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Constraints in embryonic development are thought to bias the direction of evolution by making some changes less likely, and others more likely, depending on their consequences on ontogeny. Here, we characterize the constraints acting on…
Feature-based visual structure and motion reconstruction pipelines, common in visual odometry and large-scale reconstruction from photos, use the location of corresponding features in different images to determine the 3D structure of the…
The influence of the microstructural geometry on the behavior of porous media is widely recognized, particularly in geomaterials, but also in biomaterials and engineered materials. Recent advances in imaging techniques, such as X-ray…
We propose a two-scale model to resolve essential features of developmental tissue deformations. The model couples individual cellular behavior to the mechanics at tissue scale. This is realized by a multiphase-field model addressing the…
Biological systems can form complex three-dimensional structures through the collective behavior of agents that share a common update rule and operate without central control. How such distributed control gives rise to precise global…
Morphogenesis emerges from dynamic feedback among geometry, mechanics, and chemistry; however, disentangling these contributions in living systems remains challenging. Here, we focus on the interplay between geometry and mechanics by…
Accurate representations of 3D faces are of paramount importance in various computer vision and graphics applications. However, the challenges persist due to the limitations imposed by data discretization and model linearity, which hinder…
A curious feature of organ and organoid morphogenesis is that in certain cases, spatial oscillations in the thickness of the growing "film" are out-of-phase with the deformation of the slower-growing "substrate," while in other cases, the…
Embryonic development is driven by spatial patterns of gene expression that determine the fate of each cell in the embryo. While gene expression is often highly erratic, embryonic development is usually exceedingly precise. In particular,…
We show that the boundary curves (profiles) in $\R^2$ of the generalized projections of a body in $\R^3$ uniquely determine a large class of shapes, and that sparse profile data, combined with projection volume (brightness) data, can be…
Human motion generation has been widely studied due to its crucial role in areas such as digital humans and humanoid robot control. However, many current motion generation approaches disregard physics constraints, frequently resulting in…
Structural defects within amorphous packings of symmetric particles can be characterized using a machine learning approach that incorporates structure functions of radial distances and angular arrangement. This yields a scalar field,…
Morphogenesis, the establishment and repair of emergent complex anatomy by groups of cells, is a fascinating and biomedically-relevant problem. One of its most fascinating aspects is that a developing embryo can reliably recover from…
MicroRNAs are endogenous non-coding RNAs which negatively regulate the expression of protein-coding genes in plants and animals. They are known to play an important role in several biological processes and, together with transcription…
There are many cases in collider physics and elsewhere where a calibration dataset is used to predict the known physics and / or noise of a target region of phase space. This calibration dataset usually cannot be used out-of-the-box but…
The asymptotic shape of randomly growing radial clusters is studied. We pose the problem in terms of the dynamics of stochastic partial differential equations. We concentrate on the properties of the realizations of the stochastic growth…
Evolutionary search is well suited for large-scale biophysical brain modeling, where many parameters with nonlinear interactions and no tractable gradients need to be optimized. Standard evolutionary approaches achieve an excellent fit to…
Most biological systems are formed by component parts that to some degree are inter-related. Groups of parts that are more associated among themselves and are relatively autonomous from others are called modules. One of the consequences of…
Evolution sculpts both the body plans and nervous systems of agents together over time. In contrast, in AI and robotics, a robot's body plan is usually designed by hand, and control policies are then optimized for that fixed design. The…
The concept of fitness as a measure for a species's success in natural selection is central to the theory of evolution. We here investigate how reproduction rates which are not constant but vary in response to environmental fluctuations,…