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Cluster analysis of biological samples using gene expression measurements is a common task which aids the discovery of heterogeneous biological sub-populations having distinct mRNA profiles. Several model-based clustering algorithms have…

Methodology · Statistics 2012-01-30 Alberto Cozzini , Ajay Jasra , Giovanni Montana

With the rapid advances of microarray technologies, large amounts of high-dimensional gene expression data are being generated, which poses significant computational challenges. A first step towards addressing this challenge is the use of…

Computer Vision and Pattern Recognition · Computer Science 2013-02-14 P. K. Nizar Banu , H. Hannah Inbarani

The discovery of disease subtypes is an essential step for developing precision medicine, and disease subtyping via omics data has become a popular approach. While promising, subtypes obtained from conventional approaches may not be…

Applications · Statistics 2023-09-28 Lingsong Meng , Zhiguang Huo

Notwithstanding the popularity of conventional clustering algorithms such as K-means and probabilistic clustering, their clustering results are sensitive to the presence of outliers in the data. Even a few outliers can compromise the…

Machine Learning · Statistics 2015-05-27 Pedro A. Forero , Vassilis Kekatos , Georgios B. Giannakis

Clustering is a popular data mining technique that aims to partition an input space into multiple homogeneous regions. There exist several clustering algorithms in the literature. The performance of a clustering algorithm depends on its…

Human-Computer Interaction · Computer Science 2020-08-20 Sudip Poddar , Anirban Mukhopadhyay

Clustering analysis is one of the most widely used statistical tools in many emerging areas such as microarray data analysis. For microarray and other high-dimensional data, the presence of many noise variables may mask underlying…

Machine Learning · Statistics 2008-03-26 Benhuai Xie , Wei Pan , Xiaotong Shen

High-throughput microarray and sequencing technology have been used to identify disease subtypes that could not be observed otherwise by using clinical variables alone. The classical unsupervised clustering strategy concerns primarily the…

Methodology · Statistics 2020-07-23 Peng Liu , Yusi Fang , Zhao Ren , Lu Tang , George C. Tseng

Sequential pattern mining (SPM) has excellent prospects and application spaces and has been widely used in different fields. The non-overlapping SPM, as one of the data mining techniques, has been used to discover patterns that have…

Databases · Computer Science 2023-04-25 Zefeng Chen , Wensheng Gan , Gengsen Huang , Yan Li , Zhenlian Qi

Many important real-world applications involve time-series data with skewed distribution. Compared to conventional imbalance learning problems, the classification of imbalanced time-series data is more challenging due to high dimensionality…

Machine Learning · Computer Science 2022-04-19 Tuanfei Zhu , Cheng Luo , Jing Li , Siqi Ren , Zhihong Zhang

Discrete mixture models provide a well-known basis for effective clustering algorithms, although technical challenges have limited their scope. In the context of gene-expression data analysis, a model is presented that mixes over a finite…

Methodology · Statistics 2012-11-12 Michael A. Newton , Lisa M. Chung

Subspace clustering refers to the task of finding a multi-subspace representation that best fits a collection of points taken from a high-dimensional space. This paper introduces an algorithm inspired by sparse subspace clustering (SSC) [In…

Machine Learning · Computer Science 2014-05-26 Mahdi Soltanolkotabi , Ehsan Elhamifar , Emmanuel J. Candès

Generating interpretable visualizations from complex data is a common problem in many applications. Two key ingredients for tackling this issue are clustering and representation learning. However, current methods do not yet successfully…

Machine Learning · Computer Science 2020-06-11 Laura Manduchi , Matthias Hüser , Julia Vogt , Gunnar Rätsch , Vincent Fortuin

Rapid technological advances have allowed for molecular profiling across multiple omics domains from a single sample for clinical decision making in many diseases, especially cancer. As tumor development and progression are dynamic…

Methodology · Statistics 2022-02-11 Dongyan Yan , Subharup Guha

Kernel matrices (e.g. Gram or similarity matrices) are essential for many state-of-the-art approaches to classification, clustering, and dimensionality reduction. For large datasets, the cost of forming and factoring such kernel matrices…

Machine Learning · Statistics 2015-05-21 Raajen Patel , Thomas A. Goldstein , Eva L. Dyer , Azalia Mirhoseini , Richard G. Baraniuk

The K-means algorithm is among the most commonly used data clustering methods. However, the regular K-means can only be applied in the input space and it is applicable when clusters are linearly separable. The kernel K-means, which extends…

Machine Learning · Computer Science 2020-12-08 Amir Aradnia , Maryam Amir Haeri , Mohammad Mehdi Ebadzadeh

Clustering data is a popular feature in the field of unsupervised machine learning. Most algorithms aim to find the best method to extract consistent clusters of data, but very few of them intend to cluster data that share the same…

Machine Learning · Computer Science 2022-06-22 Jean-Sébastien Dessureault , Daniel Massicotte

Clustering is a popular form of unsupervised learning for geometric data. Unfortunately, many clustering algorithms lead to cluster assignments that are hard to explain, partially because they depend on all the features of the data in a…

Machine Learning · Computer Science 2020-09-23 Sanjoy Dasgupta , Nave Frost , Michal Moshkovitz , Cyrus Rashtchian

Simulation-based inference (SBI) has become an important tool in cosmology for extracting additional information from observational data using simulations. However, all cosmological simulations are approximations of the actual universe, and…

Cosmology and Nongalactic Astrophysics · Physics 2025-07-08 Sébastien Pierre , Bruno Régaldo-Saint Blancard , ChangHoon Hahn , Michael Eickenberg

Microarray techniques are widely used in Gene expression analysis. These techniques are based on discovering submatrices of genes that share similar expression patterns across a set of experimental conditions with coherence constraint.…

Quantitative Methods · Quantitative Biology 2020-01-27 Bilal Taher , Muhammad. H Fares , Saeed Jalili

Most current sampling algorithms for high-dimensional distributions are based on MCMC techniques and are approximate in the sense that they are valid only asymptotically. Rejection sampling, on the other hand, produces valid samples, but is…

Artificial Intelligence · Computer Science 2012-07-04 Marc Dymetman , Guillaume Bouchard , Simon Carter