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Stochastic gene expression has been implicated in a variety of cellular processes, including cell differentiation and disease. In this issue of Cell, Weinberger et al. (2005) take an integrated computational-experimental approach to study…

Molecular Networks · Quantitative Biology 2007-05-23 Leor S. Weinberger , John C. Burnett , Jared E. Toettcher , Adam P. Arkin , David V. Schaffer

Chronic viral infections can persist in an infected person for decades. From the perspective of the virus, a single infection can span thousands of generations, leading to a highly diverse population of viruses with its own complex…

Populations and Evolution · Quantitative Biology 2023-05-30 Dmitry Gromov , Ethan O. Romero-Severson

The stacked contact process is a stochastic model for the spread of an infection within a population of hosts located on the $d$-dimensional integer lattice. Regardless of whether they are healthy or infected, hosts give birth and die at…

Probability · Mathematics 2014-10-16 Nicolas Lanchier , Yuan Zhang

Cross-sectional incidence estimation based on recency testing has become a widely used tool in HIV research. Recently, this method has gained prominence in HIV prevention trials to estimate the "placebo" incidence that participants might…

Methodology · Statistics 2024-12-18 Jianan Pan , Marlena Bannick , Fei Gao

In this study, we investigate the dynamics of a spatial and non spatial prey-predator interaction model that includes the following: (i) fear effect incorporated in prey birth rate; (ii) group defence of prey against predators; and (iii)…

Populations and Evolution · Quantitative Biology 2023-11-07 Shivam Yadav , Jai Prakash Tripathi , Shrichand Bhuria , Satish Kumar Tiwari , Deepak Tripathi , Vandana Tiwari , Ranjit Kumar Upadhyay , Yun Kang

This paper investigates the long-term dynamics of a reaction-diffusion predator-prey system subject to random environmental fluctuations modeled by Markovian switching. The model is formulated as a hybrid system of partial differential…

Analysis of PDEs · Mathematics 2025-07-10 Nguyen H. Du , Nhu N. Nguyen

Respondent-driven sampling is a form of link-tracing network sampling, which is widely used to study hard-to-reach populations, often to estimate population proportions. Previous treatments of this process have used a with-replacement…

Methodology · Statistics 2010-06-25 Krista J. Gile

Dynamic models have been successfully used in producing estimates of HIV epidemics at national level, due to their epidemiological nature and their ability to simultaneously estimate prevalence, incidence, and mortality rates. Recently, HIV…

Methodology · Statistics 2016-02-19 Le Bao , Ben Sheng , Xiaoyue Niu , Yuan Tang , Tim Brown , Peter D. Ghys , Jeff W. Eaton

During primary HIV infection, the kinetics of plasma virus concentrations and CD4+ cell counts is very complex. Parametric and nonparametric models have been suggested for fitting repeated measurements of these markers. Alternatively,…

Applications · Statistics 2011-01-07 J. Drylewicz , J. Guedj , D. Commenges , R. Thiébaut

Mutational escape from vaccine induced immune responses has thwarted the development of a successful vaccine against AIDS, whose causative agent is HIV, a highly mutable virus. Knowing the virus' fitness as a function of its proteomic…

Mathematical modeling based on time-delay differential equations is an important tool to study the role of delay in biological systems and to evaluate its impact on the asymptotic behavior of their dynamics. Delays are indeed found in many…

Dynamical Systems · Mathematics 2022-03-25 Abdelmalik Moujahid , Fernando Vadillo

We consider a spatial stochastic model for a pathogen population growing inside a host that attempts to eliminate the pathogens through its immune system. The pathogen population is divided into different types. A pathogen can either…

Probability · Mathematics 2026-02-03 Fábio Lopes , Alejandro Roldán-Correa

Stochastic, spatially extended models for predator-prey interaction display spatio-temporal structures that are not captured by the Lotka-Volterra mean-field rate equations. These spreading activity fronts reflect persistent correlations…

Statistical Mechanics · Physics 2024-05-09 Uwe C. Täuber

Random mixing in host populations has been a convenient simplifying assumption in the study of epidemics, but neglects important differences in contact rates within and between population groups. For HIV/AIDS, the assumption of random…

Quantitative Methods · Quantitative Biology 2016-02-24 Brian G. Williams , Christopher Dye

In this paper, we propose a mathematical model for HIV-1 infection with intracellular delay. The model examines a viral-therapy for controlling infections through recombining HIV-1 virus with a genetically modified virus. For this model,…

Dynamical Systems · Mathematics 2014-04-10 Yun Tian , Yu Bai , Pei Yu

Intraspecific trait variation has been increasingly recognized as an important factor in determining species interaction and diversity. Eco-evolutionary models have studied the distribution of trait values within a population that changes…

Populations and Evolution · Quantitative Biology 2023-10-12 Zachary Jackson , BingKan Xue

Antagonistic coevolution between hosts and parasites can have a major impact on host population structures, and hence on the evolution of social traits. Using stochastic modelling techniques in the context of bacteria-virus interactions, we…

Populations and Evolution · Quantitative Biology 2012-10-09 Benjamin J. Z. Quigley , Diana García López , Angus Buckling , Alan J. McKane , Sam P. Brown

Recently, a long-term model of HIV infection dynamics was developed to describe the entire time course of the disease. It consists of a large system of ODEs with many parameters, and is expensive to simulate. In the current paper, this…

Populations and Evolution · Quantitative Biology 2016-04-20 Tyson Loudon , Stephen Pankavich

Drug resistance remains a major problem for the treatment of HIV. Resistance can occur due to mutations that were present before treatment starts or due to mutations that occur during treatment. The relative importance of these two sources…

Populations and Evolution · Quantitative Biology 2015-06-03 Pleuni S. Pennings

Groups in ecology are often affected by sudden environmental perturbations. Parameters of stochastic models are often imprecise due to various uncertainties. In this paper, we formulate a stochastic Holling II one-predator two-prey system…

Probability · Mathematics 2020-06-29 Fei Sun
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