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In the case of malware analysis, categorization of malicious files is an essential part after malware detection. Numerous static and dynamic techniques have been reported so far for categorizing malware. This research presents a deep…

Cryptography and Security · Computer Science 2020-12-29 Muhammad Furqan Rafique , Muhammad Ali , Aqsa Saeed Qureshi , Asifullah Khan , Anwar Majid Mirza

Biological foundation models (BioFMs), pretrained on large-scale biological sequences, have recently shown strong potential in providing meaningful representations for diverse downstream bioinformatics tasks. However, such models often rely…

Machine Learning · Computer Science 2026-02-10 Yifan Wu , Jiyue Jiang , Xichen Ye , Yiqi Wang , Chang Zhou , Yitao Xu , Jiayang Chen , He Hu , Weizhong Zhang , Cheng Jin , Jiao Yuan , Yu Li

The use of machine learning and intelligent systems has become an established practice in the realm of malware detection and cyber threat prevention. In an environment characterized by widespread accessibility and big data, the feasibility…

Machine Learning · Computer Science 2019-07-09 Sean M. Devine , Nathaniel D. Bastian

Prediction of protein secondary structure from the amino acid sequence is a classical bioinformatics problem. Common methods use feed forward neural networks or SVMs combined with a sliding window, as these models does not naturally handle…

Quantitative Methods · Quantitative Biology 2015-01-06 Søren Kaae Sønderby , Ole Winther

Deep learning (DL) techniques have shown unprecedented success when applied to images, waveforms, and text. Generally, when the sample size ($N$) is much bigger than the number of features ($d$), DL often outperforms other machine learning…

Computer Vision and Pattern Recognition · Computer Science 2018-06-26 Thanh Hai Nguyen , Edi Prifti , Yann Chevaleyre , Nataliya Sokolovska , Jean-Daniel Zucker

Machine learning models are commonly used for malware classification; however, they suffer from performance degradation over time due to concept drift. Adapting these models to changing data distributions requires frequent updates, which…

Machine Learning · Computer Science 2025-08-05 Md Tanvirul Alam , Aritran Piplai , Nidhi Rastogi

Similarity metrics, e.g., signatures as used by anti-virus products, are the dominant technique to detect if a given binary is malware. The underlying assumption of this approach is that all instances of a malware (or even malware family)…

Cryptography and Security · Computer Science 2014-09-30 Mathias Payer , Stephen Crane , Per Larsen , Stefan Brunthaler , Richard Wartell , Michael Franz

This paper assesses the performance of five machine learning classifiers: Decision Tree, Naive Bayes, LightGBM, Logistic Regression, and Random Forest using latent representations learned by a Variational Autoencoder from malware datasets.…

Cryptography and Security · Computer Science 2025-05-01 Bamidele Ajayi , Basel Barakat , Ken McGarry

miRNA and gene expression profiles have been proved useful for classifying cancer samples. Efficient classifiers have been recently sought and developed. A number of attempts to classify cancer samples using miRNA/gene expression profiles…

Computational Engineering, Finance, and Science · Computer Science 2014-01-21 Rania Ibrahim , Noha A. Yousri , Mohamed A. Ismail , Nagwa M. El-Makky

The threat of malware is a serious concern for computer networks and systems, highlighting the need for accurate classification techniques. In this research, we experiment with multimodal machine learning approaches for malware…

Cryptography and Security · Computer Science 2025-01-22 Jonathan Jiang , Mark Stamp

Protein-protein bindings play a key role in a variety of fundamental biological processes, and thus predicting the effects of amino acid mutations on protein-protein binding is crucial. To tackle the scarcity of annotated mutation data,…

Quantitative Methods · Quantitative Biology 2024-05-20 Lirong Wu , Yijun Tian , Haitao Lin , Yufei Huang , Siyuan Li , Nitesh V Chawla , Stan Z. Li

Recent advances in high-throughput genomic technologies coupled with exponential increases in computer processing and memory have allowed us to interrogate the complex aberrant molecular underpinnings of human disease from a genome-wide…

Inferring topological and geometrical information from data can offer an alternative perspective on machine learning problems. Methods from topological data analysis, e.g., persistent homology, enable us to obtain such information,…

Computer Vision and Pattern Recognition · Computer Science 2018-02-19 Christoph Hofer , Roland Kwitt , Marc Niethammer , Andreas Uhl

The integration of machine learning methods into bioinformatics provides particular benefits in identifying how therapeutics effective in one context might have utility in an unknown clinical context or against a novel pathology. We aim to…

Machine Learning · Computer Science 2020-06-29 Semih Cantürk , Aman Singh , Patrick St-Amant , Jason Behrmann

Nowadays, the amount of heterogeneous biomedical data is increasing more and more thanks to novel sensing techniques and high-throughput technologies. In reference to biomedical image analysis, the advances in image acquisition modalities…

Image and Video Processing · Electrical Eng. & Systems 2021-06-09 Leonardo Rundo

Malware evolves over time and antivirus must adapt to such evolution. Hence, it is critical to detect those points in time where malware has evolved so that appropriate countermeasures can be undertaken. In this research, we perform a…

Cryptography and Security · Computer Science 2021-07-06 Lolitha Sresta Tupadha , Mark Stamp

In today's digital world most of the anti-malware tools are signature based which is ineffective to detect advanced unknown malware viz. metamorphic malware. In this paper, we study the frequency of opcode occurrence to detect unknown…

Cryptography and Security · Computer Science 2019-03-08 Sanjay Sharma , C. Rama Krishna , Sanjay K. Sahay

Memory forensics is an effective methodology for analyzing living-off-the-land malware, including threats that employ evasion, obfuscation, anti-analysis, and steganographic techniques. By capturing volatile system state, memory analysis…

Cryptography and Security · Computer Science 2026-02-24 Silvia Lucia Sanna , Davide Maiorca , Giorgio Giacinto

Malicious software (malware) classification offers a unique challenge for continual learning (CL) regimes due to the volume of new samples received on a daily basis and the evolution of malware to exploit new vulnerabilities. On a typical…

Cryptography and Security · Computer Science 2022-08-16 Mohammad Saidur Rahman , Scott E. Coull , Matthew Wright

Motivated by the transformative impact of deep neural networks (DNNs) in various domains, researchers and anti-virus vendors have proposed DNNs for malware detection from raw bytes that do not require manual feature engineering. In this…

Cryptography and Security · Computer Science 2021-10-26 Keane Lucas , Mahmood Sharif , Lujo Bauer , Michael K. Reiter , Saurabh Shintre