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Medically uncontrolled epileptic seizures affect nearly 15 million people worldwide, resulting in enormous economic and psychological burdens. Treatment of medically refractory epilepsy is essential for patients to achieve remission,…

Quantitative Methods · Quantitative Biology 2025-12-25 Yaoyue Wang , Arian Ashourvan , Guilherme Ramos , Paul Bogdan , Emily Pereira

Synchronization plays a fundamental role in healthy cognitive and motor function. However, how synchronization depends on the interplay between local dynamics, coupling and topology and how prone to synchronization a network with given…

Neurons and Cognition · Quantitative Biology 2018-06-06 David Papo , Javier M. Buldú

Epilepsy is a disorder characterised by spontaneous, recurrent seizures. Both local and network abnormalities have been associated with epilepsy, and the exact processes generating seizures are thought to be heterogeneous and…

Neurons and Cognition · Quantitative Biology 2019-01-07 Yujiang Wang , Gabrielle Marie Schroeder , Nishant Sinha , Peter Neal Taylor

The two-point central difference is a common algorithm in biological signal processing and is particularly useful in analyzing physiological signals. In this paper, we develop a model-based classification method to detect epileptic seizures…

Applications · Statistics 2020-06-01 Antonio Quintero-Rincon , Carlos D'Giano , Hadj Batatia

This paper presents an efficient binarized algorithm for both learning and classification of human epileptic seizures from intracranial electroencephalography (iEEG). The algorithm combines local binary patterns with brain-inspired…

Signal Processing · Electrical Eng. & Systems 2018-09-10 Alessio Burrello , Kaspar Schindler , Luca Benini , Abbas Rahimi

Synchronous oscillatory dynamics is frequently observed in the human brain. We analyze the fine temporal structure of phase-locking in a realistic network model and match it with the experimental data from parkinsonian patients. We show…

Neurons and Cognition · Quantitative Biology 2011-04-18 Choongseok Park , Robert M. Worth , Leonid L. Rubchinsky

Coherence analysis plays a vital role in the study of functional brain connectivity. However, coherence captures only linear spectral associations, and thus can produce misleading findings when ignoring variations of connectivity in the…

The onset of regular bursts in a group of irregularly bursting neurons with different individual properties is one of the most interesting dynamical properties found in neurobiological systems. In this paper we show how synchronization…

Chaotic Dynamics · Physics 2009-10-31 Nikolai F. Rulkov

The brain can be understood as a collection of interacting neuronal oscillators, but the extent to which its sustained activity is due to coupling among brain areas is still unclear. Here we study the joint dynamics of two cortical columns…

Neurons and Cognition · Quantitative Biology 2018-01-17 Maciej Jedynak , Antonio J. Pons , Jordi Garcia-Ojalvo

Epilepsy is a neurological disease characterized by recurrent and spontaneous seizures. It affects approximately 50 million people worldwide. In majority of the cases accurate diagnosis of the disease can be made without using any…

Quantitative Methods · Quantitative Biology 2013-04-05 Roxana A. Stephanescu , R. G. Shivakeshavan , Sachin S. Talathi

Electrical coupling between neurons is broadly present across brain areas and is typically assumed to synchronize network activity. However, intrinsic properties of the coupled cells can complicate this simple picture. Many cell types with…

Adaptation and Self-Organizing Systems · Physics 2018-01-19 Thomas Chartrand , Mark S. Goldman , Timothy J. Lewis

The prediction of epileptic seizure has always been extremely challenging in medical domain. However, as the development of computer technology, the application of machine learning introduced new ideas for seizure forecasting. Applying…

Machine Learning · Computer Science 2019-10-08 Haotian Liu , Lin Xi , Ying Zhao , Zhixiang Li

Epilepsy significantly impacts global health, affecting about 65 million people worldwide, along with various animal species. The diagnostic processes of epilepsy are often hindered by the transient and unpredictable nature of seizures.…

Signal Processing · Electrical Eng. & Systems 2026-04-21 Z. Wang , S. Li , Dongrui Wu

Electroencephalogram (EEG) is a prominent way to measure the brain activity for studying epilepsy, thereby helping in predicting seizures. Seizure prediction is an active research area with many deep learning based approaches dominating the…

Signal Processing · Electrical Eng. & Systems 2020-11-19 Zaid Bin Tariq , Arun Iyengar , Lara Marcuse , Hui Su , Bülent Yener

In a network of dynamical systems, concurrent synchronization is a regime where multiple groups of fully synchronized elements coexist. In the brain, concurrent synchronization may occur at several scales, with multiple ``rhythms''…

Neurons and Cognition · Quantitative Biology 2007-05-23 Quang-Cuong Pham , Jean-Jacques Slotine

Long-term monitoring of patients with epilepsy presents a challenging problem from the engineering perspective of real-time detection and wearable devices design. It requires new solutions that allow continuous unobstructed monitoring and…

Machine Learning · Computer Science 2022-04-11 Una Pale , Tomas Teijeiro , David Atienza

The dynamics of three mutually coupled cortical neurons with time delays in the coupling are explored numerically and analytically. The neurons are coupled in a line, with the middle neuron sending a somewhat stronger projection to the…

Chaotic Dynamics · Physics 2011-01-25 Alexandra S. Landsman , Ira B. Schwartz

We devised a measure based on the distributions of relative event timings of two coupled units. The measure dynamically evaluates temporal interdependencies between the two coupled units. Using this we show that even in the event of…

Chaotic Dynamics · Physics 2007-05-23 Michal Zochowski , Rhonda Dzakpasu

Identifying seizure activities in non-stationary electroencephalography (EEG) is a challenging task, since it is time-consuming, burdensome, and dependent on expensive human resources and subject to error and bias. A computerized seizure…

Signal Processing · Electrical Eng. & Systems 2020-04-29 S. Sheykhivand , T. Yousefi Rezaii , Z. Mousavi , A. Delpak , A. Farzamnia

Epilepsy is a chronic, noncommunicable brain disorder, and sudden seizure onsets can significantly impact patients' quality of life and health. However, wearable seizure-predicting devices are still limited, partly due to the bulky size of…

Signal Processing · Electrical Eng. & Systems 2025-07-22 Ruifeng Zheng , Cong Chen , Shuang Wang , Yiming Liu , Lin You , Jindong Lu , Ruizhe Zhu , Guodao Zhang , Kejie Huang