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Splicing systems are generative mechanisms introduced by Tom Head in 1987 to model the biological process of DNA recombination. The computational engine of a splicing system is the "splicing operation", a cut-and-paste binary string…

Formal Languages and Automata Theory · Computer Science 2019-09-06 Lila Kari , Timothy Ng

A splicing system is a formal model of a recombinant behaviour of sets of double stranded DNA molecules when acted on by restriction enzymes and ligase. In this survey we will concentrate on a specific behaviour of a type of splicing…

Formal Languages and Automata Theory · Computer Science 2015-10-07 Luc Boasson , Paola Bonizzoni , Clelia De Felice , Isabelle Fagnot , Gabriele Fici , Rocco Zaccagnino , Rosalba Zizza

The string splicing was introduced by Tom Head which stands as an abstract model for the DNA recombination under the influence of restriction enzymes. The complex chemical process of three dimensional molecules in three dimensional space…

Discrete Mathematics · Computer Science 2007-05-23 L. Jeganathan , R. Rama

This paper outlines an application of iterated version of generalised sequential crossover of two languages (which in some sense, an abstraction of the crossover of chromosomes in living organisms) in studying some classes of the newly…

Discrete Mathematics · Computer Science 2009-02-24 L. Jeganathan , R. Rama , Ritabrata Sengupta

Splicing as a binary word/language operation is inspired by the DNA recombination under the action of restriction enzymes and ligases, and was first introduced by Tom Head in 1987. Shortly thereafter, it was proven that the languages…

Formal Languages and Automata Theory · Computer Science 2012-08-31 Lila Kari , Steffen Kopecki

Gene assembly is an intricate biological process that has been studied formally and modeled through string and graph rewriting systems. Recently, a restriction of the general (intramolecular) model, called simple gene assembly, has been…

Logic in Computer Science · Computer Science 2007-12-21 Robert Brijder , Hendrik Jan Hoogeboom

We propose that genetic encoding of self-assembling components greatly enhances the evolution of complex systems and provides an efficient platform for inductive generalization, i.e. the inductive derivation of a solution to a problem with…

Populations and Evolution · Quantitative Biology 2007-05-23 Rudolf M. Fuechslin , Thomas Maeke , Uwe Tangen , John S. McCaskill

The biological process of gene assembly has been modeled based on three types of string rewriting rules, called string pointer rules, defined on so-called legal strings. It has been shown that reduction graphs, graphs that are based on the…

Logic in Computer Science · Computer Science 2008-11-24 Robert Brijder , Hendrik Jan Hoogeboom

DNA self-assembly is an important tool that has a wide range of applications such as building nanostructures, the transport of target virotherapies, and nano-circuitry. Tools from graph theory can be used to encode the biological process of…

Combinatorics · Mathematics 2023-10-09 Cory Johnson , Andrew Lavengood-Ryan

This paper introduces a new family of reconstruction codes which is motivated by applications in DNA data storage and sequencing. In such applications, DNA strands are sequenced by reading some subset of their substrings. While previous…

Information Theory · Computer Science 2023-04-21 Yonatan Yehezkeally , Daniella Bar-Lev , Sagi Marcovich , Eitan Yaakobi

Compositional generalization is one of the main properties which differentiates lexical learning in humans from state-of-art neural networks. We propose a general framework for building models that can generalize compositionally using the…

Computation and Language · Computer Science 2024-02-05 Mircea Petrache , Shubhendu Trivedi

Amidst all candidates of physics beyond the Standard Model, string theory provides a unique proposal for incorporating gauge and gravitational interactions. In string theory, a four-dimensional theory that unifies quantum mechanics and…

High Energy Physics - Theory · Physics 2024-09-30 Fernando Marchesano , Gary Shiu , Timo Weigand

We present an analytically solvable model for self-assembly of a molecular complex on a filament. The process is driven by a seed molecule that undergoes facilitated diffusion, which is a search strategy that combines diffusion in…

Statistical Mechanics · Physics 2015-11-04 Ziya Kalay

The problem of RNA secondary structure design (also called inverse folding) is the following: given a target secondary structure, one aims to create a sequence that folds into, or is compatible with, a given structure. In several practical…

Quantitative Methods · Quantitative Biology 2013-08-02 Yu Zhou , Yann Ponty , Stéphane Vialette , Jérôme Waldispühl , Yi Zhang , Alain Denise

Motivation: Alternative splicing is an important mechanism in which the regions of pre-mRNAs are differentially joined in order to form different transcript isoforms. Alternative splicing is involved in the regulation of normal…

Quantitative Methods · Quantitative Biology 2016-05-26 Hande Topa , Antti Honkela

In this paper we present a model containing modifications to the Signal-passing Tile Assembly Model (STAM), a tile-based self-assembly model whose tiles are capable of activating and deactivating glues based on the binding of other glues.…

Emerging Technologies · Computer Science 2022-03-30 Andrew Alseth , Daniel Hader , Matthew J. Patitz

Composite function minimization captures a wide spectrum of applications in both computer vision and machine learning. It includes bound constrained optimization, $\ell_1$ norm regularized optimization, and $\ell_0$ norm regularized…

Numerical Analysis · Computer Science 2018-06-11 Ganzhao Yuan , Wei-Shi Zheng , Li Shen , Bernard Ghanem

We study DNA self-assembly and DNA computation using a coarse-grained DNA model within the directional dynamic bonding framework {[}C. Svaneborg, Comp. Phys. Comm. 183, 1793 (2012){]}. In our model, a single nucleotide or domain is…

Soft Condensed Matter · Physics 2012-06-13 Carsten Svaneborg , Harold Fellermann , Steen Rasmussen

The Watson-Crick complementary properties of DNA make DNA a useful tool for the self-assembly of various target complexes. Concepts from graph theory can be used to model the self-assembling process in which the vertices of the graph…

Combinatorics · Mathematics 2023-02-28 Gabriel Lopez , Cory Johnson

We calculate the partition function of the $SU(N)$ ( and $U(N)$) generalized $YM_2$ theory defined on an arbitrary Riemann surface. The result which is expressed as a sum over irreducible representations generalizes the Rusakov formula for…

High Energy Physics - Theory · Physics 2009-10-28 O. Ganor , J. Sonnenschein , S. Yankielowicz
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