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Transcription factors (TFs) are key regulators of gene expression. Based on the classical scenario in which the TF search process switches between one-dimensional motion along the DNA molecule and free Brownian motion in the nucleus, we…

Genomics · Quantitative Biology 2010-10-15 Godefroy Malherbe , David Holcman

We propose another integrate-and-fire model as a single neuron model. We study a globally coupled noisy integrate-and-fire model with inhibitory interaction using the Fokker-Planck equation and the Langevin equation, and find a reentrant…

Neurons and Cognition · Quantitative Biology 2009-11-11 H. Sakaguchi , S. Tobiishi

Nonlinear oscillator systems are ubiquitous in biology and physics, and their control is a practical problem in many experimental systems. Here we study this problem in the context of the two models of spatially-coupled oscillators: the…

Pattern Formation and Solitons · Physics 2021-04-21 Alexander Golden , Allyson E. Sgro , Pankaj Mehta

We explore the dynamics of an integrate-and-fire neuron with an oscillatory stimulus. The frustration due to the competition between the neuron's natural firing period and that of the oscillatory rhythm, leads to a rich structure of…

Statistical Mechanics · Physics 2013-05-29 Jan R. Engelbrecht , Renato Mirollo

Entrainment experiments on the vertebrate segmentation clock have revealed that embryonic oscillators actively change their internal frequency to adapt to the driving signal. This is neither consistent with a one-dimensional clock model nor…

Biological Physics · Physics 2024-08-27 Christian Mauffette Denis , Paul François

Nonautonomous driving of an oscillator has been shown to enlarge the Arnold tongue in parameter space, but little is known about the analogous effect for a network of oscillators. To test the hypothesis that deterministic nonautonomous…

Adaptation and Self-Organizing Systems · Physics 2019-01-16 Maxime Lucas , Duccio Fanelli , Aneta Stefanovska

Cells sense their surrounding by employing intracellular signaling pathways that transmit hormonal signals from the cell membrane to the nucleus. TGF-$\beta$/SMAD signaling encodes various cell fates, controls tissue homeostasis and is…

Molecular Networks · Quantitative Biology 2022-10-12 Niklas Kolbe , Lorenz Hexemer , Lukas-Malte Bammert , Alexander Loewer , Mária Lukáčová-Medviďová , Stefan Legewie

We have conducted experiments to probe how the dynamics of nanocontact vortex oscillators can be modulated by an external signal. We explore the phase-locking properties in both the commensurate and chaotic regimes, where chaos appears to…

Mesoscale and Nanoscale Physics · Physics 2019-10-25 Jérémy Létang , Sébastien Petit-Watelot , Myoung-Woo Yoo , Thibaut Devolder , Karim Bouzehouane , Vincent Cros , Joo-Von Kim

The Fitzhugh-Nagumo neuronal model is used to explore the influence of the electric field on thermosensitive neurons' dynamics. This study investigates how the electric field affects polarization modulation in cell media induced by changes…

Chaotic Dynamics · Physics 2025-02-13 Ediline L. F. Nguessap , Fernando F. Ferreira , Antonio C. Roque

The influence of random fluctuations on the recruitment of effector cells towards a tumor is studied by means of a stochastic mathematical model. Aggressively growing tumors are confronted against varying intensities of the cell-mediated…

Other Quantitative Biology · Quantitative Biology 2020-10-28 Irina Bashkirtseva , Lev Ryashko , Álvaro G. López , Jesus M. Seoane , Miguel A. F. Sanjuán

The TGF-beta pathway plays a central role in tissue homeostasis and morphogenesis. It transduces a variety of extracellular signals into intracellular transcriptional responses that control a plethora of cellular processes, including cell…

Molecular Networks · Quantitative Biology 2007-05-23 Jose M. G. Vilar , Ronald Jansen , Chris Sander

We consider a three-state model comprising tumor cells, effector cells and tumor detecting cells under the influence of noises. It is demonstrated that inevitable stochastic forces existing in all three cell species are able to suppress…

Tissues and Organs · Quantitative Biology 2011-07-05 Thomas Bose , Steffen Trimper

Synchronisation and stability under periodic oscillatory driving are well-understood, but little is known about the effects of aperiodic driving, despite its abundance in nature. Here, we consider oscillators subject to driving with slowly…

Adaptation and Self-Organizing Systems · Physics 2018-05-09 Maxime Lucas , Julian Newman , Aneta Stefanovska

We investigate the modes of oscillation of heterogeneous ring-networks of quadratic integrate-and-fire neurons with non-local, space-dependent coupling. Perturbations of the equilibrium state with a particular wave number produce transient…

Neurons and Cognition · Quantitative Biology 2017-11-15 Jose M. Esnaola-Acebes , Alex Roxin , Daniele Avitabile , Ernest Montbrió

Eukaryotic cells can move spontaneously without being guided by external cues. For such spontaneous movements, a variety of different modes have been observed, including the amoeboid-like locomotion with protrusion of multiple pseudopods,…

Cell Behavior · Quantitative Biology 2009-03-16 Shin I. Nishimura , Masahiro Ueda , Masaki Sasai

Non-genetic heterogeneity is key to cellular decisions, as even genetically identical cells respond in very different ways to the same external stimulus, e.g., during cell differentiation or therapeutic treatment of disease. Strong…

Molecular Networks · Quantitative Biology 2020-07-20 Uddipan Sarma , Lorenz Hexemer , Uchenna Alex Anyaegbunam , Stefan Legewie

Astrocytes play a central role in inducing concerted phase synchronized neural-wave patterns inside the brain. In this article, we demonstrate that injected radio-frequency signal in underlying heavy metal layer of spin-orbit torque…

Emerging Technologies · Computer Science 2021-09-17 Umang Garg , Kezhou Yang , Abhronil Sengupta

We investigate the possibility that narrowband oscillations may emerge from completely asynchronous, independent neural firing. We find that a population of asynchronous neurons may produce narrowband oscillations if each neuron fires…

Neurons and Cognition · Quantitative Biology 2015-12-08 Stephen V. Gliske , Eugene Lim , Katherine A. Holman , William C. Stacey , Christian G. Fink

Cell signaling, gene expression, and metabolism are affected by cell-cell heterogeneity and random changes in the environment. The effects of such fluctuations on cell signaling and gene expression have recently been studied intensively…

Biological Physics · Physics 2015-04-02 A. -K. Gustavsson , C. B. Adiels , B. Mehlig , M. Goksör

We study the synchronization of dissipatively-coupled van der Pol oscillators in the quantum limit, when each oscillator is near its quantum ground state. Two quantum oscillators with different frequencies exhibit an entanglement tongue,…

Quantum Physics · Physics 2014-02-14 Tony E. Lee , Ching-Kit Chan , Shenshen Wang