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We describe the construction and theoretical analysis of a framework derived from canonical neurophysiological principles that model the competing dynamics of incident signals into nodes along directed edges in a network. The framework…

Neurons and Cognition · Quantitative Biology 2019-08-06 Gabriel A. Silva

This paper presents an algorithm for approximating certain types of dynamical systems given by a system of ordinary delay differential equations by a Boolean network model. Often Boolean models are much simpler to understand than complex…

Molecular Networks · Quantitative Biology 2011-05-10 Franziska Hinkelmann , Reinhard Laubenbacher

Based on a non-equilibrium mechanism for spatial pattern formation we study how position information can be controlled by locally coupled discrete dynamical networks, similar to gene regulation networks of cells in a developing…

Molecular Networks · Quantitative Biology 2009-08-26 Thimo Rohlf , Stefan Bornholdt

We study the current response to periodic driving of a crucial biochemical reaction network, namely, substrate inhibition. We focus on the conversion rate of substrate into product under time-varying metabolic conditions, modeled by a…

Statistical Mechanics · Physics 2020-04-20 Danilo Forastiere , Gianmaria Falasco , Massimiliano Esposito

The collective dynamics of a network of excitable nodes changes dramatically when inhibitory nodes are introduced. We consider inhibitory nodes which may be activated just like excitatory nodes but, upon activating, decrease the probability…

Neurons and Cognition · Quantitative Biology 2014-04-03 Daniel B. Larremore , Woodrow L. Shew , Edward Ott , Francesco Sorrentino , Juan G. Restrepo

Turing instability in activator-inhibitor systems provides a paradigm of nonequilibrium pattern formation; it has been extensively investigated for biological and chemical processes. Turing pattern formation should furthermore be possible…

Adaptation and Self-Organizing Systems · Physics 2010-05-13 Hiroya Nakao , Alexander S. Mikhailov

Gamma-band rhythmic inhibition is a ubiquitous phenomenon in neural circuits yet its computational role still remains elusive. We show that a model of Gamma-band rhythmic inhibition allows networks of coupled cortical circuit motifs to…

Neurons and Cognition · Quantitative Biology 2017-11-08 Hesham Mostafa , Lorenz K. Muller , Giacomo Indiveri

The Turing patterning mechanism is believed to underly the formation of repetitive structures in development, such as zebrafish stripes and mammalian digits, but it has proved difficult to isolate the specific biochemical species…

Molecular Networks · Quantitative Biology 2018-03-22 Stephen Smith , Neil Dalchau

Immune cells recognize and discriminate antigens through immunological synapses - dynamic intercellular junctions exhibiting highly organized receptor-ligand patterns. While much work has focused on molecular kinetics and passive mechanisms…

Cell Behavior · Quantitative Biology 2025-10-22 Tony Wong , Tom Chou , Suraj Shankar , Shenshen Wang

Stylized models of the neurodynamics that underpin sensory motor control in animals are proposed and studied. The voluntary motions of animals are typically initiated by high level intentions created in the primary cortex through a…

Systems and Control · Electrical Eng. & Systems 2021-10-12 John Baillieul , Zexin Sun

Surface soliton formation and lattice soliton dynamics at an interface between two inhomogeneous periodic media are studied in terms of an effective particle approach. The global reflection, transmission and trapping characteristics are…

Pattern Formation and Solitons · Physics 2009-11-13 Yannis Kominis , Kyriakos Hizanidis

We analyse a dynamic control problem for scalar reaction-diffusion equations, focusing on the emulation of pattern formation through the selection of appropriate active controls. While boundary controls alone prove inadequate for…

Optimization and Control · Mathematics 2024-07-26 Domènec Ruiz-Balet , Enrique Zuazua

Recent advances in high-resolution experimental methods have highlighted the significance of cell signal pathway crosstalk and localised signalling activity in the development and disease of numerous biological systems. The investigation of…

Dynamical Systems · Mathematics 2022-09-19 Joshua W. Moore , Trevor C. Dale , Thomas E. Woolley

A novel mechanism for cell differentiation is proposed, based on the dynamic clustering in a globally coupled chaotic system. A simple model with metabolic reaction, active transport of chemicals from media, and cell division is found to…

adap-org · Physics 2009-10-22 Kunihiko Kaneko , Tetsuya Yomo

Bacteria can form a great variety of spatially heterogeneous cell density patterns, ranging from simple concentric rings to dynamical spiral waves appearing in growing colonies. These pattern formation phenomena are important as they…

Populations and Evolution · Quantitative Biology 2025-01-17 John S. Chuang , Riccardo Rao , Stanislas Leibler

We propose an approach for learning the causal structure in stochastic dynamical systems with a $1$-step functional dependency in the presence of latent variables. We propose an information-theoretic approach that allows us to recover the…

Information Theory · Computer Science 2017-01-25 Saber Salehkaleybar , Jalal Etesami , Negar Kiyavash

Dynamic facilitation theory assumes short-ranged dynamic constraints to be the essential feature of supercooled liquids and draws much of its conclusions from the study of kinetically constrained models. While deceptively simple, these…

Materials Science · Physics 2012-06-12 Thomas Speck , David Chandler

The main objective of this article is to study the order-disorder phase transition and pattern formation for systems with long-range repulsive interactions. The main focus is on the Cahn-Hilliard model with a nonlocal term in the…

Statistical Mechanics · Physics 2011-06-21 Honghu Liu , Taylan Sengul , Shouhong Wang , Pingwen Zhang

The behaviour of many real-world phenomena can be modelled by nonlinear dynamical systems whereby a latent system state is observed through a filter. We are interested in interacting subsystems of this form, which we model by a set of…

Machine Learning · Computer Science 2017-02-20 Oliver M. Cliff , Mikhail Prokopenko , Robert Fitch

Mathematical models of stem cell differentiation are commonly based upon the concept of subsequent cell fate decisions, each controlled by a gene regulatory network. These networks exhibit a multistable behavior and cause the system to…

Quantitative Methods · Quantitative Biology 2011-07-06 Christian Breindl , Daniella Schittler , Steffen Waldherr , Frank Allgöwer
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