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In people infected with HIV the RNA viral load is a good predictor of the rate of loss of CD4 cells at a population level but there is still great variability in the rate of decline of CD4 cells among individuals. Here we show that the…

Cell Behavior · Quantitative Biology 2009-08-12 Brian G. Williams , Eline L. Korenromp , Eleanor Gouws , Christopher Dye

The host immune response can often efficiently suppress a virus infection, which may lead to selection for immune-resistant viral variants within the host. For example, during HIV infection, an array of CTL immune response populations…

Populations and Evolution · Quantitative Biology 2018-02-23 Cameron J. Browne , Hal L. Smith

The evolution and emergence of antibiotic resistance is a major public health concern. The understanding of the within-host microbial dynamics combining mutational processes, horizontal gene transfer and resource consumption, is one of the…

Populations and Evolution · Quantitative Biology 2020-03-09 Ramsès Djidjou-Demasse , Samuel Alizon , Mircea T. Sofonea

This chapter gives a synopsis of recent approaches to model and analyse the evolution of microbial populations under selection. The first part reviews two population genetic models of Lenski's long-term evolution experiment with Escherichia…

Populations and Evolution · Quantitative Biology 2021-06-30 Ellen Baake , Anton Wakolbinger

In this paper, the mathematical model of HIV infection for CD8+ T-cells is illustrated. The homotopy analysis method and the Laplace transformations are combined for solving this model. Also, the convergence theorem is proved to demonstrate…

Computational Engineering, Finance, and Science · Computer Science 2019-07-03 Samad Noeiaghdam , Emran Khoshrouye Ghiasi

We propose a hybrid dynamical system approach to model the evolution of a pathogen that experiences different selective pressures according to a stochastic process. In every environment, the evolution of the pathogen is described by a…

Classical Analysis and ODEs · Mathematics 2019-03-25 Jozsef Z. Farkas , Peter Hinow , Jan Engelstädter

In this article we suggest a new statistical approach considering survival heterogeneity as a breakpoint model in an ordered sequence of time to event variables. The survival responses need to be ordered according to a numerical covariate.…

Applications · Statistics 2016-09-26 Olivier Bouaziz , Grégory Nuel

We consider a Human Immunodeficiency Virus (HIV) model with a logistic growth term and continue the analysis of the previous article [6]. We now take the viral diffusion in a two-dimensional environment. The model consists of two ODEs for…

Analysis of PDEs · Mathematics 2012-11-02 Claude-Michel Brauner , Xinyue Fan , Luca Lorenzi

A discrete chemotactic predator-prey model is proposed in which the prey secrets a diffusing chemical which is sensed by the predator and vice versa. Two dynamical states corresponding to catching and escaping are identified and it is shown…

Populations and Evolution · Quantitative Biology 2015-05-20 Ankush Sengupta , Tobias Kruppa , Hartmut Löwen

Horizontal gene Transfer (HT) denotes the transmission of genetic material between two living organisms, while the vertical transmission refers to a DNA transfer from parents to their offspring. Consistent experimental evidence report that…

Populations and Evolution · Quantitative Biology 2021-02-12 Vincent Calvez , Susely Figueroa Iglesias , Hélène Hivert , Sylvie Méléard , Anna Melnykova , Samuel Nordmann

We study how the interplay between the memory immune response and pathogen mutation affects epidemic dynamics in two related models. The first explicitly models pathogen mutation and individual memory immune responses, with contacted…

Chaotic Dynamics · Physics 2009-11-07 Michelle Girvan , Duncan S. Callaway , M. E. J. Newman , Steven H. Strogatz

In this paper we study a model of HCV with mitotic proliferation, a saturation infection rate and a discrete intracellular delay: the delay corresponds to the time between infection of a infected target hepatocytes and production of new HCV…

Dynamical Systems · Mathematics 2014-03-13 E. Avila-Vales , N. Chan-Chí , G. García-Almeida , C. Vargas-De-León

We propose a time-parameterized analogy between the thermodynamic behavior of a 3-level energy system and the progression of the HIV infection described by the cell population evolution generated by an appropriated cellular automata model.…

Populations and Evolution · Quantitative Biology 2020-06-24 Ramón E. R. González , P. H. Figueirêdo , S. Coutinho

The rise of antimicrobial drug resistance is an imminent threat to global health that has warranted, and duly received, considerable attention within the medical, microbiological and modelling communities. Outbreaks of drug-resistant…

Populations and Evolution · Quantitative Biology 2019-07-12 Michael T. Meehan , Robert C. Cope , Emma S. McBryde

The occurrence of discrimination is an important problem in the social and economical sciences. Much of the discrimination observed in empirical studies can be explained by the theory of in-group favoritism, which states that people tend to…

Physics and Society · Physics 2019-03-15 Gorm Gruner Jensen , Stefan Bornholdt

In this paper, we proposed a population model depicting the dynamics of a prey species showing group defence against a generalist predator. The group defence characteristic is represented by a non-monotonic functional response. We have…

Dynamical Systems · Mathematics 2022-09-09 R. R. Patra , S. Maitra , S. Kundu

Vector-borne diseases often infect multiple host species, increasing the likelihood of disease persistence due to the presence of multiple reservoirs. Vector biting patterns and feeding preferences can shift in response to selective…

Populations and Evolution · Quantitative Biology 2026-05-01 Shravani Shetgaonkar , Anupama Sharma

Background: High HIV transmission persists in many U.S. jurisdictions despite prevention efforts. HIV self-testing offers a means to overcome barriers associated with routine laboratory-based testing but carries a risk of increasing…

Dynamical Systems · Mathematics 2025-04-23 Alex Viguerie

Spatially extended population dynamics models that incorporate intrinsic noise serve as case studies for the role of fluctuations and correlations in biological systems. Including spatial structure and stochastic noise in predator-prey…

Statistical Mechanics · Physics 2018-01-09 Ulrich Dobramysl , Mauro Mobilia , Michel Pleimling , Uwe C. Täuber

The population dynamics of predator-prey systems in the presence of patch-specific predators are explored in a setting where the prey population has access to both habitats. The emphasis is in situations where patch-prey abundance drives…

Dynamical Systems · Mathematics 2009-07-31 F. Berezovskaya , S. Wirkus , C. Castillo-Chavez
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