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Algorithmic self-assembly, a generalization of crystal growth processes, has been proposed as a mechanism for autonomous DNA computation and for bottom-up fabrication of complex nanostructures. A `program' for growing a desired structure…

Materials Science · Physics 2010-01-08 Rebecca Schulman , Erik Winfree

Working in Winfree's abstract tile assembly model, we show that a constant-size tile assembly system can be programmed through relative tile concentrations to build an n x n square with high probability, for any sufficiently large n. This…

Computational Complexity · Computer Science 2015-03-13 David Doty

Self assembly is a process by which supramolecular species form spontaneously from their components. This process is ubiquitous throughout the life chemistry and is central to biological information processing. It has been predicted that in…

Information Theory · Computer Science 2009-08-20 Anshul Chaurasia , Sudhanshu Dwivedi , Prateek Jain , Manish K. Gupta

The Pattern self-Assembly Tile set Synthesis (PATS) problem, which arises in the theory of structured DNA self-assembly, is to determine a set of coloured tiles that, starting from a bordering seed structure, self-assembles to a given…

Emerging Technologies · Computer Science 2014-12-24 Mika Göös , Tuomo Lempiäinen , Eugen Czeizler , Pekka Orponen

We propose a mathematical model of DNA self-assembly using 2D tiles to form 3D nanostructures. This is the first work to combine studies in self-assembly and nanotechnology in 3D, just as Rothemund and Winfree did in the 2D case. Our model…

Computational Complexity · Computer Science 2007-05-23 Ming-Yang Kao , Vijay Ramachandran

Self-assembly is a fundamental process by which supramolecular species form spontaneously from their components. This process is ubiquitous throughout the life chemistry and is central to biological information processing. Algorithms for…

Emerging Technologies · Computer Science 2012-07-06 Abhishek Chhajer , Manish K. Gupta , Sandeep Vasani , Jaley Dholakiya

The early promises of DNA computing to deliver a massively parallel architecture well-suited to computationally hard problems have so far been largely unkept. Indeed, it is probably fair to say that only toy problems have been addressed…

Cryptography and Security · Computer Science 2007-05-23 Olivier Pelletier , Andre Weimerskirch

Majumder, Reif and Sahu have presented a stochastic model of reversible, error-permitting, two-dimensional tile self-assembly, and showed that restricted classes of tile assembly systems achieved equilibrium in (expected) polynomial time.…

Computational Complexity · Computer Science 2009-08-04 Aaron Sterling

The Pattern self-Assembly Tile set Synthesis (PATS) problem is to determine a set of coloured tiles that self-assemble to implement a given rectangular colour pattern. We give an exhaustive branch-and-bound algorithm to find tile sets of…

Data Structures and Algorithms · Computer Science 2015-03-13 Mika Göös , Pekka Orponen

Winfree's abstract Tile Assembly Model (aTAM) is a model of molecular self-assembly of DNA complexes known as tiles, which float freely in solution and attach one at a time to a growing "seed" assembly based on specific binding sites on…

Computational Complexity · Computer Science 2015-03-17 Ho-Lin Chen , David Doty , Shinnosuke Seki

DNA Self-Assembly has emerged as an interdisciplinary field with many intriguing applications such DNA bio-sensor, DNA circuits, DNA storage, drug delivery etc. Tile assembly model of DNA has been studied for various computational…

Emerging Technologies · Computer Science 2015-02-20 Shalin Shah , Parth Dave , Manish K Gupta

Branched molecules of deoxyribonucleic acid (DNA) can self-assemble into nanostructures through complementary cohesive strand base pairing. The production of DNA nanostructures is valuable in targeted drug delivery and biomolecular…

Combinatorics · Mathematics 2022-03-15 D. Chloe Griffin , Jessica Sorrells

In this paper we consider the time complexity of computing the sum and product of two $n$-bit numbers within the tile self-assembly model. The (abstract) tile assembly model is a mathematical model of self-assembly in which system…

Data Structures and Algorithms · Computer Science 2013-08-06 Alexandra Keenan , Robert Schweller , Michael Sherman , Xingsi Zhong

The observation by Ke et al. [Science 338, 1177 (2012)] that large numbers of short, pre-designed DNA strands can assemble into three-dimensional target structures came as a great surprise, as no colloidal self-assembling system has ever…

Soft Condensed Matter · Physics 2014-06-12 Aleks Reinhardt , Daan Frenkel

Branched junction molecule assembly of DNA nanostructures, pioneered by Seeman's laboratory in the 1980s, has become increasingly sophisticated, as have the assembly targets. A critical design step is finding minimal sets of branched…

Combinatorics · Mathematics 2021-08-03 Leyda Almodóvar , Jo Ellis-Monaghan , Amanda Harsy , Cory Johnson , Jessica Sorrells

Harnessing the intrinsic dynamics of physical systems for information processing opens new avenues for computation embodied in matter. Using simulations of a model system, we show that assemblies of DNA tiles capable of self-organizing into…

Soft Condensed Matter · Physics 2025-10-23 Tim E. Veenstra , René van Roij , Marjolein Dijkstra

The ability to design and synthesize ever more complicated colloidal particles opens the possibility of self-assembling a zoo of complex structures, including those with one or more self-limited length scales. An undesirable feature of…

Soft Condensed Matter · Physics 2022-03-02 Thomas E. Videbæk , Huang Fang , Daichi Hayakawa , Botond Tyukodi , Michael F. Hagan , W. Benjamin Rogers

Recent advancements in microbiology have motivated the study of the production of nanostructures with applications such as biomedical computing and molecular robotics. One way to construct these structures is to construct branched DNA…

This project mathematically models the self-assembly of DNA nanostructures in the shape of select Archimedean graphs using the flexible tile model. Under three different sets of restrictions called scenarios, we employ principles of linear…

Biomolecules · Quantitative Biology 2025-04-04 Tabitha Merrithew , Jessica Sorrells

Self-assembly is a process found everywhere in the Nature. In particular, it is known that DNA self-assembly is Turing universal. Thus one can do arbitrary computations or build nano-structures using DNA self-assembly. In order to…

Emerging Technologies · Computer Science 2016-07-14 Dixita Limbachiya , Dhaval Trivedi , Manish K Gupta
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