) detector with a low threshold energy. A detector of this kind can be specifically useful in…

Long Time Coherent Integration (LTCI) aims to accumulate target energy through long time integration, which is an effective method for the detection of a weak target. However, for a moving target, defocusing can occur due to range migration…

Systems and Control · Electrical Eng. & Systems 2024-03-12 Suqi Li , Yihan Wang , Bailu Wang , Giorgio Battistelli , Luigi Chisci , Guolong Cui

In this paper, a dual estimation methodology is developed for both time-varying parameters and states of a nonlinear stochastic system based on the Particle Filtering (PF) scheme. Our developed methodology is based on a concurrent…

Systems and Control · Computer Science 2016-06-29 Najmeh Daroogheh , Nader Meskin , Khashayar Khorasani

Temporal Forgery Localization (TFL) aims to precisely identify manipulated segments within videos or audio streams, providing interpretable evidence for multimedia forensics and security. While most existing TFL methods rely on dense…

Computer Vision and Pattern Recognition · Computer Science 2026-03-06 Xiaodong Zhu , Yuanming Zheng , Suting Wang , Junqi Yang , Yuhong Yang , Weiping Tu , Zhongyuan Wang

Three-dimensional electron diffraction (3D ED) has emerged as a powerful method for solving the structures of sub-micron-sized particles down to nanoparticles. However, it faces technical challenges when applied to beam-sensitive samples or…