Related papers: Scientific and Technological Development of Hadron…
We recently introduced a completely new way to study ultrarelativistic nuclear scattering by providing a link between the string model approach and a statistical description. A key issue is the microcanonical treatment of hadronizing…
Boron Neutron Capture Therapy (BNCT) is an innovative binary form of radiation therapy with high selectivity towards cancer tissue based on the neutron capture reaction 10B(n,$\alpha$)7Li, consisting in the exposition of patients to neutron…
Muon tomography is a technique that uses cosmic ray muons to generate three dimensional images of volumes using information contained in the Coulomb scattering of the muons. Advantages of this technique are the ability of cosmic rays to…
High Power Target systems are key elements in future neutrino and other rare particle production in accelerators. These systems transform an intense source of protons into secondary particles of interest to enable new scientific…
We propose a multi-scale approach to understanding physics related to the ion/proton-beam cancer therapy and calculation of the probability of the DNA damage as a result of irradiation of patients with energetic (up to 430 MeV/u) ions. This…
Laser-driven ion acceleration is an attractive technique for compact high-energy ion sources. Currently, among various physical and technical issues to be solved, the boost of ion energy and the reduction of energy spread represent the key…
Accurate control and monitoring of the beam is essential for precise dose delivery to tumor tissues during radiotherapy. Real-time monitoring of ion beam profiles and positions improves beam control, patient safety, and treatment…
Proton radiography is a new scatheless diagnostic tool, and which provides a potential development direction for advanced hydrotesting. Recently a low energy proton radiography system has been developed at CAEP. This system has been…
Uncertainties in the proton range in tissue during proton therapy limit the precision in treatment delivery. These uncertainties result in expanded treatment margins, thereby increasing radiation dose to healthy tissue. Real-time range…
This Habilitationsschrift (Habilitation thesis) is focused on my research activities on medical applications of particle physics and was written in 2013 to obtain the Venia Docendi (Habilitation) in experimental physics at the University of…
Ultraperipheral collisions at collider energies are a useful tool to study photon-hadron (proton/nucleus) and photon-photon interactions in a hitherto unexplored energy regime. Theoretical tools to study these processes are briefly…
We propose an innovative method for proton radiography based on nuclear emulsion film detectors, a technique in which images are obtained by measuring the position and the residual range of protons passing through the patient's body. For…
In carbon-therapy, the interaction of the incoming beam with human tissues may lead to the production of a large amount of nuclear fragments and secondary light particles. An accurate estimation of the biological dose deposited into the…
We employ a multi-scale mechanistic approach to investigate radiation induced cell toxicities and deactivation mechanisms as a function of linear energy transfer in hadron therapy. Our theoretical model consists of a system of Markov chains…
Fast procedures for the beam quality assessment and for the monitoring of beam energy modulations during the irradiation are among the most urgent improvements in particle therapy. Indeed, the online measurement of the particle beam energy…
We clarify how intense laser irradiation leads to an enhancement of rare processes that may occur within atoms. Non-perturbative calculation using a coherent laser beam gives an exact, time dependent formula of the enhancement factor in the…
Proton therapy is a modality in fast development. Characterized by a maximum dose deposition at the end of the proton trajectory followed by a sharp fall-off, proton beams can deliver a highly conformal dose to the tumor while sparing…
Atomic nuclei can be used as spatial analyzers of the hadronization process in semi-inclusive deep inelastic scattering. The study of this process using fully-identified final state hadrons began with the HERMES program in the late 1990s,…
Recently, experiments have been reported where researchers were able to perform high dynamic range (HDR) tomography in a heuristic fashion, by fusing multiple tomographic projections. This approach to HDR tomography has been inspired by HDR…
Background and purpose: Accelerator-Based Boron Neutron Capture Therapy is a radiotherapy based on compact accelerator neutron sources requiring an epithermal neutron field for tumour irradiations. Neutrons of 10 keV are considered as the…