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Photon counting CT (PCCT) has been a research focus in the last two decades. Recent studies and advancements have demonstrated that systems using semiconductor-based photon counting detectors (PCDs) have the potential to provide better…

We recently built an analytical source model for GPU-based MC dose engine. In this paper, we present a sampling strategy to efficiently utilize this source model in GPU-based dose calculation. Our source model was based on a concept of…

Medical Physics · Physics 2015-03-06 Zhen Tian , Michael Folkerts , Yongbao Li , Feng Shi , Steve B. Jiang , Xun Jia

The high precision and conformity of intensity-modulated particle therapy (IMPT) comes at the cost of susceptibility to treatment uncertainties in particle range and patient set-up. Dose uncertainty quantification and mitigation, which is…

Medical Physics · Physics 2021-11-17 Pia Stammer , Lucas Burigo , Oliver Jäkel , Martin Frank , Niklas Wahl

X-ray Computed Tomography (CT) is an important tool in medical imaging to obtain a direct visualization of patient anatomy. However, the x-ray radiation exposure leads to the concern of lifetime cancer risk. Low-dose CT scan can reduce the…

Medical Physics · Physics 2018-10-30 Guoyang Ma , Chenyang Shen , Xun Jia

Four-dimensional (4D) wide coverage computed tomography (CT) is an effective imaging modality for measuring the mechanical function of the myocardium. However, repeated CT measurement across several heartbeats is still a concern. A…

Medical Physics · Physics 2024-03-14 Zhye Yin , Pengwei Wu , Ashish Manohar , Elliot R. McVeigh , Jed D. Pack

Cone-beam computed tomography (CBCT) is widely used for image-guided radiotherapy (IGRT). It provides real time visualization at low cost and dose. However, photon scattering and beam hindrance cause artifacts in CBCT. These include…

Medical Physics · Physics 2025-09-29 Alzahra Altalib , Chunhui Li , Alessandro Perelli

Accurate radiotherapy dose calculation depends on converting CT Hounsfield Units (HU) to relative electron density (RED) using calibration curves. This study compared three different CT-to-RED calibration curves-two derived from physical…

Medical Physics · Physics 2025-05-12 Hossam Donya , Duong Thanh Tai , Islam G. Ali

Cloud computing allows for vast computational resources to be leveraged quickly and easily in bursts as and when required. Using the Amazon Elastic Compute Cloud and the Amazon Simple Storage Solution, we describe a technique that allows…

Medical Physics · Physics 2011-05-10 Christopher M Poole , Iwan Cornelius , Jamie V Trapp , Christian M Langton

Objective: To perform a comprehensive comparative analysis of proton, helium-ion, and carbon-ion computed tomography (CT) as direct imaging modalities for hadron therapy treatment planning, focusing on Relative Stopping Power (RSP)…

Medical Physics · Physics 2026-05-29 Zsófia Jólesz , Gábor Bíró , Gábor Papp , Gergely Gábor Barnaföldi

The effects of gold nanoparticles in 125I brachytherapy dose enhancement on choroidal Melanoma are examined using the Monte Carlo simulation technique. Usually, Monte Carlo ophthalmic brachytherapy dosimetry is performed in a water phantom.…

The Monte Carlo method is widely used in the Gamma Knife dose distribution calculations. In this study, Monte-Carlo simulation with Geant4 was applied to determine Leksell Gamma Knife dose distribution for homogeneous solid water and…

Medical Physics · Physics 2021-01-26 Ozlem Dagli , A. Gunes Tanir , Gokhan Kurt

Monte Carlo simulations are increasingly used in scintigraphic imaging to model imaging systems and to develop and assess tomographic reconstruction algorithms and correction methods for improved image quantitation. GATE (GEANT 4…

Instrumentation and Detectors · Physics 2009-11-10 D. Lazaro , I. Buvat , G. Loudos , D. Strul , G. Santin , N. Giokaris , D. Donnarieix , L. Maigne , V. Spanoudaki , S. Styliaris , S. Staelens , V. Breton

Purpose: To validate the MC-GPU Monte Carlo code for dosimetric studies in x-ray breast imaging modalities: mammography, digital breast tomosynthesis, contrast enhanced digital mammography and breast-CT. Moreover, to implement and validate…

Medical Physics · Physics 2022-04-06 Rodrigo T. Massera , Rowan M. Thomson , Alessandra Tomal

The use of GEANT4 code has increased in the medical field. There are various studies to calculate the patient dose distributions with the GEANT4 code using the imaging data. In present study, the Monte Carlo simulations based on the DICOM…

Medical Physics · Physics 2015-03-18 JeongOk Lee , JeongKu Kang , JhinKee Kim , HyeongCheol Kwon , JungSoo Kim , BuGil Kim , DongHyeok Jeong

Cone beam computed tomography (CBCT) images can be used for dose calculation in adaptive radiation therapy (ART). The main challenges are the large artefacts and inaccurate Hounsfield unit (HU) values. Currently, deformed planning CT images…

Medical Physics · Physics 2019-09-04 Xiao Liang , Liyuan Chen , Dan Nguyen , Zhiguo Zhou , Xuejun Gu , Ming Yang , Jing Wang , Steve Jiang

X-ray photon-counting computed tomography (PCCT) for extremity allows multi-energy high-resolution (HR) imaging but its radiation dose can be further improved. Despite the great potential of deep learning techniques, their application in HR…

Improving effective treatment plans in carbon ion therapy, especially for targeting radioresistant tumors located in deep seated regions while sparing normal tissues, depends on a precise and computationally efficient dose calculation…

Medical Physics · Physics 2025-06-25 Fulya Halıcılar , Metin Arık

Due to its wide field of view, cone-beam computed tomography (CBCT) is plagued by large amounts of scatter, where attenuated photons hit the detector, and corrupt the linear models used for reconstruction. Given that one can generate a good…

Medical Physics · Physics 2017-07-06 Jonathan Mason , Alessandro Perelli , William Nailon , Mike Davies

To shorten the door-to-puncture time for better treating patients with acute ischemic stroke, it is highly desired to obtain quantitative cerebral perfusion images using C-arm cone-beam computed tomography (CBCT) equipped in the…

Image and Video Processing · Electrical Eng. & Systems 2024-12-30 Haotian Zhao , Ruifeng Chen , Jing Yan , Juan Feng , Jun Xiang , Yang Chen , Dong Liang , Yinsheng Li

We propose a Noise Entangled GAN (NE-GAN) for simulating low-dose computed tomography (CT) images from a higher dose CT image. First, we present two schemes to generate a clean CT image and a noise image from the high-dose CT image. Then,…

Image and Video Processing · Electrical Eng. & Systems 2021-02-22 Chuang Niu , Ge Wang , Pingkun Yan , Juergen Hahn , Youfang Lai , Xun Jia , Arjun Krishna , Klaus Mueller , Andreu Badal , KyleJ. Myers , Rongping Zeng
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