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HIV-1 affects tens of millions of people worldwide. Current treatments often involve a cocktail of antiretroviral drugs, which are effective in reducing the virus and extending life spans. However, there is currently no FDA-approved HIV-1…

Populations and Evolution · Quantitative Biology 2020-05-26 Tin Phan , Catherine DeMarino , Fatah Kashanchi , Yang Kuang , Daniel M. Anderson , Maria Emelianenko

The coexistence of different viral strains (quasispecies) within the same host are nowadays observed for a growing number of viruses, most notably HIV, Marburg and Ebola, but the conditions for the formation and survival of new strains have…

Populations and Evolution · Quantitative Biology 2008-01-20 Franco Bagnoli , Pietro Lio' , Luca Sguanci

How topological defects affect the dynamics of particles hopping between lattice sites of a distorted, two-dimensional crystal is addressed. Perturbation theory and numerical simulations show that weak, short-ranged topological disorder…

Statistical Mechanics · Physics 2007-05-23 Ligang Chen , Michael W. Deem

Hyperbolic reaction-diffusion equations have recently attracted attention both for their application to a variety of biological and chemical phenomena, and for their distinct features in terms of propagation speed and novel instabilities…

Pattern Formation and Solitons · Physics 2022-08-17 Joshua Ritchie , Andrew L. Krause , Robert A. Van Gorder

We empirically demonstrate that graphical models can be a valuable tool in the identification of mediating variables in causal pathways. We make use of graphical models to elucidate the causal pathway through which the treatment influences…

Applications · Statistics 2019-07-11 Adrian Dobra , Katherine Buhikire , Joachim G. Voss

We develop an extension of the Susceptible-Infected-Recovery (SIR) model to account for spatial variations in population as well as infection and recovery parameters. The equations are derived by taking the continuum limit of discrete…

Mesoscale and Nanoscale Physics · Physics 2025-02-04 Abhimanyu Ghosh

Turbulent vortex structures emerging in bacterial active fluids can be organized into regular vortex lattices by weak geometrical constraints such as obstacles. Here we show, using a continuum-theoretical approach, that the formation and…

Soft Condensed Matter · Physics 2022-07-06 Henning Reinken , Sebastian Heidenreich , Markus Bär , Sabine H. L. Klapp

Infection by many viruses begins with fusion of viral and cellular lipid membranes, followed by entry of viral contents into the target cell and ultimately, after many biochemical steps, integration of viral DNA into that of the host cell.…

Quantitative Methods · Quantitative Biology 2018-05-10 Bhaven Mistry , Maria R. D'Orsogna , Nicholas E. Webb , Benhur Lee , Tom Chou

There is growing recognition in both the experimental and modelling literature of the importance of spatial structure to the dynamics of viral infections in tissues. Aided by the evolution of computing power and motivated by recent…

Quantitative Methods · Quantitative Biology 2025-07-08 Thomas Williams , James M. McCaw , James M. Osborne

Infectious diseases are caused by pathogenic microorganisms and can spread through different ways. Mathematical models and computational simulation have been used extensively to investigate the transmission and spread of infectious…

In this paper, the Turing instability in reaction-diffusion models defined on complex networks is studied. Here, we focus on three types of models which generate complex networks, i.e. the Erd\H{o}s-R\'enyi, the Watts-Strogatz, and the…

Pattern Formation and Solitons · Physics 2016-04-22 Yusuke Ide , Hirofumi Izuhara , Takuya Machida

In this article, we consider an HIV/AIDS epidemic model with four classes of individuals. We have discussed about basic properties of the system and found the basic reproduction number $R_0$ of the system. The stability analysis of the…

Dynamical Systems · Mathematics 2023-04-18 Nouar Chorfi , Salem Abdelmalek , Samir Bendoukha

As the global HIV pandemic enters its fourth decade, increasing numbers of surveillance sites have been established which allows countries to look into the epidemics at a finer scale, e.g. at sub-national level. However, the epidemic models…

Applications · Statistics 2014-11-18 Le Bao , Mary Mahy , Xiaoyue Niu , Tim Brown , Peter Ghys

During the spreading of epithelial tissues, the advancing tissue front often develops fingerlike protrusions. Their resemblance to traditional viscous fingering patterns in driven fluids suggests that epithelial fingers could arise from an…

Biological Physics · Physics 2019-03-05 Ricard Alert , Carles Blanch-Mercader , Jaume Casademunt

Symmetry-breaking instabilities play an important role in understanding the mechanisms underlying the diversity of patterns observed in nature, such as in Turing's reaction--diffusion theory, which connects cellular signalling and transport…

Pattern Formation and Solitons · Physics 2023-12-25 Andrew L. Krause , Eamonn A. Gaffney , Thomas Jun Jewell , Václav Klika , Benjamin J. Walker

A new statistical approach is presented to study the thermal instability process of optically thin unmagnetized plasma. In this approach the time evolution of mass distribution function over temperature is calculated. This function…

Astrophysics · Physics 2009-10-30 A. F. Illarionov , I. V. Igumenshchev

We present a comprehensive statistical methodological framework for estimating contextual exposure to HIV that includes local (grid-cell level) estimation of HIV prevalence and human activity space estimation based on GPS data. The…

Partial differential equation (PDE) models for infectious diseases, while less common than their ordinary differential equation (ODE) counterparts, have found successful applications for many years. Such models are typically of…

Populations and Evolution · Quantitative Biology 2026-01-27 Alex Viguerie , Malú Grave , Alvaro L. G. A. Coutinho , Alessandro Veneziani , Thomas J. R. Hughes

The complex and dynamic crosstalk between tumour and immune cells results in tumours that can exhibit distinct qualitative behaviours - elimination, equilibrium, and escape - and intricate spatial patterns, yet share similar cell…

We consider multiple diseases spreading in a static Configuration Model network. We make standard assumptions that infection transmits from neighbor to neighbor at a disease-specific rate and infected individuals recover at a…

Populations and Evolution · Quantitative Biology 2015-06-11 Joel C. Miller
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