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We consider the translocation dynamics of a polymer chain forced through a nanopore by an external force on its head monomer on the trans side. For a proper theoretical treatment we generalize the iso-flux tension propagation (IFTP) theory…

Soft Condensed Matter · Physics 2018-02-14 Jalal Sarabadani , Bappa Ghosh , Srabanti Chaudhury , Tapio Ala-Nissila

The motion of polymers with inhomogeneous structure through nanopores is discussed theoretically. Specifically, we consider the translocation dynamics of polymers consisting of double-stranded and single-stranded blocks. Since only the…

Statistical Mechanics · Physics 2009-11-11 Stanislav Kotsev , Anatoly B. Kolomeisky

We study the translocation dynamics of a polymer chain threaded through a nanopore by an external force. By means of diverse methods (scaling arguments, fractional calculus and Monte Carlo simulation) we show that the relevant dynamic…

Statistical Mechanics · Physics 2007-07-29 J. L. A. Dubbeldam , A. Milchev , V. G. Rostiashvili , T. A. Vilgis

Polymer translocation in crowded environments is a ubiquitous phenomenon in biological systems. We studied polymer translocation through a pore in free, one-sided (asymmetric), and two-sided (symmetric) crowded environments. Extensive…

Soft Condensed Matter · Physics 2024-03-01 Vrinda Garg , Rejoy Mathew , Riyan Ibrahim , Kulveer Singh , Surya K. Ghosh

In forced polymer translocation, the average translocation time, $\tau$, scales with respect to pore force, $f$, and polymer length, $N$, as $\tau \sim f^{-1} N^{\beta}$. We demonstrate that an artifact in Metropolis Monte Carlo method…

Biological Physics · Physics 2009-11-13 V. V. Lehtola , R. P. Linna , K. Kaski

In this paper, we investigate the microscopic dynamics of a polymer of length $N$ translocating through a narrow pore. Characterization of its purportedly anomalous dynamics has so far remained incomplete. We show that the polymer dynamics…

Soft Condensed Matter · Physics 2007-07-25 Debabrata Panja , Gerard T. Barkema , Robin C. Ball

We consider a polymer of length $N$ translocating through a narrow pore in the absence of external fields. Characterization of its purportedly anomalous dynamics has so far remained incomplete. We show that the polymer dynamics is anomalous…

Soft Condensed Matter · Physics 2007-10-08 Debabrata Panja , Gerard T. Barkema , Robin C. Ball

We investigate the influence of varying confinement on the dynamics of polymer translocation through a cone shaped channel. For this, a linear polymer chain is modeled by a self voiding walks (SAWs) on a square lattice. The cis-side of a…

Soft Condensed Matter · Physics 2024-01-10 Manish Dwivedi , Sumitra Rudra , Sanjay Kumar

We study the translocation process of a polymer in the absence of external fields for various pore diameters $b$ and membrane thickness $L$. The polymer performs Rouse and reptation dynamics. The mean translocation time $<\tau_t>$ that the…

Soft Condensed Matter · Physics 2007-05-23 Joanne Klein Wolterink , Gerard T. Barkema , Debabrata Panja

We develop a theory for polymer translocation driven by a time-dependent force through an oscillating nanopore. To this end, we extend the iso-flux tension propagation theory (IFTP) [Sarabadani \textit{et al., J. Chem. Phys.}, 2014,…

Statistical Mechanics · Physics 2015-09-02 Jalal Sarabadani , Timo Ikonen , Tapio Ala-Nissila

Motivated by experiments in which a polynucleotide is driven through a proteinaceous pore by an electric field, we study the diffusive motion of a polymer threaded through a narrow channel with which it may have strong interactions. We show…

Biological Physics · Physics 2009-10-31 David K. Lubensky , David R. Nelson

Brownian dynamics (BD) simulations are used to study the translocation dynamics of a coarse-grained polymer through a cylindrical nanopore. We consider the case of short polymers, with a polymer length, N, in the range N=21-61. The rate of…

Soft Condensed Matter · Physics 2015-06-18 James M. Polson , Taylor Dunn

The transport of biomolecules across a cell membrane is an important phenomena that plays a pivotal role in the functioning of biological cells. In this paper, we investigate such processes by modeling the translocation of polymers through…

Soft Condensed Matter · Physics 2022-11-01 Andri Sharma

We investigate the translocation dynamics of a folded linear polymer which is pulled through a nanopore by an external force. To this end, we generalize the iso-flux tension propagation (IFTP) theory for end-pulled polymer translocation to…

Soft Condensed Matter · Physics 2019-12-18 Bappa Ghosh , Jalal Sarabadani , Srabanti Chaudhury , Tapio Ala-Nissila

We investigate the influence of polymer-pore interactions on the translocation dynamics using Langevin dynamics simulations. An attractive interaction can greatly improve translocation probability. At the same time, it also increases…

Soft Condensed Matter · Physics 2007-10-01 Kaifu Luo , Tapio Ala-Nissila , See-chen Ying , Aniket Bhattacharya

We investigate the problem of polymer translocation through a nanopore in the absence of an external driving force. To this end, we use the two-dimensional (2D) fluctuating bond model with single-segment Monte Carlo moves. To overcome the…

Computational Physics · Physics 2012-12-06 Kaifu Luo , Tapio Ala-Nissila , See-chen Ying

We use a combination of computer simulations and iso-flux tension propagation (IFTP) theory to investigate translocation dynamics of a flexible linear polymer through a nanopore into an environment composed of repulsive active rods in 2D.…

Soft Condensed Matter · Physics 2021-02-03 Hamidreza Khalilian , Jalal Sarabadani , Tapio Ala-Nissila

Polymer translocation has long been a topic of interest in the field of biological physics given its relevance in both biological (protein and DNA/RNA translocation through nuclear and cell membranes) and technological processes (nanopore…

Soft Condensed Matter · Physics 2023-09-11 Alejandro Sainz-Agost , Fernando Falo , Alessandro Fiasconaro

We investigate the process of biopolymer translocation through a narrow pore using a multiscale approach which explicitly accounts for the hydrodynamic interactions of the molecule with the surrounding solvent. The simulations confirm that…

Biological Physics · Physics 2009-01-16 Maria Fyta , Simone Melchionna , Sauro Succi , Efthimios Kaxiras

In this work we study the noise induced effects on the dynamics of short polymers crossing a potential barrier, in the presence of a metastable state. An improved version of the Rouse model for a flexible polymer has been adopted to mimic…

Statistical Mechanics · Physics 2009-11-13 N. Pizzolato , A. Fiasconaro , B. Spagnolo