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Life events can dramatically affect our psychological state and work performance. Stress, for example, has been linked to professional dissatisfaction, increased anxiety, and workplace burnout. We explore the impact of positive and negative…
Modifications of signaling pathways and synapses owing to changing behaviors, environments, numerous neural modulation as well as brain-tissue injuries is defined as neuroplasticity in developmental neurology. The central purpose of the…
The sensory contact model allows forming different psychopathological states (anxious depression, catalepsy, social withdrawal, pathological aggression, hypersensitivity, cognition disturbances, anhedonia, alcoholism etc.) produced by…
Most disorders are caused by a combination of multiple genetic and/or environmental factors. If two diseases are caused by the same molecular mechanism, they tend to co-occur in patients. Here we provide a quantitative method to disentangle…
Background: Stress and negative affect play significant roles in developing psychosis. Bayesian analyses applied to the conditioned hallucinations (CH) task suggest that hallucinations arise when maladaptive prior beliefs outweigh sensory…
Adverse drug events (ADEs) are unexpected incidents caused by the administration of a drug or medication. To identify and extract these events, we require information about not just the drug itself but attributes describing the drug (e.g.,…
Opioid and substance misuse is rampant in the United States today, with the phenomenon known as the "opioid crisis". The relationship between substance use and mental health has been extensively studied, with one possible relationship…
Premature birth and various pre- and peri-natal stresses can lead to a variety of brain lesions and have clearly been identified as major risk factors for neurodevelopmental disorders, with variable but multiple consequences that can…
This paper presents a complete theory of autism spectrum disorder (ASD), explaining its etiology, symptoms, and pathology. The core cause of ASD is excessive stress-induced postnatal release of corticotropin-releasing hormone (CRH). CRH…
Lyrics play a crucial role in affecting and reinforcing emotional states by providing meaning and emotional connotations that interact with the acoustic properties of the music. Specific lyrical themes and emotions may intensify existing…
Migraine (MGR) ranks first among diseases in terms of years of lost healthy life in young adult and adult women. Currently, there is no theory of MGR. This paper presents a complete theory of migraine that explains its etiology, symptoms,…
We propose that dACC, AI and caudolateral OFC(clOFC) project to lateral habenula (LHb) and D2 loop of ventral striatum (VS), forming a functional adversity processing circuit, directed towards inhibitory avoidance and self-control. This…
The textbook picture of nerve activity is that of a propagating voltage pulse driven by electrical currents through ion channel proteins, which are gated by changes in voltage, temperature, pressure or by drugs. All function is directly…
Estimating emotional states from physiological signals is a central topic in affective computing and psychophysiology. While many emotion estimation systems implicitly assume a stable relationship between physiological features and…
Locomotor system disorders affect a vast majority of people at some time in their life bringing pain, functional limitations, social and economic implications. Modern medicine cannot offer prevention and effective treatment for most chronic…
LLM agents are increasingly used for social simulation, yet emotion is often treated as a transient cue, causing emotional amnesia and weak long-horizon continuity. We present Sentipolis, a framework for emotionally stateful agents that…
The dependence of two-level systems in disordered atomic chain on pressure, both positive and negative was studied numerically. The disorder was produced through the use of interatomic pair potentials having more than one energy minimum. It…
Opioid and substance misuse is rampant in the United States today, with the phenomenon known as the opioid crisis. The relationship between substance use and mental health has been extensively studied, with one possible relationship being…
Substances of abuse are known to activate and disrupt neuronal circuits in the brain reward system. We propose a simple and easily interpretable dynamical systems model to describe the neurobiology of drug addiction that incorporates the…
We reveal the intricate impact of nonlinearity and disorder on the thermal conductivity of acoustic chains. Disorder induces mobility edges and allows to control the amount of extended modes which are the ballistic channels for energy…