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In order to demonstrate acceleration of electrons to relativistic scales by an on chipdielectric laser accelerator (DLA), a ponderomotive focusing scheme capable of capturingand transporting electrons through nanometer-scale apertures over…

Accelerator Physics · Physics 2021-07-27 Alexander Ody , Sophie Crisp , Pietro Musumeci , David Cesar , R. Joel England

Counterfactual data augmentation (CDA) is a method for controlling information or biases in training datasets by generating a complementary dataset with typically opposing biases. Prior work often either relies on hand-crafted rules or…

Machine Learning · Computer Science 2025-02-26 Mitchell Plyler , Min Chi

In this letter, we study the structure-transport property relationships of small ligand intercalated DNA molecules using a multiscale modelling approach where extensive ab-initio calculations are performed on numerous MD-simulated…

DNA looping has been observed to enhance and suppress transcriptional noise but it is uncertain which of these two opposite effects is to be expected for given conditions. Here, we derive analytical expressions for the main quantifiers of…

Subcellular Processes · Quantitative Biology 2014-06-12 Jose M. G. Vilar , Leonor Saiz

DNA is increasingly employed for bio and nanotechnology thanks to its exquisite versatility and designability. Most of its use is limited to linearised and torsionally relaxed DNA but non-trivial architectures and torsionally constrained --…

Soft Condensed Matter · Physics 2020-09-22 Jan Smrek , Davide Michieletto

Composite DNA is a recent novel method to increase the information capacity of DNA-based data storage above the theoretical limit of 2 bits/symbol. In this method, every composite symbol does not store a single DNA nucleotide but a mixture…

Information Theory · Computer Science 2025-01-22 Tuan Thanh Nguyen , Chen Wang , Kui Cai , Yiwei Zhang , Zohar Yakhini

Many unsupervised domain adaptation (UDA) methods have been proposed to bridge the domain gap by utilizing domain invariant information. Most approaches have chosen depth as such information and achieved remarkable success. Despite their…

Computer Vision and Pattern Recognition · Computer Science 2022-11-17 Ting-Hsuan Liao , Huang-Ru Liao , Shan-Ya Yang , Jie-En Yao , Li-Yuan Tsao , Hsu-Shen Liu , Bo-Wun Cheng , Chen-Hao Chao , Chia-Che Chang , Yi-Chen Lo , Chun-Yi Lee

We introduce a three-state model for a single DNA chain under tension that distinguishes between B-DNA, S-DNA and M (molten or denatured) segments and at the same time correctly accounts for the entropy of molten loops, characterized by the…

Biological Physics · Physics 2015-05-18 Thomas R. Einert , Douglas B. Staple , Hans-Juergen Kreuzer , Roland R. Netz

Studies of circular DNA confined to nanofluidic channels are relevant both from a fundamental polymer-physics perspective and due to the importance of circular DNA molecules in vivo. We here observe the unfolding of DNA from the circular to…

We propose a generic model of driven DNA under the influence of an oscillatory force of amplitude $F$ and frequency $\nu$ and show the existence of a dynamical transition for a chain of finite length. We find that the area of the hysteresis…

Soft Condensed Matter · Physics 2016-03-23 Sanjay Kumar , Ravinder Kumar , Wolfhard Janke

Because of the limitations of classical silicon based computational technology, several alternatives to traditional method in form of unconventional computing have been proposed. In this paper we will focus on DNA computing which is showing…

Biomolecules · Quantitative Biology 2017-03-31 Mandrita Mondal , Kumar S. Ray

Mechanical properties of DNA, in particular their stretch dependent extension and their loop formation characteristics, have been recognized as an effective probe for understanding the possible biochemical role played by them in a living…

Soft Condensed Matter · Physics 2015-06-04 Kulveer Singh , Surya K. Ghosh , Sanjay Kumar , Anirban Sain

For many decades, advances in static verification have focused on linear integer arithmetic (LIA) programs. Many real-world programs are, however, written with non-linear integer arithmetic (NLA) expressions, such as programs that model…

Programming Languages · Computer Science 2023-06-28 Yuandong Cyrus Liu , Ton-Chanh Le , Timos Antonopoulos , Eric Koskinen , ThanhVu Nguyen

Existing large language models (LLMs) that mainly focus on Standard American English (SAE) often lead to significantly worse performance when being applied to other English dialects. While existing mitigations tackle discrepancies for…

Computation and Language · Computer Science 2023-12-07 Yanchen Liu , William Held , Diyi Yang

Cells regulate fates and complex body plans using spatiotemporal signaling cascades that alter gene expression. Enhancers, short DNA sequences (50-150 base pairs), help coordinate these cascades by attracting regulatory proteins to enhance…

Molecular Networks · Quantitative Biology 2024-02-15 Lucas Hedström , Ralf Metzler , Ludvig Lizana

A common approach to quantifying DNA involves repeated cycles of DNA amplification. This approach, employed by the polymerase chain reaction (PCR), produces outputs that are corrupted by amplification noise, making it challenging to…

Quantitative Methods · Quantitative Biology 2023-01-06 Abdoelnaser M Degoot , Wilfred Ndifon

Constrained Horn Clauses (CHCs) are often used in automated program verification. Thus, techniques for (dis-)proving satisfiability of CHCs are a very active field of research. On the other hand, acceleration techniques for computing…

Logic in Computer Science · Computer Science 2023-07-17 Florian Frohn , Jürgen Giesl

We have developed a generalized semi-analytic approach for efficiently computing cyclization and looping $J$ factors of DNA under arbitrary binding constraints. Many biological systems involving DNA-protein interactions impose precise…

Biomolecules · Quantitative Biology 2015-05-14 David P. Wilson , Alexei V. Tkachenko , Jens-Christian Meiners

Formal transformations somehow resembling the usual derivative are surprisingly common in computer science, with two notable examples being derivatives of regular expressions and derivatives of types. A newcomer to this list is the…

Programming Languages · Computer Science 2016-11-11 Robert Kelly , Barak A. Pearlmutter , Jeffrey Mark Siskind

Many unsupervised domain adaptation (UDA) methods exploit domain adversarial training to align the features to reduce domain gap, where a feature extractor is trained to fool a domain discriminator in order to have aligned feature…

Computer Vision and Pattern Recognition · Computer Science 2021-08-10 Xin Jin , Cuiling Lan , Wenjun Zeng , Zhibo Chen