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Traditional top-down robotic design often lacks the adaptability needed to handle real-world complexities, prompting the need for more flexible approaches. Therefore, this study introduces a novel cellular plasticity model tailored for…

Robotics · Computer Science 2024-08-13 Trevor R. Smith , Thomas J. Smith , Nicholas S. Szczecinski , Sergiy Yakovenko , Yu Gu

The proper functioning of multicellular organisms requires the robust establishment of precise proportions between distinct cell-types. This developmental differentiation process typically involves intracellular regulatory and stochastic…

Cell Behavior · Quantitative Biology 2016-06-22 Benjamin Pfeuty , Kunihiko Kaneko

Inspired by active shape morphing in developing tissues and biomaterials, we investigate two generic mechanochemical models where the deformations of a thin elastic sheet are driven by, and in turn affect, the concentration gradients of a…

Soft Condensed Matter · Physics 2021-07-14 Andrei Zakharov , Kinjal Dasbiswas

Rhythmic and sequential segmentation of the embryonic body plan is a vital developmental patterning process in all vertebrate species. However, a theoretical framework capturing the emergence of dynamic patterns of gene expression from the…

Biological Physics · Physics 2016-10-12 David J. Jörg , Andrew C. Oates , Frank Jülicher

We demonstrate that active rotations in chemically signalling particles, such as autochemotactic {\it E. coli} close to walls, create a route for pattern formation based on a nonlinear yet deterministic instability mechanism. For slow…

Soft Condensed Matter · Physics 2016-08-19 Benno Liebchen , Michael E. Cates , Davide Marenduzzo

Multicellular organisms contain a wide variety of highly specialized cell types. The consistency and robustness of developmental trajectories suggest that complex gene regulatory networks effectively act as low-dimensional cell fate…

Cell Behavior · Quantitative Biology 2026-05-28 Maria Yampolskaya , Laertis Ikonomou , Pankaj Mehta

Directed information transmission is paramount for many social, physical, and biological systems. For neural systems, scientists have studied this problem under the paradigm of feedforward networks for decades. In most models of feedforward…

Neurons and Cognition · Quantitative Biology 2017-11-21 Yazan N. Billeh , Michael T. Schaub

Cellular checkerboard patterns are observed at many developmental stages of embryos. We study an analytically tractable model for lateral inhibition and show that a coupling coefficient with a negative value is sufficient to obtain noisy or…

Biological Physics · Physics 2019-05-01 Jose Negrete , Andrew C. Oates

Biological systems are majorly dependent on their property of bistability in order to exhibit nongenetic heterogeneity in terms of cellular morphology and physiology. Spatial patterns of phenotypically heterogeneous cells, arising due to…

Quantitative Methods · Quantitative Biology 2023-01-25 Priya Chakraborty , Ushasi Roy , Mohit K. Jolly , Sayantari Ghosh

The understanding of neural activity patterns is fundamentally linked to an understanding of how the brain's network architecture shapes dynamical processes. Established approaches rely mostly on deviations of a given network from certain…

Neurons and Cognition · Quantitative Biology 2014-09-19 Marc-Thorsten Huett , Marcus Kaiser , Claus C. Hilgetag

Reverberating dynamics of neural network is modelled on PC in order to illustrate possible role of inhibition as binding controller in the network. The network is composed of binding neurons. In the binding neuron model the degree of…

Neurons and Cognition · Quantitative Biology 2013-05-17 Alexander Vidybida

We consider the modeling, stability analysis and controller design problems for discrete-time LTI systems with state feedback, when the actuation signal is subject to switching propagation delays, due to e.g. the routing in a multi-hop…

Optimization and Control · Mathematics 2014-01-09 R. M. Jungers , A. D'Innocenzo , M. D. Di Benedetto

The phenomenon of pattern formation in nonlinear optical resonators is commonly related to an off-resonance excitation mechanism, where patterns occur due to mismatch between the excitation and resonance frequency. In this paper we show…

Pattern Formation and Solitons · Physics 2009-10-31 Kestutis Staliunas , Victor J. Sanchez-Morcillo

Intracellular transport processes driven by molecular motors can be described by stochastic lattice models of self-driven particles. Here we focus on bidirectional transport models excluding the exchange of particles on the same track. We…

Biological Physics · Physics 2015-05-27 M. Ebbinghaus , C. Appert-Rolland , L. Santen

Spatiotemporal patterns are common in biological systems. For electrically-coupled cells previous studies of pattern formation have mainly used external forcing as the main bifurcation parameter. The purpose of this paper is to show that…

Dynamical Systems · Mathematics 2021-11-02 H. O. Fatoyinbo , R. G. Brown , D. J. W. Simpson , B. van Brunt

A dynamic model for cell differentiation is studied, where cells with internal chemical reaction dynamics interact with each other and replicate. It leads to spontaneous differentiation of cells and determination, as is discussed in the…

adap-org · Physics 2007-05-23 Chikara Furusawa , Kunihiko Kaneko

Driven particles in presence of crowded environment, obstacles or kinetic constraints often exhibit negative differential mobility (NDM) due to their decreased dynamical activity. We propose a new mechanism for complex many-particle systems…

Statistical Mechanics · Physics 2018-06-06 Amit Kumar Chatterjee , Urna Basu , P. K. Mohanty

To be effective, efficient, and diverse, deep learning models need to dynamically choose its architecture based on signals from a population of neurons. We hypothesize dynamic routing models can be improved with neural inhibition in those…

Machine Learning · Computer Science 2025-07-08 Will Y. Zou , Jennifer Y. Zhang

Two identical van der Pol oscillators with mutual inhibition are considered as a conceptual framework for modeling a latching mechanism for cell cycle regulation. In particular, the oscillators are biased to a latched state in which there…

Dynamical Systems · Mathematics 2024-12-13 Punit Gandhi , Yangyang Wang

The slow dynamics of nearly stationary patterns in a FitzHugh-Nagumo model are studied using a phase dynamics approach. A Cross-Newell phase equation describing slow and weak modulations of periodic stationary solutions is derived. The…

Pattern Formation and Solitons · Physics 2009-10-31 Aric Hagberg , Ehud Meron , Thierry Passot