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Mathematical and computational modelling in oncology has played an increasingly important role in not only understanding the impact of various approaches to treatment on tumour growth, but in optimizing dosing regimens and aiding the…

Tissues and Organs · Quantitative Biology 2025-07-03 Molly Brennan , Andrew L. Krause , Edgardo Villar-Sepúlveda , Christopher B. Prior

This paper considers the problem of modeling epidemic outbreaks in different regions with a common model, that uses additional information about these regions to adjust its parameters and relieve us of mundanity of data collecting, and…

Physics and Society · Physics 2024-12-06 Andrei Neverov , Olga Krivorotko

We develop the formulation of turbulence in terms of the functional integral over the phase space configurations of the vortex cells. The phase space consists of Clebsch coordinates at the surface of the vortex cells plus the Lagrange…

High Energy Physics - Theory · Physics 2008-02-03 A. A. Migdal

Defective interfering particles (DIPs) are virus-like particles that occur naturally during virus infections. These particles are defective, lacking essential genetic materials for replication, but they can interact with the wild-type virus…

Quantitative Methods · Quantitative Biology 2024-02-16 Qiantong Liang , Johnny Yang , Wai-Tong Louis Fan , Wing-Cheong Lo

Human mobility is a key factor in spatial disease dynamics and related phenomena. In computational models host mobility is typically modelled by diffusion in space or on metapolulation networks. Alternatively, an effective force of…

Physics and Society · Physics 2012-03-07 Vitaly Belik , Theo Geisel , Dirk Brockmann

We consider a simple deterministic model which describes an asymmetric competition between an immune system with a specific and powerful response, and a virus with a broad toxicity and fast mutations. Interest in this model relies on the…

Quantitative Methods · Quantitative Biology 2011-01-17 Thierry Gobron , Mario Santoro , Livio Triolo

In this paper we study a model of HCV with mitotic proliferation, a saturation infection rate and a discrete intracellular delay: the delay corresponds to the time between infection of a infected target hepatocytes and production of new HCV…

Dynamical Systems · Mathematics 2014-03-13 E. Avila-Vales , N. Chan-Chí , G. García-Almeida , C. Vargas-De-León

Urban areas with larger and more connected populations offer an auspicious environment for contagion processes such as the spread of pathogens. Empirical evidence reveals a systematic increase in the rates of certain sexually transmitted…

Physics and Society · Physics 2018-09-18 Oscar Patterson-Lomba , Andres Gomez-Lievano

Ending the HIV/AIDS pandemic is among the Sustainable Development Goals for the next decade. In order to overcome the gap between the need for care and the available resources, better understanding of HIV epidemics is needed to guide policy…

Applications · Statistics 2020-09-03 Zhou Lan , Le Bao

We propose a stochastic SICA epidemic model for HIV transmission, described by stochastic ordinary differential equations, and discuss its perturbation by environmental white noise. Existence and uniqueness of the global positive solution…

Populations and Evolution · Quantitative Biology 2018-05-30 Jasmina Djordjevic , Cristiana J. Silva , Delfim F. M. Torres

It is the main purpose of this paper to introduce a graph-valued stochastic process in order to model the spread of a communicable infectious disease. The major novelty of the SIR model we promote lies in the fact that the social network on…

Applications · Statistics 2014-02-06 Charanpal Dhanjal , Stéphan Clémençon

A central challenge in Human Immunodeficiency Virus (HIV) public health policy lies in determining whether to universally expand treatment access, despite the risk of sub-optimal adherence and consequent drug resistance, or to adopt a more…

Quantitative Methods · Quantitative Biology 2025-07-16 Ashish Poonia , Siddhartha P. Chakrabarty

The diffusion-driven Turing instability is a potential mechanism for spatial pattern formation in numerous biological and chemical systems. However, engineering these patterns and demonstrating that they are produced by this mechanism is…

Biological Physics · Physics 2025-12-02 Antonio Matas-Gil , Robert G. Endres

A class of reaction-diffusion virus dynamics models with intracellular state-dependent delay and a general non-linear infection rate functional response is investigated. We are interested in classical solutions with Lipschitz in-time…

Dynamical Systems · Mathematics 2019-01-01 Alexander Rezounenko

Introduction. Can the infection due to the human immunodeficiency virus type 1 induce a change in the differentiation status or process in T cells?. Methods. We will consider two stochastic Markov chain models, one which will describe the…

Molecular Networks · Quantitative Biology 2021-02-09 Alfonso Vivanco-Lira , José-Raúl Nieto-Saucedo

In this paper, we investigate the emergence of a predator-prey model with Beddington-DeAngelis-type functional response and reaction-diffusion. We derive the conditions for Hopf and Turing bifurcation on the spatial domain. Based on the…

Populations and Evolution · Quantitative Biology 2008-01-08 Weiming Wang , Lei Zhang , Yakui Xue , Zhen Jin

The SIR model is one of the most prototypical compartmental models in epidemiology. Generalizing this ordinary differential equation (ODE) framework into a spatially distributed partial differential equation (PDE) model is a considerable…

Quantitative Methods · Quantitative Biology 2024-07-11 Su Yang , Weiqi Chu , Panayotis Kevrekidis

Stochasticity and spatial heterogeneity are of great interest recently in studying the spread of an infectious disease. The presented method solves an inverse problem to discover the effectively decisive topology of a heterogeneous network…

Artificial Intelligence · Computer Science 2015-03-13 Yoshiharu Maeno

Pattern formation in reaction-diffusion systems where the diffusion terms correspond to a Sturm-Liouville problem are studied. These correspond to a problem where the diffusion coefficient depends on the spatial variable: $\nabla \cdot…

Pattern Formation and Solitons · Physics 2022-11-28 E. A. Calderón-Barreto , J. L. Aragón

HIV transmission within serodiscordant couples remains a significant public health challenge, particularly in sub-Saharan Africa. Estimating the rate of such infection, alongside the rates of introduction of infection from outside the…

Applications · Statistics 2026-02-05 Irene García Muñoz , Ian Hall , Thomas House
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