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We integrate a small and portable medical x-ray device with mechanical testing equipment to enable in-situ, non-invasive measurements of a granular material's response to mechanical loading. We employ an orthopedic C-arm as the x-ray source…

X-ray computed tomography is a powerful tool for volumetric imaging, where three-dimensional (3D) images are generated from a large number of individual X-ray projection images. Collecting the required number of low noise projection images…

Image and Video Processing · Electrical Eng. & Systems 2025-04-30 Zhenduo Shang , Thomas Blumensath

Interferometry provides one of the possible routes to ultra-high angular resolution for X-ray and gamma-ray astronomy. Sub-micro-arc-second angular resolution, necessary to achieve objectives such as imaging the regions around the event…

Instrumentation and Methods for Astrophysics · Physics 2009-07-31 G. K. Skinner , J. F. Krizmanic

Bright sources of high-energy X-rays and electrons are indispensable tools in advanced imaging. Yet, current laser-driven systems typically support only single-modality imaging, require complex infrastructure, or operate at low repetition…

Correlative microscopy is a powerful technique that combines the advantages of multiple imaging modalities to achieve a comprehensive understanding of investigated samples. For example, fluorescence microscopy provides unique functional…

We describe a full-field coherent imaging approach suitable for hard X-rays based on a classical (i.e. Galilean) X-ray microscope. The method combines a series of low-resolution images acquired at different transverse lens positions into a…

Optics · Physics 2019-05-07 Carsten Detlefs , Mario A. Beltran , Jean-Pierre Guigay , Hugh Simons

The nature of ultraluminous X-ray sources (ULXs) is not yet fully understood but it can be done in the most efficient way by analyzing its optical emission and environment. We present preliminary results of photometric and spectral studies…

High Energy Astrophysical Phenomena · Physics 2021-02-03 A. Vinokurov , K. Atapin , Y. Solovyeva , A. Sarkisyan , D. Oparin

Scanning transmission X-ray microscopy and ptychography have become mature tools for high-resolution, element-specific imaging of nanoscale structures. However, transmission geometries impose stringent constraints on sample thickness and…

Compact laboratory-scale X-ray sources still rely on the same fundamental principles as in the first X-ray tubes developed more than a century ago. In recent years, significant research and development have focused on large-scale X-ray…

While high-resolution microscopic techniques are crucial for studying cellular structures in cell biology, obtaining such images from thick 3D engineered tissues remains challenging. In this review, we explore advancements in fluorescence…

Tissues and Organs · Quantitative Biology 2025-02-07 Yasaman Kargar Gaz Kooh , Nathaniel Huebsch

X-ray tomography is a powerful volumetric imaging technique, but detailed three dimensional (3D) imaging requires the acquisition of a large number of individual X-ray images, which is time consuming. For applications where spatial…

Image and Video Processing · Electrical Eng. & Systems 2023-02-28 Zhenduo Shang , Thomas Blumensath

3D-localization of gamma sources has the potential to improve the outcome of radio-guided surgery. The goal of this paper is to analyze the localization accuracy for point-like sources with a single coded aperture camera. We both simulated…

Medical Physics · Physics 2024-06-24 Tobias Meißner , Laura Antonia Cerbone , Paolo Russo , Werner Nahm , Jürgen Hesser

By means of numerical simulations, we demonstrate the innovative use of computational ghost imaging in transmission electron microscopy to retrieve images with a resolution that overcomes the limitations imposed by coherent aberrations. The…

Instrumentation and Detectors · Physics 2024-11-20 P. Rosi , L. Viani , E. Rotunno , S. Frabboni , A. H. Tavabi , R. E. Dunin-Borkowski , A. Roncaglia , V. Grillo

The problem of optimization of propagation-based phase-contrast imaging setups is considered in the case of projection X-ray imaging and three-dimensional tomography with phase retrieval. For two-dimensional imaging, a simple model for a…

Medical Physics · Physics 2026-03-03 T. E. Gureyev , D. M. Paganin , H. M. Quiney

We model the absorption of X-rays by gas obscuring the source and photoionized by it. We consider a broad range of column densities, including both Thomson-thin and Thomson-thick media. For the Thomson thin regime, we derive a simple…

High Energy Astrophysical Phenomena · Physics 2026-04-08 Taya Govreen-Segal , Ehud Nakar , Eliot Quataert

In a comprehensive study on several samples we demonstrate for our laboratory-based computed tomography system resolutions down to 150nm. The achieved resolution is validated by imaging com-mon test structures in 2D and Fourier Shell…

Instrumentation and Detectors · Physics 2021-02-15 Dominik Müller , Jonas Graetz , Andreas Balles , Simon Stier , Randolf Hanke , Christian Fella

Due to the low X-ray photon utilization efficiency and low measurement sensitivity of the electron multiplying charge coupled device (EMCCD) camera setup, the collimator based narrow beam X-ray luminescence computed tomography (XLCT)…

Medical Physics · Physics 2018-03-14 Wei Zhang , Michael C Lun , Alex Anh-Tu Nguyen , Changqing Li

Astronomical imaging with micro-arcsecond ($\mu$as) angular resolution could enable breakthrough scientific discoveries. Previously-proposed $\mu$as X-ray imager designs have been interferometers with limited effective collecting area. Here…

Instrumentation and Methods for Astrophysics · Physics 2020-06-24 Brandon D. Chalifoux , Ralf K. Heilmann , Herman L. Marshall , Mark L. Schattenburg

Improvements in X-ray optics critically depend on the measurement of their optical performance. The knowledge of wavefront aberrations, for example, can be used to improve the fabrication of optical elements or to design phase correctors to…

Imaging specimens over large scales and with a sub-micron resolution is instrumental to biomedical research. Yet, the number of pixels to form such an image usually exceeds the number of pixels provided by conventional cameras. While most…

Instrumentation and Detectors · Physics 2019-12-03 Gaelle Recher , Pierre Nassoy , Amaury Badon