English
Related papers

Related papers: Transcriptional delay stabilizes bistable gene net…

200 papers

This paper considers $L_2$ and BIBO stability and stabilization issues for systems with time-varying delays which can be of retarded or neutral type. An important role is played by a nominal system with fixed delays which are close to the…

Dynamical Systems · Mathematics 2020-03-16 Catherine Bonnet , Jonathan R. Partington

Time delays pose an important challenge in networked control systems, which are now ubiquitous. Focusing on switched systems, we introduce a framework that provides an upper bound for errors caused by switching delays. Our framework is…

Systems and Control · Computer Science 2017-12-27 Kengo Kido , Sean Sedwards , Ichiro Hasuo

In this paper, we exploit a diagonally dominant structure for the decentralized stabilization of unknown nonlinear time-delayed networks. To this end, we first introduce a novel generalization of virtual contraction analysis to diagonally…

Systems and Control · Electrical Eng. & Systems 2025-09-23 Yu Kawano , Zhiyong Sun

Gene expression is controlled primarily by interactions between transcription factor proteins (TFs) and the regulatory DNA sequence, a process that can be captured well by thermodynamic models of regulation. These models, however, neglect…

Molecular Networks · Quantitative Biology 2015-12-16 Sarah A Cepeda-Humerez , Georg Rieckh , Gašper Tkačik

To generate coherent responses, language models infer unobserved meaning from their input text sequence. One potential explanation for this capability arises from theories of delay embeddings in dynamical systems, which prove that…

Machine Learning · Computer Science 2024-06-19 Mitchell Ostrow , Adam Eisen , Ila Fiete

A one species time-delay reaction-diffusion system defined on a complex networks is studied. Travelling waves are predicted to occur as follows a symmetry breaking instability of an homogenous stationary stable solution, subject to an…

Statistical Mechanics · Physics 2015-09-30 Julien Petit , Timoteo Carletti , Mabor Asslani , Duccio Fanelli

Some features of random networks with excitable nodes that are embeddable in the Euclidean space are not describable in terms of the conventional integrate and fire model (IFM) alone, and some further details should be involved. In the…

Statistical Mechanics · Physics 2019-03-27 M. N. Najafi , M. Rahimi

Objective: The reservoir of human immunodeficiency virus (HIV) latently infected cells is the major obstacle for eradication of acquired immunodeficiency syndrome (AIDS). Due to the noisy environment and multiple influencing factors in the…

Biological Physics · Physics 2024-11-06 Ruiqi Xiong , Yang Su , Ping Ao

We study the nonlinear dynamics of two delay-coupled neural systems each modelled by excitable dynamics of FitzHugh-Nagumo type and demonstrate that bistability between the stable fixed point and limit cycle oscillations occurs for…

Pattern Formation and Solitons · Physics 2015-05-13 M. A. Dahlem , G. Hiller , A. Panchuk , E. Schoell

Genes with similar transcriptional activation kinetics can display very different temporal mRNA profiles due to differences in transcription time, degradation rate and RNA processing kinetics. Recent studies have shown that a…

In this paper, we consider the stability analysis of large-scale distributed networked control systems with random communication delays between linearly interconnected subsystems. The stability analysis is performed in the Markov jump…

Systems and Control · Computer Science 2015-11-13 Kooktae Lee , Raktim Bhattacharya

New methods are developed for the stabilization of a linear system with general time-varying distributed delays existing at the system's states, inputs and outputs. In contrast to most existing literature where the function of time-varying…

Systems and Control · Electrical Eng. & Systems 2024-12-20 Qian Feng , Sing Kiong Nguang , Wilfrid Perruquetti

We study a mathematical model describing the dynamics of a pluripotent stem cell population involved in the blood production process in the bone marrow. This model is a differential equation with a time delay. The delay describes the cell…

Analysis of PDEs · Mathematics 2009-04-17 Mostafa Adimy , Fabien Crauste , Shigui Ruan

Understanding how time delays impact the stability of a delay differential equation is important for modeling many natural and technological systems that experience time delays. Here we introduce a new stability criterion for…

Dynamical Systems · Mathematics 2025-08-25 Quinlan Leishman , Benjamin Webb

Cells and tissues exhibit oscillatory deformations during remodelling, migration or embryogenesis. Although it has been shown that these oscillations correlate with cell biochemical signalling, it is yet unclear the role of these…

Tissues and Organs · Quantitative Biology 2021-01-20 Malik A Dawi , Jose J Munoz

The plasticity of the conduction delay between neurons plays a fundamental role in learning. However, the exact underlying mechanisms in the brain for this modulation is still an open problem. Understanding the precise adjustment of…

Neural and Evolutionary Computing · Computer Science 2020-11-19 Alireza Nadafian , Mohammad Ganjtabesh

This paper focuses on time-varying delayed stochastic differential systems with stochastically switching parameters formulated by a unified switching behavior combining a discrete adapted process and a Cox process. Unlike prior studies…

Dynamical Systems · Mathematics 2024-01-30 Xinyu Wu , Zidong Wang , Wenlian Lu

Much recent progress has been achieved for stabilization of linear and nonlinear systems with input delays that are long and dependent on either time or the plant state---provided the dependence is known. In this paper we consider the delay…

Optimization and Control · Mathematics 2012-09-11 Nikolaos Bekiaris-Liberis , Miroslav Krstic

Flexible modulation of temporal dynamics in neural sequences underlies many cognitive processes. For instance, we can adaptively change the speed of motor sequences and speech. While such flexibility is influenced by various factors such as…

Neurons and Cognition · Quantitative Biology 2025-04-15 Tomoki Kurikawa , Kunihiko Kaneko

Specific activator and repressor transcription factors which bind to specific regulator DNA sequences, play an important role in gene activity control. Interactions between genes coding such transcription factors should explain the…

Dynamical Systems · Mathematics 2015-06-26 Gh. I. Mihalas , M. Neamtu , D. Opris , F. Horhat