Related papers: Influenza Virus Vaccine Efficacy Based On Conserve…
We consider the interplay of vaccination and migration rates on disease persistence in epidemiological systems. We show that short-term and long-term migration can inhibit disease persistence. As a result, we show how migration changes how…
Refined vaccine regimens containing variant-matched inserts are often authorized based on historical phase 3 efficacy trials together with immunobridging studies. Phase 3 trials are essential for establishing immune biomarkers that reliably…
Background: African swine fever is among the most devastating viral diseases of pigs. Despite nearly a century of research, there is still no safe and effective vaccine available. The current situation is that either vaccines are safe but…
With the emergence and spread of infectious diseases with pandemic potential, such as COVID- 19, the urgency for vaccine development have led to unprecedented compressed and accelerated schedules that shortened the standard development…
Conventional wisdom holds that influenza A and B are such genetically dissimilar viruses that infection with one cannot confer cross-immunity to the other. However, our examination of the records of the past 25 influenza seasons in the U.S.…
Early detection of person-to-person transmission of emerging infectious diseases such as avian influenza is crucial for containing pandemics. We developed a simple permutation test and its refined version for this purpose. A simulation…
Studies of vaccine efficacy often record both the incidence of vaccine-targeted virus strains (primary outcome) and the incidence of non-targeted strains (secondary outcome). However, standard estimates of vaccine efficacy on targeted…
The test-negative design (TND) has become a standard approach to evaluate vaccine effectiveness against the risk of acquiring infectious diseases in real-world settings, such as Influenza, Rotavirus, Dengue fever, and more recently…
With COVID-19 having emerged as the most widespread human pandemic disease in a century, the need to control its spread to avoid massive loss of life became more than necessary, and extremely fast. Several vaccines were developed and the…
Preventing infectious disease like flu from spreading to large communities is one of the most important issues for humans. One effective strategy is voluntary vaccination, however, there is always the temptation for people refusing to be…
Influenza occurs every season and occasionally causes pandemics. Despite its low mortality rate, influenza is a major public health concern, as it can be complicated by severe diseases like pneumonia. A fast, accurate and low-cost method to…
Background: Network-based interventions are most powerful against epidemics when the full network structure is known. However, resource constraints often require decisions based on partial network data. We investigated how the effectiveness…
The dynamics of strongly immunizing childhood infections is still not well understood. Although reports of successful modeling of several incidence data records can be found in the literature, the key determinants of the observed temporal…
The vaccination against ongoing epidemics is seldom compulsory but remains one of the most classical means to fight epidemic propagation. However recent debates concerning the innocuity of vaccines and their risk with respect to the risk of…
Differing opinions about COVID-19 have led to various online discourses regarding vaccines. Due to the detrimental effects and the scale of the COVID-19 pandemic, detecting vaccine stance has become especially important and is attracting…
Each year, seasonal influenza epidemics cause hundreds of thousands of deaths worldwide and put high loads on health care systems. A main concern for resource planning is the risk of exceptionally severe epidemics. Taking advantage of…
Infectious diseases cause more than 13 million deaths a year, worldwide. Globalization, urbanization, climate change, and ecological pressures have significantly increased the risk of a global pandemic. The ongoing COVID-19 pandemic-the…
The emerging threat of a human pandemic caused by the H5N1 avian influenza virus strain magnifies the need for controlling the incidence of H5N1 infection in domestic bird populations. Culling is one of the most widely used control measures…
In this paper, the authors develop a method of detecting correlations between epidemic patterns in different regions that are due to human movement and introduce a null model in which the travel-induced correlations are cancelled. They…
In this paper, we analyze the temporal evolution of the age-dependent force of infection and incidence of rubella, after the introduction of a very specific vaccination programme in a previously nonvaccinated population where rubella was in…