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Deciphering the function of unseen protein sequences is a fundamental challenge with broad scientific impact, yet most existing methods depend on task-specific adapters or large-scale supervised fine-tuning. We introduce the…

Machine Learning · Computer Science 2025-10-14 Xinhui Chen , Zuchao Li , Mengqi Gao , Yufeng Zhang , Chak Tou Leong , Haoyang Li , Jiaqi Chen

Polymer literature contains a large and growing body of experimental knowledge, yet much of it is buried in unstructured text and inconsistent terminology, making systematic retrieval and reasoning difficult. Existing tools typically…

Computational Engineering, Finance, and Science · Computer Science 2026-02-19 Sonakshi Gupta , Akhlak Mahmood , Wei Xiong , Rampi Ramprasad

Molecule and text representation learning has gained increasing interest due to its potential for enhancing the understanding of chemical information. However, existing models often struggle to capture subtle differences between molecules…

Machine Learning · Computer Science 2025-10-31 Hyuntae Park , Yeachan Kim , SangKeun Lee

While text mining and NLP research has been established for decades, there remain gaps in the literature that reports the use of these techniques in building real-world applications. For example, they typically look at single and sometimes…

Computation and Language · Computer Science 2023-01-10 Ziqi Zhang , Tomas Jasaitis , Richard Freeman , Rowida Alfrjani , Adam Funk

Text is the most widely used means of communication today. This data is abundant but nevertheless complex to exploit within algorithms. For years, scientists have been trying to implement different techniques that enable computers to…

Machine Learning · Statistics 2020-10-02 Antoine Ly , Benno Uthayasooriyar , Tingting Wang

As part of the SMILK Joint Lab, we studied the use of Natural Language Processing to: (1) enrich knowledge bases and link data on the web, and conversely (2) use this linked data to contribute to the improvement of text analysis and the…

Information Retrieval · Computer Science 2019-01-09 Cédric Lopez , Molka Dhouib , Elena Cabrio , Catherine Faron Zucker , Fabien Gandon , Frédérique Segond

Recent advances in large language models (LLMs) have highlighted the effectiveness of chain-of-thought reasoning in symbolic domains such as mathematics and programming. However, our study shows that directly transferring such text-based…

Artificial Intelligence · Computer Science 2026-03-06 Chuanliu Fan , Zicheng Ma , Huanran Meng , Aijia Zhang , Wenjie Du , Jun Zhang , Yi Qin Gao , Ziqiang Cao , Guohong Fu

The global demand for sustainable protein sources has accelerated the need for intelligent tools that can rapidly process and synthesise domain-specific scientific knowledge. In this study, we present a proof-of-concept multi-agent…

Artificial Intelligence · Computer Science 2025-06-26 Alexander D. Kalian , Jaewook Lee , Stefan P. Johannesson , Lennart Otte , Christer Hogstrand , Miao Guo

Unlocking the next generation of biotechnology and therapeutic innovation demands overcoming the inherent complexity and resource-intensity of conventional protein engineering methods. Recent GenAI-powered computational techniques often…

Text matching is a fundamental technique in both information retrieval and natural language processing. Text matching tasks share the same paradigm that determines the relationship between two given texts. The relationships vary from task…

Information Retrieval · Computer Science 2022-08-23 Shicheng Xu , Liang Pang , Huawei Shen , Xueqi Cheng

The structural similarities between protein sequences and natural languages have led to parallel advancements in deep learning across both domains. While large language models (LLMs) have achieved much progress in the domain of natural…

Biomolecules · Quantitative Biology 2024-08-29 Yiqing Shen , Zan Chen , Michail Mamalakis , Yungeng Liu , Tianbin Li , Yanzhou Su , Junjun He , Pietro Liò , Yu Guang Wang

Extracting information from documents usually relies on natural language processing methods working on one-dimensional sequences of text. In some cases, for example, for the extraction of key information from semi-structured documents, such…

Computation and Language · Computer Science 2021-06-29 Oliver Bensch , Mirela Popa , Constantin Spille

The need for raw large raw corpora has dramatically increased in recent years with the introduction of transfer learning and semi-supervised learning methods to Natural Language Processing. And while there have been some recent attempts to…

Computation and Language · Computer Science 2022-01-19 Julien Abadji , Pedro Ortiz Suarez , Laurent Romary , Benoît Sagot

Identifying interactions between proteins is important to understand underlying biological processes. Extracting a protein-protein interaction (PPI) from the raw text is often very difficult. Previous supervised learning methods have used…

Quantitative Methods · Quantitative Biology 2018-08-10 Mahtab Ahmed , Jumayel Islam , Muhammad Rifayat Samee , Robert E. Mercer

Protein research is crucial in various fundamental disciplines, but understanding their intricate structure-function relationships remains challenging. Recent Large Language Models (LLMs) have made significant strides in comprehending…

Computational Engineering, Finance, and Science · Computer Science 2025-01-24 Chao Wang , Hehe Fan , Ruijie Quan , Yi Yang

Digital modeling of the microstructure is important for studying the physical and transport properties of porous media. Multiscale modeling for porous media can accurately characterize macro-pores and micro-pores in a large-FoV (field of…

Image and Video Processing · Electrical Eng. & Systems 2023-05-03 Pengcheng Yan , Qizhi Teng , Xiaohai He , Zhenchuan Ma , Ningning Zhang

When describing images with natural language, the descriptions can be made more informative if tuned using downstream tasks. This is often achieved by training two networks: a "speaker network" that generates sentences given an image, and a…

Computer Vision and Pattern Recognition · Computer Science 2019-07-29 Gilad Vered , Gal Oren , Yuval Atzmon , Gal Chechik

Deep neural-network-based language models (LMs) are increasingly applied to large-scale protein sequence data to predict protein function. However, being largely black-box models and thus challenging to interpret, current protein LM…

Quantitative Methods · Quantitative Biology 2024-08-06 Mai Ha Vu , Rahmad Akbar , Philippe A. Robert , Bartlomiej Swiatczak , Victor Greiff , Geir Kjetil Sandve , Dag Trygve Truslew Haug

Self-supervised training of language models (LMs) has seen great success for protein sequences in learning meaningful representations and for generative drug design. Most protein LMs are based on the Transformer architecture trained on…

Biomolecules · Quantitative Biology 2025-04-03 Yingheng Wang , Zichen Wang , Gil Sadeh , Luca Zancato , Alessandro Achille , George Karypis , Huzefa Rangwala

The sheer amounts of biological data that are generated in recent years have driven the development of network analysis tools to facilitate the interpretation and representation of these data. A fundamental challenge in this domain is the…

Quantitative Methods · Quantitative Biology 2013-07-31 Arnon Mazza , Irit Gat-Viks , Hesso Farhan , Roded Sharan
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