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Percutaneous catheter pumps are intraventricular temporary mechanical circulatory support (MCS) devices that are positioned across the aortic valve into the left ventricle (LV) and provide continuous antegrade blood flow from the LV into…

Medical Physics · Physics 2023-12-11 Greg W. Burgreen , Mansur Zhussupbekov , Rodrigo Méndez Rojano , James F. Antaki

Rapid identification of microparticles in liquid is an important problem in environmental and biomedical applications such as for microplastic detection in water sources and physiological fluids. Existing spectro-scopic techniques are…

Applied Physics · Physics 2024-11-20 Yagmur Ceren Alatas , Uzay Tefek , Sayedus Salehin , Hashim Alhmoud , M. Selim Hanay

Magnetic flux distribution across a high-temperature superconductor strip is measured using magneto-optical imaging at 15 K. Both the current-carrying state and the remanent state after transport current are studied up to the currents 0.97…

The transport and manipulation of particles and cells in microfluidic devices has become a core methodology in domains ranging from molecular biology to manufacturing and drug design. The rational design and operation of such devices can…

Computational Engineering, Finance, and Science · Computer Science 2020-07-15 Dmitry Alexeev , Lucas Amoudruz , Sergey Litvinov , Petros Koumoutsakos

We study deformability-based sorting of same-size RBCs via DLD using an in-house integral equation solver. Our goal is to quantitatively characterize the physical mechanisms that enable the cell separation. To this end, we systematically…

Computational Physics · Physics 2018-11-30 Gokberk Kabacaoglu , George Biros

Droplet-based microfluidic systems are a promising platform forlab-on-a-chip (LoC) applications. These systems can also be used toenhance LoC applications with integrated droplet control information or for data transmission scenarios in the…

Emerging Technologies · Computer Science 2021-01-12 Max Bartunik , Marco Fleischer , Werner Haselmayr , Jens Kirchner

An important step in diagnostics is the isolation of specific cells and microorganisms of interest from blood. Since such bioparticles are often present at very low concentrations, throughput needs to be as high as possible. In addition, to…

Soft Condensed Matter · Physics 2019-07-31 Stefan H. Holm , Zunmin Zhang , Jason P. Beech , Gerhard Gompper , Dmitry A. Fedosov , Jonas O. Tegenfeldt

The frictional forces of a viscous liquid flow are a major energy loss issue and severely limit microfluidics practical use. Reducing this drag by more than a few tens of percent remain illusive. Here, we show how cylindrical…

Applied Physics · Physics 2021-10-04 Arvind Arun Dev , Peter Dunne , Thomas M. Hermans , Bernard Doudin

Blood vessel constriction is simulated with particle-based method using a molecular dynamics authoring software known as Molecular Workbench (WM). Blood flow and vessel wall, the only components considered in constructing a blood vessel,…

Biological Physics · Physics 2014-04-01 Mohamad Rendi , Suprijadi , Sparisoma Viridi

We consider the motion of red blood cells and other non-spherical microcapsules dilutely suspended in a simple shear flow. Our analysis indicates that depending on the viscosity, membrane elasticity, geometry and shear rate, the particle…

Soft Condensed Matter · Physics 2015-06-25 J. M. Skotheim , T. W. Secomb

Ensemble averaging experiments may conceal many fundamental molecular interactions. To overcome that, a high-throughput detection of single molecules or colloidal nanodots is crucial for biomedical, nanoelectronic, and solid-state…

Biological Physics · Physics 2019-07-15 Siddharth Ghosh , Narain Karedla , Ingo Gregor

We exploit magnetostriction in polydisperse ferrofluids in order to generate nonlinear responses, and apply a thermodynamical method to derive the desired nonlinear magnetic susceptibility. For an ideal gas, this method has been…

Soft Condensed Matter · Physics 2009-11-10 J. P. Huang , C. Holm

In this paper the bright-field defocusing microscopy (DM) technique is presented. DM is able to obtain quantitative information of each plane/surface of pure phase objects, as live unlabeled cells, and its application to red blood cells…

Biological Physics · Physics 2014-12-01 L. Siman , P. M. S. Roma , F. T. Amaral , U. Agero , O. N. Mesquita

Flowing blood displays a phenomenon called margination, in which leukocytes and platelets are preferentially found near blood vessel walls, while erythrocytes are depleted from these regions. Here margination is investigated using direct…

Soft Condensed Matter · Physics 2012-09-05 Amit Kumar , Michael D. Graham

A fluid mechanics problem is solved which technological prototype is a fluid acoustic contact that is an inherent element of ultrasonic non-destructive testing procedures. It is well known that the acoustic contact established with an…

Fluid Dynamics · Physics 2026-03-19 Denis S. Goldobin , Yuriy L. Raikher

Flux vortices in superconductors can be imaged using transmission electron microscopy because the electron beam is deflected by the magnetic flux associated with the vortices. This technique has a better spatial and temporal resolution than…

Superconductivity · Physics 2009-10-31 J. C. Loudon , P. A. Midgley

Monodisperse lipid-coated microbubbles are a promising route to unlock the full potential of ultrasound contrast agents for medical diagnosis and therapy. Here, we present a stand-alone lab-on-a-chip instrument that allows microbubbles to…

Standing-wave excitation of fluorescence is highly desirable in optical microscopy because it improves the axial resolution. We demonstrate here that multiplanar excitation of fluorescence by a standing wave can be produced in a single-spot…

Biological Physics · Physics 2015-01-05 Rumelo Amor , Sumeet Mahajan , William Bradshaw Amos , Gail McConnell

The transport of Brownian particles in a slit geometry in the presence of an arbitrary two-dimensional periodic energy landscape and driven by an external force or convected by a flow field is investigated by means of macrotransport theory.…

Statistical Mechanics · Physics 2012-10-16 Jorge A. Bernate , German Drazer

We have developed a microfluidic tool to measure the diffusion coefficient $D$ of solutes in an aqueous solution, by following the temporal relaxation of an initially steep concentration gradient in a microchannel. Our chip exploits…

Soft Condensed Matter · Physics 2022-08-23 Hoang-Thanh Nguyen , Anne Bouchaudy , Jean-Baptiste Salmon