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A simple, heuristic formula with parallels to the Drake Equation is introduced to help focus discussion on open questions for the origins of life in a planetary context. This approach indicates a number of areas where quantitative progress…

Earth and Planetary Astrophysics · Physics 2016-08-17 Caleb Scharf , Leroy Cronin

The claim that life is an emergent phenomenon exhibiting novel properties and principles is often criticized for being in conflict with causal closure at the microscopic level. I argue that advances in cosmological theory suggesting an…

Astrophysics · Physics 2007-05-23 P. C. W. Davies

A central and long-standing issue in evolutionary theory is the origin of the biological variation upon which natural selection acts1. Some hypotheses suggest that evolutionary change represents an adaptation to the surrounding environment…

Statistical Mechanics · Physics 2007-05-23 J. Podani , Z. N. Oltvai , H. Jeong , B. Tombor , A. -L. Barabasi , E. Szathmary

It has been proposed that cultural evolution was made possible by a cognitive transition brought about by onset of the capacity for self-triggered recall and rehearsal. Here we develop a novel idea that models of collectively autocatalytic…

Neurons and Cognition · Quantitative Biology 2017-08-09 Liane Gabora , Mike Steel

The present view of biological phenomena is based on a biochemical paradigm that development of living organisms is defined by information stored in a molecular form as some genetic code. However, new discoveries indicate that biological…

Other Quantitative Biology · Quantitative Biology 2023-11-14 Yuri K. Shestopaloff

Why life is complex and --most importantly-- what is the origin of the over abundance of complexity in nature? This is a fundamental scientific question which, paraphrasing the late Per Bak, "is screaming to be answered but seldom is even…

Other Quantitative Biology · Quantitative Biology 2019-01-30 Dante R. Chialvo

We propose a novel definition of life in terms of which its emergence in the universe is expected, and its ever-creative open-ended evolution is entailed by no law. Living organisms are Kantian Wholes that achieve Catalytic Closure,…

Populations and Evolution · Quantitative Biology 2024-04-11 Stuart Kauffman , Andrea Roli

According to the "hard-steps" model, the origin of humanity required "successful passage through a number of intermediate steps" (so-called "hard" or "critical" steps) that were intrinsically improbable with respect to the total time…

Populations and Evolution · Quantitative Biology 2025-02-18 Daniel B. Mills , Jennifer L. Macalady , Adam Frank , Jason T. Wright

In this paper we review and extend our earlier recent work on thermostated systems. A description of nano-biological systems by Markov chains in coordinate space in the strongly overdamped limit is presented. Characterization of the most…

Subcellular Processes · Quantitative Biology 2015-12-01 Ronald F. Fox

Living organisms are not just random collections of organic molecules. There is continuous information processing going on in the apparent bouncing around of molecules of life. Optimisation criteria in this information processing can be…

Quantum Physics · Physics 2007-05-23 Apoorva Patel

We provide a novel approach and an exploratory study for modelling life event choices and occurrence from a probabilistic perspective through causal discovery and survival analysis. Our approach is formulated as a bi-level problem. In the…

Information flow provides a natural measure for the causal interaction between dynamical events. This study extends our previous rigorous formalism of componentwise information flow to the bulk information flow between two complex…

Neurons and Cognition · Quantitative Biology 2021-12-30 X. San Liang

Life is commonly described as a self-organized, far-from-equilibrium process that maintains internal order by consuming free energy and exporting entropy. This thermodynamic view underlies diverse theoretical frameworks -- from autopoiesis…

Biological Physics · Physics 2025-12-23 Didier Sornette , Virgile Troude

Biological systems reach hierarchical complexity that has no counterpart outside the realm of biology. Undoubtedly, biological entities obey the fundamental physical laws. Can today's physics provide an explanatory framework for…

Statistical Mechanics · Physics 2022-10-12 Yuri I. Wolf , Mikhail I. Katsnelson , Eugene V. Koonin

One of the most compelling problems in science consists in understanding how living systems process information. After all, the way they process information defines their capacities to learning and adaptation. There is an increasing…

Adaptation and Self-Organizing Systems · Physics 2017-04-21 Carlos Eduardo Maldonado

Life on earth is distinguished by long-lived correlations in time. The patterns of material organization that characterize living organisms today are contingent on events that occurred billions of years ago. This contingency is a necessary…

Soft Condensed Matter · Physics 2021-01-06 Peter M. Tzelios , Kyle J. M. Bishop

The biological hierarchy and the differences between living and non-living systems are considered from the standpoint of quantum mechanics. The hierarchical organization of biological systems requires hierarchical organization of quantum…

Quantum Physics · Physics 2007-05-23 M. V. Altaisky

Many biological processes can be thought of as the result of an underlying dynamics in which the system repeatedly undergoes distinct and abortive trajectories with the dynamical process only ending when some specific process, purpose,…

Biological Physics · Physics 2025-06-05 Jane Kondev , Marc Kirschner , Hernan G. Garcia , Gabriel L. Salmon , Rob Phillips

The origin of life is often framed primarily as a chemical problem, yet life's defining feature is evolution. Advances in geochemistry, prebiotic chemistry, and molecular biology have produced diverse scenarios for the emergence of genomes,…

The fields of Origin of Life and Artificial Life both question what life is and how it emerges from a distinct set of "pre-life" dynamics. One common feature of most substrates where life emerges is a marked shift in dynamics when…

Neural and Evolutionary Computing · Computer Science 2024-08-05 Blaise Agüera y Arcas , Jyrki Alakuijala , James Evans , Ben Laurie , Alexander Mordvintsev , Eyvind Niklasson , Ettore Randazzo , Luca Versari