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We investigate dynamics of a kinetic model of inhibitory autoregulation as exemplified when a protein inhibits its own production by interfering with its messenger RNA, known in molecular biology as translational autoregulation. We first…

Molecular Networks · Quantitative Biology 2019-01-09 Vivian Tyng , Michael E. Kellman

We disclose the generality of the intrinsic mechanisms underlying multistability in reciprocally inhibitory 3-cell circuits composed of simplified, low-dimensional models of oscillatory neurons, as opposed to those of a detailed Hodgkin-…

Adaptation and Self-Organizing Systems · Physics 2020-08-26 J. Collens , K. Pusuluri , A. Kelly , D. Knapper , T. Xing , S. Basodi , D. Alacam , A. L. Shilnikov

A stochastic model of excitatory and inhibitory interactions which bears universality traits is introduced and studied. The endogenous component of noise, stemming from finite size corrections, drives robust inter-nodes correlations, that…

Disordered Systems and Neural Networks · Physics 2017-08-16 Clement Zankoc , Duccio Fanelli , Francesco Ginelli , Roberto Livi

For many networks, the connection pattern (often called the topology) can vary in time, depending on the changing state, or mode, of the modules within the network. For example, "airplane mode" is the name for one communicative mode of a…

Dynamical Systems · Mathematics 2015-12-15 David I. Spivak , Joshua Z. Tan

The behavior of the network and its stability are governed by both dynamics of individual nodes as well as their topological interconnections. Attention mechanism as an integral part of neural network models was initially designed for…

Machine Learning · Computer Science 2022-12-20 Nooshin Bahador , Milad Lankarany

Many biological systems dynamically rearrange their components through a sequence of configurations in order to perform their functions. Such dynamic processes have been studied using network models that sequentially retrieve a set of…

Statistical Mechanics · Physics 2022-12-01 Lukas Herron , Pablo Sartori , BingKan Xue

Periodic patterns in dynamical behaviours of biological models described by simple form differential delay equations are studied. Mathematical models are given by a class of scalar delay differential equations with a multiplicative time…

Dynamical Systems · Mathematics 2025-10-01 A. Ivanov , S. Shelyag

A Markovian model of the evolution of intermittent connections of various classes in a communication network is established and investigated. Any connection evolves in a way which depends only on its class and the state of the network, in…

Networking and Internet Architecture · Computer Science 2010-08-23 Carl Graham , Philippe Robert

Based on a recently proposed non-equilibrium mechanism for spatial pattern formation [cond-mat/0312366] we study how morphogenesis can be controlled by locally coupled discrete dynamical networks, similar to gene regulation networks of…

Molecular Networks · Quantitative Biology 2007-05-23 Thimo Rohlf , Stefan Bornholdt

Coupled relaxation oscillators, realized via chemical or other means, can exhibit a multiplicity of steady states, characterized by spatial patterns resulting from lateral inhibition. We show that perturbation-initiated transformations…

Pattern Formation and Solitons · Physics 2023-06-22 A. Parveena Shamim , Shakti N. Menon , Sitabhra Sinha

We define a class of dynamical systems by modifying a construction due to Tao, which includes certain Furstenburg limits arising from the Liouville function. Most recent progress on the Chowla conjectures and sign patterns of the Mobius and…

Number Theory · Mathematics 2018-09-11 Will Sawin

In this paper we present a study of pattern formation in bidimensional systems with competing short-range attractive and long-range repulsive interactions. The interaction parameters are chosen in such a way to analyse two different…

Soft Condensed Matter · Physics 2007-05-23 A. Imperio , L. Reatto

Signaling networks are designed to sense an environmental stimulus and adapt to it. We propose and study a minimal model of signaling network that can sense and respond to external stimuli of varying strength in an adaptive manner. The…

Molecular Networks · Quantitative Biology 2010-09-14 Subhadip Raychaudhuri

The presence of one or more species at some spatial locations but not others is a central matter in ecology. This phenomenon is related to ecological pattern formation. Nonlocal interactions can be considered as one of the mechanisms…

Populations and Evolution · Quantitative Biology 2017-12-29 Ozgur Aydogmus

During development, spatio-temporal patterns ranging from checkerboard to engulfing occur with precise proportions of the respective cell fates. Key developmental regulators are intracellular transcriptional interactions and intercellular…

Biological Physics · Physics 2022-11-15 Simon Schardt , Sabine C. Fischer

In experiments on model membranes, a formation of large domains of different lipid composition is readily observed. However, no such phase separation is observed in the membranes of intact cells. Instead, a structure of small transient…

Soft Condensed Matter · Physics 2017-08-23 Timo Fischer , H. Jelger Risselada , Richard L. C. Vink

Multipotent stem or progenitor cells undergo a sequential series of binary fate decisions, which ultimately generate the diversity of differentiated cells. Efforts to understand cell fate control have focused on simple gene regulatory…

Molecular Networks · Quantitative Biology 2009-09-15 David V. Foster , Jacob G. Foster , Sui Huang , Stuart A. Kauffman

We target modeling latent dynamics in high-dimension marked event sequences without any prior knowledge about marker relations. Such problem has been rarely studied by previous works which would have fundamental difficulty to handle the…

Machine Learning · Computer Science 2019-10-29 Qitian Wu , Zixuan Zhang , Xiaofeng Gao , Junchi Yan , Guihai Chen

Biological systems encode function not primarily in steady states, but in the structure of transient responses elicited by time-varying stimuli. Overshoots, biphasic dynamics, adaptation kinetics, fold-change detection, entrainment, and…

Quantitative Methods · Quantitative Biology 2026-01-05 Eduardo D. Sontag

The identification of the limiting factors in the dynamical behavior of complex systems is an important interdisciplinary problem which often can be traced to the spectral properties of an underlying network. By deriving a general relation…

Disordered Systems and Neural Networks · Physics 2007-07-03 Adilson E. Motter