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Specific protein-protein interactions are crucial in the cell, both to ensure the formation and stability of multi-protein complexes, and to enable signal transduction in various pathways. Functional interactions between proteins result in…

Biological Physics · Physics 2016-11-21 Anne-Florence Bitbol , Robert S. Dwyer , Lucy J. Colwell , Ned S. Wingreen

Large Language Models (LLMs) have shown promise in assisting scientific discovery. However, such applications are currently limited by LLMs' deficiencies in understanding intricate scientific concepts, deriving symbolic equations, and…

Computation and Language · Computer Science 2024-11-19 Dan Zhang , Ziniu Hu , Sining Zhoubian , Zhengxiao Du , Kaiyu Yang , Zihan Wang , Yisong Yue , Yuxiao Dong , Jie Tang

Efficiently selecting relevant content from vast candidate pools is a critical challenge in modern recommender systems. Traditional methods, such as item-to-item collaborative filtering (CF) and two-tower models, often fall short in…

Information Retrieval · Computer Science 2026-01-26 Shaoqing Wang , Yingcai Ma , Kairui Fu , Ziyang Wang , Dunxian Huang , Yuliang Yan , Jian Wu

In recent years, the research community has raised serious questions about the reproducibility of scientific work. In particular, since many studies include some kind of computing work, reproducibility is also a technological challenge, not…

Software Engineering · Computer Science 2023-08-03 Lázaro Costa , Susana Barbosa , Jácome Cunha

E-commerce search systems rely on modeling user behavior to estimate item relevance and user preference, which are typically assumed to be stable and independently learnable signals. However, in practice, user interactions are jointly…

Information Retrieval · Computer Science 2026-05-11 Haoqian Zhang , Ziyuan Yang , Yi Zhang

In this paper we reproduce experimental results presented in our earlier work titled "Describing Subjective Experiment Consistency by $p$-Value P-P Plot" that was presented in the course of the 28th ACM International Conference on…

Multimedia · Computer Science 2022-09-02 Jakub Nawała , Lucjan Janowski , Bogdan Ćmiel , Krzysztof Rusek , Marc A. Kastner , Jan Zahálka

Study reproducibility is essential to corroborate, build on, and learn from the results of scientific research but is notoriously challenging in bioinformatics, which often involves large data sets and complex analytic workflows involving…

Quantitative Methods · Quantitative Biology 2023-05-22 Christopher R. Keefe , Matthew R. Dillon , Chloe Herman , Mary Jewell , Colin V. Wood , Evan Bolyen , J. Gregory Caporaso

Relational type systems have been designed for several applications including information flow, differential privacy, and cost analysis. In order to achieve the best results, these systems often use relational refinements and relational…

Programming Languages · Computer Science 2020-11-18 Ezgi Çiçek , Weihao Qu , Gilles Barthe , Marco Gaboardi , Deepak Garg

A recent study showed that more than 70% of researchers fail to reproduce their peers's experiments and more than half fail to reproduce their own experiments. Obviously, from a perspective of scientific quality this is a more than…

Human-Computer Interaction · Computer Science 2021-03-18 Andrew Tristan , Vinicius Woloszyn , Ben Kaden

Supervised fine-tuning of large language models relies on human-annotated data, yet annotation pipelines routinely involve multiple crowdworkers of heterogeneous expertise. Standard practice aggregates labels via majority vote or simple…

Machine Learning · Computer Science 2026-04-21 Sajjad Ghiasvand , Mark Beliaev , Mahnoosh Alizadeh , Ramtin Pedarsani

Motivation: Drug discovery demands rapid quantification of compound-protein interaction (CPI). However, there is a lack of methods that can predict compound-protein affinity from sequences alone with high applicability, accuracy, and…

Biomolecules · Quantitative Biology 2020-12-17 Mostafa Karimi , Di Wu , Zhangyang Wang , Yang Shen

Protein interaction networks (PIN) are popular means to visualize the proteome. However, PIN datasets are known to be noisy, incomplete and biased by the experimental protocols used to detect protein interactions. This paper aims at…

Disordered Systems and Neural Networks · Physics 2015-01-06 Alessia Annibale , Anthony C. C. Coolen , Nuria Planell-Morell

Finding interactions between variables in large and high-dimensional datasets is often a serious computational challenge. Most approaches build up interaction sets incrementally, adding variables in a greedy fashion. The drawback is that…

Machine Learning · Statistics 2016-04-27 Rajen Dinesh Shah , Nicolai Meinshausen

Conversational recommender systems (CRS) that are able to interact with users in natural language often utilize recommendation dialogs which were previously collected with the help of paired humans, where one plays the role of a seeker and…

Computation and Language · Computer Science 2022-09-08 Ahtsham Manzoor , Dietmar Jannach

Code comment generation aims to generate high-quality comments from source code automatically and has been studied for years. Recent studies proposed to integrate information retrieval techniques with neural generation models to tackle this…

Software Engineering · Computer Science 2024-08-08 Hanzhen Lu , Zhongxin Liu

Scientific peer reviews frequently contain conflicting expert judgments, and the increasing scale of conference submissions makes it challenging for Area Chairs and editors to reliably identify and interpret such disagreements. Existing…

Computation and Language · Computer Science 2026-05-12 Sandeep Kumar , Yash Kamdar , Abid Hossain , Bharti Kumari , Tanik Saikh , Asif Ekbal

How and where proteins interface with one another can ultimately impact the proteins' functions along with a range of other biological processes. As such, precise computational methods for protein interface prediction (PIP) come highly…

Quantitative Methods · Quantitative Biology 2021-10-08 Alex Morehead , Chen Chen , Ada Sedova , Jianlin Cheng

Software libraries for most of the modern programming languages are numerous, large and complex. Remembering the syntax and usage of APIs is a difficult task for not just novices but also expert programmers. IDEs (Integrated Development…

Human-Computer Interaction · Computer Science 2014-09-24 Anant Bhardwaj , Dave Luciano , Scott Klemmer

Most of the state-of-the-art semantic segmentation reported in recent years is based on fully supervised deep learning in the medical domain. How?ever, the high-quality annotated datasets require intense labor and domain knowledge,…

Image and Video Processing · Electrical Eng. & Systems 2022-04-25 Pingping Dai , Haiming Zhu , Shuang Ge , Ruihan Zhang , Xiang Qian , Xi Li , Kehong Yuan

We explain the methodology we developed for improving the interactions accomplished by an embedded conversational agent, drawing from Conversation Analytic sequential and multimodal analysis. The use case is a Pepper robot that is expected…

Artificial Intelligence · Computer Science 2023-08-30 Lucien Tisserand , Frédéric Armetta , Heike Baldauf-Quilliatre , Antoine Bouquin , Salima Hassas , Mathieu Lefort
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