English
Related papers

Related papers: Transcriptional delay stabilizes bistable gene net…

200 papers

We study systems of identical coupled oscillators introducing a distribution of delay times in the coupling. For arbitrary network topologies, we show that the frequency and stability of the fully synchronized states depend only on the mean…

Chaotic Dynamics · Physics 2016-07-04 Lucas Wetzel , Luis G. Morelli , Andrew C. Oates , Frank Julicher , Saul Ares

We demonstrate the effects of embedding subgraphs using a Boolean network, which is one of the discrete dynamical models for transcriptional regulatory networks. After comparing the dynamical properties of network embedded seven different…

Cellular Automata and Lattice Gases · Physics 2008-06-26 Chikoo Oosawa , Michael A. Savageau , Abdul S. Jarrah , Reinhard C. Laubenbacher , Eduardo D. Sontag

Driven by the explosion of data and the impact of real-world networks, a wide array of mathematical models have been proposed to understand the structure and evolution of such systems, especially in the temporal context. Recent advances in…

Probability · Mathematics 2024-09-11 Sayan Banerjee , Shankar Bhamidi , Partha Dey , Akshay Sakanaveeti

We present three examples of delayed bifurcations for spike solutions of reaction-diffusion systems. The delay effect results as the system passes slowly from a stable to an unstable regime, and was previously analysed in the context of…

Pattern Formation and Solitons · Physics 2015-06-18 Justin C. Tzou , Michael J. Ward , Theodore Kolokolnikov

This work mainly investigates the mean-square stability and stabilizability for a single-input single-output networked linear feedback system. The control signal in the networked system is transmitted over an unreliable channel. In this…

Systems and Control · Electrical Eng. & Systems 2021-08-31 Weizhou Su , Junhui Li , Jieying Lu

We demonstrate the advantages of feedforward loops using a Boolean network, which is one of the discrete dynamical models for transcriptional regulatory networks. After comparing the dynamical behaviors of network embedded feedback and…

Cellular Automata and Lattice Gases · Physics 2008-02-14 Chikoo Oosawa , Kazuhiro Takemoto , Michael A. Savageau

Network science has become an essential interdisciplinary tool for understanding complex biological systems. However, because these systems undergo continuous, often stimulus-driven changes in both structure and function, traditional static…

Molecular Networks · Quantitative Biology 2025-05-19 Abir Khazaal , Fatemeh Vafaee

Train delays are a persistent issue in railway systems, particularly in suburban networks where operational complexity is heightened by frequent services and high passenger volumes. Traditional delay models often overlook the temporal and…

Applications · Statistics 2025-12-08 Stefania Colombo , Alfredo Gimenez Zapiola , Francesca Ieva , Simone Vantini

The elapsed-time model describes the behavior of interconnected neurons through the time since their last spike. It is an age-structured non-linear equation in which age corresponds to the elapsed time since the last discharge, and models…

Dynamical Systems · Mathematics 2025-04-28 María J. Cáceres , José A Cañizo , Nicolas Torres

Recent studies have shown that retransmissions can cause heavy-tailed transmission delays even when packet sizes are light-tailed. Moreover, the impact of heavy-tailed delays persists even when packets size are upper bounded. The key…

Information Theory · Computer Science 2012-02-22 Yang Yang , Jian Tan , Ness B. Shroff , Hesham El-Gamal

In a stochastic process, noise often modifies the picture offered by the mean field dynamics. In particular, when there is an absorbing state, the noise erases a stable fixed point of the mean field equation from the stationary…

Statistical Mechanics · Physics 2018-12-19 JaeJun Lee , Julian Lee

We present an analysis of time-delayed feedback control used to stabilize an unstable steady state of a neutral delay differential equation. Stability of the controlled system is addressed by studying the eigenvalue spectrum of a…

Chaotic Dynamics · Physics 2012-09-21 K. B. Blyuss , Y. N. Kyrychko , P. Hoevel , E. Schoell

We investigate the stability of synchronization in networks of delay-coupled excitable neural oscillators. On the basis of the master stability function formalism, we demonstrate that synchronization is always stable for excitatory coupling…

Disordered Systems and Neural Networks · Physics 2016-08-10 Judith Lehnert , Thomas Dahms , Philipp Hövel , Eckehard Schöll

We study the effects of nonzero time delays in stochastic synchronization problems with linear couplings in complex networks. We consider two types of time delays: transmission delays between interacting nodes and local delays at each node…

Statistical Mechanics · Physics 2012-12-03 D. Hunt , B. K. Szymanski , G. Korniss

We study the possibility to stabilize unstable steady states and unstable periodic orbits in chaotic fractional-order dynamical systems by the time-delayed feedback method. By performing a linear stability analysis, we establish the…

General Physics · Physics 2011-07-07 Aleksandar Gjurchinovski , Trifce Sandev , Viktor Urumov

Complex systems are often modeled as Boolean networks in attempts to capture their logical structure and reveal its dynamical consequences. Approximating the dynamics of continuous variables by discrete values and Boolean logic gates may,…

Molecular Networks · Quantitative Biology 2013-05-29 Johannes Norrell , Joshua E. S. Socolar

Quasi steady state assumptions are often used to simplify complex systems of ordinary differential equations in modelling of biochemical processes. The simplified system is designed to have the same qualitative properties as the original…

Dynamical Systems · Mathematics 2013-12-11 Tomáš Vejchodský

We find that discrete noise of inhibiting (signal) molecules can greatly delay the extinction of plasmids in a plasmid replication system: a prototypical biochemical regulatory network. We calculate the probability distribution of the…

Molecular Networks · Quantitative Biology 2016-10-06 Michael Assaf , Baruch Meerson

Neurons in many brain areas can develop pronounced depolarized state of membrane potential (up state) in addition to the normal hyperpolarized down state near the resting potential. The influence of the up state on signal encoding, however,…

Neurons and Cognition · Quantitative Biology 2015-09-30 Wei Wei , Fred Wolf , Xiao-Jing Wang

Gene regulatory dynamics is governed by molecular processes and therefore exhibits an inherent stochasticity. However, for the survival of an organism it is a strict necessity that this intrinsic noise does not prevent robust functioning of…

Molecular Networks · Quantitative Biology 2007-05-23 Stefan Braunewell , Stefan Bornholdt