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Entropy is critically examined as a fundamental concept in contemporary science and informatics. Although the typical Shannon entropy provides a proper framework for describing the canonical ensemble, it fails to represent adequately the…

Statistical Mechanics · Physics 2026-02-23 Roumen Tsekov

Autonomous systems with cognitive features are on their way into the market. Within complex environments, they promise to implement complex and goal oriented behavior even in a safety related context. This behavior is based on a certain…

Artificial Intelligence · Computer Science 2020-02-20 Henrik J. Putzer , Ernest Wozniak

Language models are revolutionizing the biochemistry domain, assisting scientists in drug design and chemical synthesis with high efficiency. Yet current approaches struggle between small language models prone to hallucination and limited…

Machine Learning · Computer Science 2026-02-02 Hao Li , He Cao , Shenyao Peng , Zijing Liu , Bin Feng , Yu Wang , Zhiyuan Yan , Yonghong Tian , Yu Li , Li Yuan

The advent of advanced AI underscores the urgent need for comprehensive safety evaluations, necessitating collaboration across communities (i.e., AI, software engineering, and governance). However, divergent practices and terminologies…

Software Engineering · Computer Science 2024-05-17 Boming Xia , Qinghua Lu , Liming Zhu , Zhenchang Xing

The seemingly infinite diversity of the natural world arises from a relatively small set of coherent rules, such as the laws of physics or chemistry. We conjecture that these rules give rise to regularities that can be discovered through…

First principles based exploration of chemical space deepens our understanding of chemistry, and might help with the design of new materials or experiments. Due to the computational cost of quantum chemistry methods and the immens number of…

Chemical Physics · Physics 2020-08-18 Bing Huang , O. Anatole von Lilienfeld

In silico design of new molecules and materials with desirable quantum properties by high-throughput screening is a major challenge due to the high dimensionality of chemical space. To facilitate its navigation, we present a unification of…

Chemical Physics · Physics 2018-10-02 Stijn Fias , K. Y. Samuel Chang , O. Anatole von Lilienfeld

The chemistry of an astrophysical environment is closely coupled to its dynamics, the latter often found to be complex. Hence, to properly model these environments a 3D context is necessary. However, solving chemical kinetics within a 3D…

Computational Physics · Physics 2024-05-07 S. Maes , F. De Ceuster , M. Van de Sande , L. Decin

Over the past decade, Artificial Intelligence has significantly advanced, mostly driven by large-scale neural approaches. However, in the chemical process industry, where safety is critical, these methods are often unsuitable due to their…

Machine Learning · Computer Science 2026-03-24 Julien Amblard , Niklas Groll , Matthew Tait , Mark Law , Gürkan Sin , Alessandra Russo

Machine learning techniques are now routinely encountered in research laboratories across the globe. Impressive progress has been made through ML and AI techniques with regards to large data set processing. This progress has increased the…

Machine Learning · Computer Science 2026-02-27 Ilya Balabin , Thomas M. Kaiser

The recently emerged molecular communication (MC) paradigm intends to leverage communication engineering tools for the design of synthetic chemical communication systems. These systems are envisioned to operate at nanoscale and in…

Information Theory · Computer Science 2024-04-05 Lukas Brand , Yan Wang , Maurizio Magarini , Robert Schober , Sebastian Lotter

Deep learning algorithms have recently gained significant attention due to their impressive performance. However, their high complexity and un-interpretable mode of operation hinders their confident deployment in real-world safety-critical…

Machine Learning · Computer Science 2024-06-28 Konstantinos P. Panousis , Dino Ienco , Diego Marcos

Autoformalization has emerged as a term referring to the automation of formalization - specifically, the formalization of mathematics using interactive theorem provers (proof assistants). Its rapid development has been driven by progress in…

Artificial Intelligence · Computer Science 2025-12-16 Agnieszka Mensfelt , David Tena Cucala , Santiago Franco , Angeliki Koutsoukou-Argyraki , Vince Trencsenyi , Kostas Stathis

Research on algorithms has drastically increased in recent years. Various sub-disciplines of computer science investigate algorithms according to different objectives and standards. This plurality of the field has led to various…

Data Structures and Algorithms · Computer Science 2025-09-17 Jan Mendling , Henrik Leopold , Henning Meyerhenke , Benoît Depaire

We report a method to convert discrete representations of molecules to and from a multidimensional continuous representation. This model allows us to generate new molecules for efficient exploration and optimization through open-ended…

An image related question defines a specific visual task that is required in order to produce an appropriate answer. The answer may depend on a minor detail in the image and require complex reasoning and use of prior knowledge. When humans…

Computer Vision and Pattern Recognition · Computer Science 2018-10-26 Ben Zion Vatashsky , Shimon Ullman

Creating autonomous, self-supporting, self-replicating, sustainable systems is a great challenge. To some extent, understanding life means not only being able to create it from scratch, but also improving, supporting, saving it, or even…

Robotics · Computer Science 2011-11-07 Serge Kernbach

Contemporary neural networks still fall short of human-level generalization, which extends far beyond our direct experiences. In this paper, we argue that the underlying cause for this shortcoming is their inability to dynamically and…

Neural and Evolutionary Computing · Computer Science 2020-12-10 Klaus Greff , Sjoerd van Steenkiste , Jürgen Schmidhuber

Formal Concept Analysis (FCA) is a mathematical framework for knowledge representation and discovery. It performs a hierarchical clustering over a set of objects described by attributes, resulting in conceptual structures in which objects…

Artificial Intelligence · Computer Science 2025-08-12 Jessie Galasso

A flexible treatment for gas- and aerosol-phase chemical processes has been developed for models of diverse scale, from box models up to global models. At the core of this novel framework is an "abstracted aerosol representation" that…

Computational Engineering, Finance, and Science · Computer Science 2021-11-16 Matthew L. Dawson , Christian Guzman , Jeffrey H. Curtis , Mario Acosta , Shupeng Zhu , Donald Dabdub , Andrew Conley , Matthew West , Nicole Riemer , Oriol Jorba
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