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Agent-based models have been employed to describe numerous processes in immunology. Simulations based on these types of models have been used to enhance our understanding of immunology and disease pathology. We review various agent-based…

Cell Behavior · Quantitative Biology 2017-12-05 Amy L. Bauer , Catherine A. A. Beauchemin , Alan S. Perelson

Agent-based modeling (ABM) is a powerful computational approach for studying complex biological and biomedical systems, yet its widespread use remains limited by significant computational demands. As models become increasingly…

Quantitative Methods · Quantitative Biology 2025-04-17 Kerri-Ann Norton , Daniel Bergman , Harsh Vardhan Jain , Trachette Jackson

Computational models and simulations are not just appealing because of their intrinsic characteristics across spatiotemporal scales, scalability, and predictive power, but also because the set of problems in cancer biomedicine that can be…

Tissues and Organs · Quantitative Biology 2023-11-01 Nicolò Cogno , Cristian Axenie , Roman Bauer , Vasileios Vavourakis

The potential power provided and possibilities presented by computation graphs has steered most of the available modeling techniques to re-implementing, utilization and including the complex nature of System Biology (SB). To model the…

Multiagent Systems · Computer Science 2019-09-05 Ghazal Tashakor , Remo Suppi

HIV/AIDS spread depends upon complex patterns of interaction among various sub-sets emerging at population level. This added complexity makes it difficult to study and model AIDS and its dynamics. AIDS is therefore a natural candidate to be…

Multiagent Systems · Computer Science 2017-08-11 Amnah Siddiqa , Muaz A. Niazi

Modeling and simulation approaches for infectious disease dynamics have proven to be essential tools for effective control of the spread of epidemics in the population. Among these approaches, it is obvious that compartmental mathematical…

Populations and Evolution · Quantitative Biology 2024-11-08 Selain K. Kasereka

Understanding how an individual changes its attitude, belief, and opinion due to other people's social influences is vital because of its wide implications. A core methodology that is used to study the change of attitude under social…

Social and Information Networks · Computer Science 2023-06-07 Yun-Shiuan Chuang , Timothy T. Rogers

Cellular Agent-Based Models are commonly employed to describe a variety biological systems. Over the course of the past years, many modeling tools have emerged which solve particular research questions. In this short opinion piece, we argue…

Cell Behavior · Quantitative Biology 2025-11-18 Jonas Pleyer

Recent interest in human-AI interactions in agent-based modeling and simulation (ABMS) has grown rapidly due to the widespread utilization of large language models (LLMs). ABMS is an intelligent approach that simulates autonomous agents'…

Human-Computer Interaction · Computer Science 2025-06-18 Ziyue Lin , Siqi Shen , Zichen Cheng , Cheok Lam Lai , Siming Chen

Computational systems and methods are often being used in biological research, including the understanding of cancer and the development of treatments. Simulations of tumor growth and its response to different drugs are of particular…

Agent-based simulation (ABS) models are potent tools for analyzing complex systems. However, understanding and validating ABS models can be a significant challenge. To address this challenge, cutting-edge data-driven techniques offer…

Multiagent Systems · Computer Science 2025-07-11 Rob H. Bemthuis , Ruben R. Govers , Amin Asadi

Classical deterministic simulations of epidemiological processes, such as those based on System Dynamics, produce a single result based on a fixed set of input parameters with no variance between simulations. Input parameters are…

Computational Engineering, Finance, and Science · Computer Science 2013-07-09 Aslam Ahmed , Julie Greensmith , Uwe Aickelin

This paper presents a hybrid approach to predict the evolution of technological maturity in R and D projects, using the oil and gas sector as an example. Integrating System Dynamics (SD) and Agent Based Modelling (ABM) allows the proposed…

Multiagent Systems · Computer Science 2025-10-14 R. W. S. Pessoa , M. H. Næss , J. C. Bijos , C. M. Rebello , D. Colombo , L. Schnitman , I. B. R. Nogueira

Emergency departments (ED) face challenges in patient care and resource management. We propose to explore optimization strategies in a realistic and flexible model and develop a hybrid Discrete Event Simulation (DES) and Agent-Based Model…

Artificial Intelligence · Computer Science 2026-05-14 Markus Wenzel , Tobias Strapatsas , Jessika Kress , Dorothea Sauer , Nele Gessler , Horst K. Hahn

Modelling and computational methods have been essential in advancing quantitative science, especially in the past two decades with the availability of vast amount of complex, voluminous, and heterogeneous data. In particular, there has been…

Multiagent Systems · Computer Science 2020-07-09 Affan Shoukat , Seyed M. Moghadas

Large language models (LLMs) based Agents are increasingly pivotal in simulating and understanding complex human systems and interactions. We propose the AI-Agent School (AAS) system, built around a self-evolving mechanism that leverages…

Artificial Intelligence · Computer Science 2025-10-14 Sheng Jin , Haoming Wang , Zhiqi Gao , Yongbo Yang , Bao Chunjia , Chengliang Wang

Formal modelling of Multi-Agent Systems (MAS) is a challenging task due to high complexity, interaction, parallelism and continuous change of roles and organisation between agents. In this paper we record our research experience on formal…

Multiagent Systems · Computer Science 2010-08-20 Petros Kefalas , Ioanna Stamatopoulou

Cancer is a disease driven by random DNA mutations and the interaction of many complex phenomena. To improve the understanding and ultimately find more effective treatments, researchers leverage computer simulations mimicking the tumor…

Computational Physics · Physics 2024-01-26 Tobias Duswald , Ernesto A. B. F. Lima , J. Tinsley Oden , Barbara Wohlmuth

Agent-based models (ABMs) and video games, including those taking advantage of virtual reality (VR), have undergone a remarkable parallel evolution, achieving impressive levels of complexity and sophistication. This paper argues that while…

We apply Agent-Based Modeling and Simulation (ABMS) to investigate a set of problems in a retail context. Specifically, we are working to understand the relationship between human resource management practices and retail productivity.…

Neural and Evolutionary Computing · Computer Science 2008-12-18 Peer-Olaf Siebers , Uwe Aickelin , Helen Celia , Christopher Clegg