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Oncolytic virotherapy, utilizing genetically modified viruses to combat cancer and trigger anti-cancer immune responses, has garnered significant attention in recent years. In our previous work arXiv:2305.12386, we developed a stochastic…

Populations and Evolution · Quantitative Biology 2026-04-23 David Morselli , Marcello E. Delitala , Adrianne L. Jenner , Federico Frascoli

HIV dynamical models are often based on non-linear systems of ordinary differential equations (ODE), which do not have analytical solution. Introducing random effects in such models leads to very challenging non-linear mixed-effects models.…

Statistics Theory · Mathematics 2010-02-03 D. Commenges , D. Jolly , H. Putter , R. Thiebaut

A delayed model describing the dynamics of HIV (Human Immunodeficiency Virus) with CTL (Cytotoxic T Lymphocytes) immune response is investigated. The model includes four nonlinear differential equations describing the evolution of…

Optimization and Control · Mathematics 2018-06-13 Karam Allali , Sanaa Harroudi , Delfim F. M. Torres

We consider a spatially-heterogeneous generalization of a well-established model for the dynamics of the Human Immunodeficiency Virus-type 1 (HIV) within a susceptible host. The model consists of a nonlinear system of three coupled…

Analysis of PDEs · Mathematics 2016-04-18 Stephen Pankavich , Christian Parkinson

We propose a population model for HIV-TB co-infection dynamics by considering treatments for HIV infection, active tuberculosis and co-infection. The HIV only and TB only models are analyzed separately, as well as full model. The basic…

Populations and Evolution · Quantitative Biology 2018-08-10 Sachin Kumar , Shikha Jain

This paper introduces an innovative model for infectious diseases in predator-prey populations. We not only prove the existence of global non-negative solutions but also establish essential criteria for the system's decline and…

Populations and Evolution · Quantitative Biology 2023-06-16 Yujie Gao , Malay Banerjee , Ton Viet Ta

The "Kill the Winner" hypothesis is an attempt to address the problem of diversity in biology. It argues that host-specific predators control the population of each prey, preventing a winner from emerging and thus maintaining the…

Biological Physics · Physics 2018-01-03 Chi Xue , Nigel Goldenfeld

In this paper we explore the eco-evolutionary dynamics of a predator-prey model, where the prey population is structured according to a certain life history trait. The trait distribution within the prey population is the result of interplay…

Populations and Evolution · Quantitative Biology 2019-03-27 József Z. Farkas , A. Yu. Morozov

We are interested in modeling some two-level population dynamics, resulting from the interplay of ecological interactions and phenotypic variation of individuals (or hosts) and the evolution of cells (or parasites) of two types living in…

Probability · Mathematics 2011-01-21 Sylvie Méléard , Sylvie Roelly

A stochastic epidemic model accounting for the effect of contact-tracing on the spread of an infectious disease is studied. Precisely, individuals identified as infected may contribute to detecting other infectious individuals by providing…

Probability · Mathematics 2009-03-28 Stéphan Clémençon , Viet Chi Tran , Hector De Arazoza

Recently, [8] has proposed that heterogeneity of infectiousness (and susceptibility) across individuals in infectious diseases, plays a major role in affecting the Herd Immunity Threshold (HIT). Such heterogeneity has been observed in…

Populations and Evolution · Quantitative Biology 2024-12-18 Jhonatan Tavori , Hanoch Levy

A non-Markovian stochastic predator-prey model is introduced in which the prey are immobile plants and predators are diffusing herbivors. The model is studied by both mean-field approximation (MFA)and computer simulations. The MFA results a…

Disordered Systems and Neural Networks · Physics 2009-10-31 Rouzbeh Gerami , Mohammad R. Ejtehadi

We consider a simple deterministic model which describes an asymmetric competition between an immune system with a specific and powerful response, and a virus with a broad toxicity and fast mutations. Interest in this model relies on the…

Quantitative Methods · Quantitative Biology 2011-01-17 Thierry Gobron , Mario Santoro , Livio Triolo

In this paper, we construct a model to describe the transmission of HIV in a homogeneous host population. By considering the specific mechanism of HIV, we derive a model structured in three successive stages: (i) primary infection, (ii)…

Analysis of PDEs · Mathematics 2019-11-18 Mboya Ba , Ramsès Djidjou-Demasse , Mountaga Lam , Jean-Jules Tewa

Ending the HIV/AIDS pandemic is among the Sustainable Development Goals for the next decade. In order to overcome the gap between the need for care and the available resources, better understanding of HIV epidemics is needed to guide policy…

Applications · Statistics 2020-09-03 Zhou Lan , Le Bao

We study within-host HIV dynamics using a three--component nonlinear ordinary differential equation model for healthy CD4$^{+}$ T cells, infected CD4$^{+}$ T cells, and free virus. In addition to the baseline model without treatment, we…

Numerical Analysis · Mathematics 2025-12-16 Abdul Rab

We make a mathematical analysis of an age structured HIV infection model with both virus-to-cell and cell-to-cell transmissions to understand the dynamical behavior of HIV infection in vivo. In the model, we consider the proliferation of…

Populations and Evolution · Quantitative Biology 2018-09-26 Xiangming Zhang , Zhihua Liu

An investigation was conducted to study the robustness of the results obtained from the cellular automata model which describes the spread of the HIV infection within lymphoid tissues [R. M. Zorzenon dos Santos and S. Coutinho, Phys. Rev.…

Biological Physics · Physics 2008-07-21 P. H. Figueirêdo , S. Coutinho , R. M. Zorzenon dos Santos

This contribution is devoted to a new model of HIV multiplication motivated by the patent of one of the authors. We take into account the antigenic diversity through what we define "antigenicity", whether of the virus or of the adapted…

Numerical Analysis · Mathematics 2011-02-02 François Dubois , Hervé Le Meur , Claude Reiss

We introduce and analyze a within-host dynamical model of the coevolution between rapidly mutating pathogens and the adaptive immune response. Pathogen mutation and a homeostatic constraint on lymphocytes both play a role in allowing the…

Populations and Evolution · Quantitative Biology 2014-08-06 Kimberly J. Schlesinger , Sean P. Stromberg , Jean M. Carlson