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Applying machine learning to biological sequences - DNA, RNA and protein - has enormous potential to advance human health, environmental sustainability, and fundamental biological understanding. However, many existing machine learning…

Machine Learning · Statistics 2023-04-11 Alan Nawzad Amin , Eli Nathan Weinstein , Debora Susan Marks

In a context of malicious software detection, machine learning (ML) is widely used to generalize to new malware. However, it has been demonstrated that ML models can be fooled or may have generalization problems on malware that has never…

Cryptography and Security · Computer Science 2023-06-08 Grégoire Barrué , Tony Quertier

For efficient malware removal, determination of malware threat levels, and damage estimation, malware family classification plays a critical role. In this paper, we extract features from malware executable files and represent them as images…

Cryptography and Security · Computer Science 2022-07-04 Huy Nguyen , Fabio Di Troia , Genya Ishigaki , Mark Stamp

A novel approach to malware classification is introduced based on analysis of instruction traces that are collected dynamically from the program in question. The method has been implemented online in a sandbox environment (i.e., a security…

Applications · Statistics 2014-04-10 Curtis Storlie , Blake Anderson , Scott Vander Wiel , Daniel Quist , Curtis Hash , Nathan Brown

This work addresses classification of unknown binaries executed in sandbox by modeling their interaction with system resources (files, mutexes, registry keys and communication with servers over the network) and error messages provided by…

Cryptography and Security · Computer Science 2017-05-08 Jan Stiborek , Tomáš Pevný , Martin Rehák

With the rapid growth of the number of devices on the Internet, malware poses a threat not only to the affected devices but also their ability to use said devices to launch attacks on the Internet ecosystem. Rapid malware classification is…

Cryptography and Security · Computer Science 2021-07-30 Hikmat Farhat , Veronica Rammouz

Malware authors are continuously evolving their code base to include counter-analysis methods that can significantly hinder their detection and blocking. While the execution of malware in a sandboxed environment may provide a lot of…

Cryptography and Security · Computer Science 2022-04-11 Vasilis Vouvoutsis , Fran Casino , Constantinos Patsakis

Personalized head and neck cancer therapeutics have greatly improved survival rates for patients, but are often leading to understudied long-lasting symptoms which affect quality of life. Sequential rule mining (SRM) is a promising…

Human-Computer Interaction · Computer Science 2023-09-28 Carla Floricel , Andrew Wentzel , Abdallah Mohamed , C. David Fuller , Guadalupe Canahuate , G. Elisabeta Marai

Training pipelines for machine learning (ML) based malware classification often rely on crowdsourced threat feeds, exposing a natural attack injection point. In this paper, we study the susceptibility of feature-based ML malware classifiers…

Cryptography and Security · Computer Science 2021-01-12 Giorgio Severi , Jim Meyer , Scott Coull , Alina Oprea

The majority of mammalian genomic transcripts do not directly code for proteins and it is currently believed that most of these are not under evolutionary constraint. However given the abundance non-coding RNA (ncRNA) and its strong…

Molecular Networks · Quantitative Biology 2016-08-22 J. M. Deutsch

The recent development of metagenomic sequencing makes it possible to sequence microbial genomes including viruses in an environmental sample. Identifying viral sequences from metagenomic data is critical for downstream virus analyses. The…

Genomics · Quantitative Biology 2018-06-21 Jie Ren , Kai Song , Chao Deng , Nathan A. Ahlgren , Jed A. Fuhrman , Yi Li , Xiaohui Xie , Fengzhu Sun

MicroRNAs (miRNAs) are non-coding RNAs with approximately 22 nucleotides (nt) that are derived from precursor molecules. These precursor molecules or pre-miRNAs often fold into stem-loop hairpin structures. However, a large number of…

Genomics · Quantitative Biology 2016-10-10 Ling Zhong , Jason T. L. Wang

When investigating a malicious file, searching for related files is a common task that malware analysts must perform. Given that production malware corpora may contain over a billion files and consume petabytes of storage, many feature…

Cryptography and Security · Computer Science 2023-06-13 Robert J. Joyce , Tirth Patel , Charles Nicholas , Edward Raff

Malware, a persistent cybersecurity threat, increasingly targets interconnected digital systems such as desktop, mobile, and IoT platforms through sophisticated attack vectors. By exploiting these vulnerabilities, attackers compromise the…

Cryptography and Security · Computer Science 2025-10-09 Matteo Brosolo , Asmitha K. A. , Mauro Conti , Rafidha Rehiman K. A. , Muhammed Shafi K. P. , Serena Nicolazzo , Antonino Nocera , Vinod P

We propose a deep learning approach for identifying malware families using the function call graphs of x86 assembly instructions. Though prior work on static call graph analysis exists, very little involves the application of modern,…

Cryptography and Security · Computer Science 2020-12-04 Thomas Dalton , Mauritius Schmidtler , Alireza Hadj Khodabakhshi

As in many other scientific domains, we face a fundamental problem when using machine learning to identify proteins from mass spectrometry data: large ground truth datasets mapping inputs to correct outputs are extremely difficult to…

Bio-inspired algorithms utilize natural processes such as evolution, swarm behavior, foraging, and plant growth to solve complex, nonlinear, high-dimensional optimization problems. However, a plethora of these algorithms require a more…

Machine learning has been widely adopted for medical image analysis in recent years given its promising performance in image segmentation and classification tasks. As a data-driven science, the success of machine learning, in particular…

Computer Vision and Pattern Recognition · Computer Science 2020-07-06 Chengliang Dai , Shuo Wang , Yuanhan Mo , Kaichen Zhou , Elsa Angelini , Yike Guo , Wenjia Bai

Metamorphic viruses are considered the most dangerous of all computer viruses. Unlike other computer viruses that can be detected statically using static signature technique or dynamically using emulators, metamorphic viruses change their…

Cryptography and Security · Computer Science 2013-12-17 Moustafa Saleh

Numerous metamorphic and polymorphic malicious variants are generated automatically on a daily basis by mutation engines that transform the code of a malicious program while retaining its functionality, in order to evade signature-based…

Cryptography and Security · Computer Science 2021-06-28 Ron Korine , Danny Hendler