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Gene products (RNAs, proteins) often occur at low molecular counts inside individual cells, and hence are subject to considerable random fluctuations (noise) in copy number over time. Not surprisingly, cells encode diverse regulatory…

Molecular Networks · Quantitative Biology 2015-10-01 Thierry Platini , Mohammad Soltani , Abhyudai Singh

The influence of multiple vibrational modes on current fluctuations in electron transport through single-molecule junctions is investigated. Our analysis is based on a generic model of a molecular junction, which comprises a single…

Mesoscale and Nanoscale Physics · Physics 2014-09-26 C. Schinabeck , R. Härtle , H. B. Weber , M. Thoss

Using a stochastic individual-based modelling approach, we examine the role that Delta-Notch signalling plays in the regulation of a robust and reliable somite segmentation clock. We find that not only can Delta-Notch signalling synchronise…

Subcellular Processes · Quantitative Biology 2019-11-28 Joseph W. Baron , Tobias Galla

Stochastic resonance is a non-linear phenomenon, in which the sensitivity of signal detectors can be enhanced by adding random noise to the detector input. Here, we demonstrate that noise can also improve the information flux in recurrent…

Neurons and Cognition · Quantitative Biology 2018-11-30 Patrick Krauss , Karin Prebeck , Achim Schilling , Claus Metzner

The creation and subsequent evolution of marginally-unstable modes have been observed in a wide range of fusion devices. This behaviour has been successfully explained, for a single frequency shifting mode, in terms of phase-space…

We analyze theoretically and experimentally the influence of current noise on the longitudinal mode hopping dynamics of a bulk semiconductor laser. It is shown that the mean residence times on each mode have different sensitivity to…

Optics · Physics 2009-11-11 F. Pedaci , S. Lepri , S. Balle , G. Giacomelli , M. Giudici , J. R. Tredicce

This paper investigates the impact of control field noise on the optimal manipulation of quantum dynamics. Simulations are performed on several multilevel quantum systems with the goal of population transfer in the presence of significant…

Chemical Physics · Physics 2009-11-11 Feng Shuang , Herschel Rabitz

We show a noise-induced transition in Josephson junction with fundamental as well as second harmonic. A periodically modulated multiplicative colored noise can stabilize an unstable configuration in such a system. The stabilization of the…

Superconductivity · Physics 2018-03-06 Nivedita Bhadra

Consider a dynamical system given by a planar differential equation, which exhibits an unstable periodic orbit surrounding a stable periodic orbit. It is known that under random perturbations, the distribution of locations where the…

Probability · Mathematics 2014-01-20 Nils Berglund , Barbara Gentz

We study the impact of noise on a neural population rate model of up and down states. Up and down states are typically observed in neuronal networks as a slow oscillation, where the population switches between high and low firing rates…

Neurons and Cognition · Quantitative Biology 2015-04-24 Zachary McCleney , Zachary P. Kilpatrick

Expression of many genes varies as a cell transitions through different cell-cycle stages. How coupling between stochastic expression and cell cycle impacts cell-to-cell variability (noise) in the level of protein is not well understood. We…

Molecular Networks · Quantitative Biology 2016-05-10 Mohammad Soltani , Abhyudai Singh

We present a study investigating the role of mitochondrial variability in generating noise in eukaryotic cells. Noise in cellular physiology plays an important role in many fundamental cellular processes, including transcription,…

Cell Behavior · Quantitative Biology 2015-05-28 Iain G. Johnston , Bernadett Gaal , Ricardo Pires das Neves , Tariq Enver , Francisco J. Iborra , Nick S. Jones

Gene expression and its regulation is a nonequilibrium stochastic process. Different molecules are involved in several biochemical steps in this process with low copies. It is observed that the stochasticity in biochemical processes is…

Molecular Networks · Quantitative Biology 2019-05-22 Rajesh Karmakar

Stochastic resonance is a counter-intuitive concept[1,2], ; the addition of noise to a noisy system induces coherent amplification of its response. First suggested as a mechanism for the cyclic recurrence of ice ages, stochastic resonance…

Mesoscale and Nanoscale Physics · Physics 2009-11-11 R. L. Badzey , P. Mohanty

Vector fields that are discontinuous on codimension-one surfaces are known as Filippov systems and can have attracting periodic orbits involving segments that are contained on a discontinuity surface of the vector field. In this paper we…

Dynamical Systems · Mathematics 2015-05-20 David J. W. Simpson , Rachel Kuske

Engineering biology requires precise control of biomolecular circuits, and Cybergenetics is the field dedicated to achieving this goal. A significant challenge in developing controllers for cellular functions is designing systems that can…

Quantitative Methods · Quantitative Biology 2024-09-18 Hamza Faquir , Manuel Pájaro , Irene Otero-Muras

Fluctuations and noise may alter the behavior of dynamical systems considerably. For example, oscillations may be sustained by demographic fluctuations in biological systems where a stable fixed point is found in the absence of noise. We…

Adaptation and Self-Organizing Systems · Physics 2009-11-13 Richard P. Boland , Tobias Galla , Alan J. McKane

We demonstrate that waves in distinct layers of a neuronal network can become phase-locked by common spatiotemporal noise. This phenomenon is studied for stationary bumps, traveling waves, and breathers. A weak noise expansion is used to…

Pattern Formation and Solitons · Physics 2015-04-22 Zachary P. Kilpatrick

The activity generated by an ensemble of neurons is affected by various noise sources. It is a well-recognised challenge to understand the effects of noise on the stability of such networks. We demonstrate that the patterns of activity…

Analysis of PDEs · Mathematics 2022-05-19 Jose A. Carrillo , Helge Holden , Susanne Solem

Due to inherent noise in intracellular networks cellular decisions can be random, so genetically identical cells can display different phenotypic behavior even in identical environments. Most previous work in understanding the…

Molecular Networks · Quantitative Biology 2015-06-15 Michael Assaf , Elijah Roberts , Zaida Luthey-Schulten , Nigel Goldenfeld
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