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Unsupervised word segmentation methods were applied to analyze the protein sequence. Protein sequences, such as 'MTMDKSELVQKA...', were used as input to these methods. Segmented 'protein word' sequences, such as 'MTM DKSE LVQKA', were then…

Computational Engineering, Finance, and Science · Computer Science 2015-10-29 Wang Liang , Zhao KaiYong

Text preprocessing is an essential step in text mining. Removing words that can negatively impact the quality of prediction algorithms or are not informative enough is a crucial storage-saving technique in text indexing and results in…

Information Retrieval · Computer Science 2020-12-07 Farah Alshanik , Amy Apon , Alexander Herzog , Ilya Safro , Justin Sybrandt

This paper presents a self-supervised learning method for pointer-generator networks to improve spoken-text normalization. Spoken-text normalization that converts spoken-style text into style normalized text is becoming an important…

Computation and Language · Computer Science 2021-02-17 Mana Ihori , Naoki Makishima , Tomohiro Tanaka , Akihiko Takashima , Shota Orihashi , Ryo Masumura

Natural Language Processing (NLP) systems often make use of machine learning techniques that are unfamiliar to end-users who are interested in analyzing clinical records. Although NLP has been widely used in extracting information from…

Human-Computer Interaction · Computer Science 2017-07-10 Gaurav Trivedi , Phuong Pham , Wendy Chapman , Rebecca Hwa , Janyce Wiebe , Harry Hochheiser

Many advances in Natural Language Processing have been based upon more expressive models for how inputs interact with the context in which they occur. Recurrent networks, which have enjoyed a modicum of success, still lack the…

Computation and Language · Computer Science 2020-01-30 Gábor Melis , Tomáš Kočiský , Phil Blunsom

The impressive capabilities of large language models (LLMs) have sparked debate over whether these models genuinely generalize to unseen tasks or predominantly rely on memorizing vast amounts of pretraining data. To explore this issue, we…

Computation and Language · Computer Science 2025-03-04 Xinyi Wang , Antonis Antoniades , Yanai Elazar , Alfonso Amayuelas , Alon Albalak , Kexun Zhang , William Yang Wang

We use commercially available text analysis technology to process interview text data from a computational social science study. We find that topical clustering and terminological enrichment provide for convenient exploration and…

Computation and Language · Computer Science 2020-12-01 Jussi Karlgren , Renee Li , Eva M Meyersson Milgrom

In this paper, we present a novel approach to knowledge extraction and retrieval using Natural Language Processing (NLP) techniques for material science. Our goal is to automatically mine structured knowledge from millions of research…

Computation and Language · Computer Science 2023-02-14 Xianjun Yang , Stephen Wilson , Linda Petzold

Understanding biological processes, drug development, and biotechnological advancements requires a detailed analysis of protein structures and functions, a task that is inherently complex and time-consuming in traditional protein research.…

Artificial Intelligence · Computer Science 2025-04-21 Yijia Xiao , Edward Sun , Yiqiao Jin , Qifan Wang , Wei Wang

Proteins, essential to biological systems, perform functions intricately linked to their three-dimensional structures. Understanding the relationship between protein structures and their amino acid sequences remains a core challenge in…

Quantitative Methods · Quantitative Biology 2024-11-04 Liang He , Peiran Jin , Yaosen Min , Shufang Xie , Lijun Wu , Tao Qin , Xiaozhuan Liang , Kaiyuan Gao , Yuliang Jiang , Tie-Yan Liu

Automatically extracting Protein-Protein Interactions (PPI) from biomedical literature provides additional support for precision medicine efforts. This paper proposes a novel memory network-based model (MNM) for PPI extraction, which…

Computation and Language · Computer Science 2020-01-08 Huiwei Zhou , Zhuang Liu , Shixian Ning , Yunlong Yang , Chengkun Lang , Yingyu Lin , Kun Ma

State-of-the-art methods for protein-protein interaction (PPI) extraction are primarily feature-based or kernel-based by leveraging lexical and syntactic information. But how to incorporate such knowledge in the recent deep learning methods…

Computation and Language · Computer Science 2017-06-08 Yifan Peng , Zhiyong Lu

Protein-protein interaction (PPI) extraction from published scientific literature provides additional support for precision medicine efforts. Meanwhile, knowledge bases (KBs) contain huge amounts of structured information of protein…

Computation and Language · Computer Science 2019-12-12 Huiwei Zhou , Xuefei Li , Weihong Yao , Zhuang Liu , Shixian Ning , Chengkun Lang , Lei Du

Several complex systems are characterized by presenting intricate characteristics taking place at several scales of time and space. These multiscale characterizations are used in various applications, including better understanding…

Computation and Language · Computer Science 2023-05-12 Bárbara C. e Souza , Filipi N. Silva , Henrique F. de Arruda , Giovana D. da Silva , Luciano da F. Costa , Diego R. Amancio

Learning language of protein sequences, which captures non-local interactions between amino acids close in the spatial structure, is a long-standing bioinformatics challenge, which requires at least context-free grammars. However, complex…

Formal Languages and Automata Theory · Computer Science 2019-03-20 Witold Dyrka , François Coste , Juliette Talibart

Text matching is a core natural language processing research problem. How to retain sufficient information on both content and structure information is one important challenge. In this paper, we present a neural approach for general-purpose…

Computation and Language · Computer Science 2020-03-26 Xixi Zhou , Chengxi Li , Jiajun Bu , Chengwei Yao , Keyue Shi , Zhi Yu , Zhou Yu

Recent advances in Protein Language Models (PLMs) have transformed protein engineering, yet unlike their counterparts in Natural Language Processing (NLP), current PLMs exhibit a fundamental limitation: they excel in either Protein Language…

Computational Engineering, Finance, and Science · Computer Science 2025-09-16 Liuzhenghao Lv , Zongying Lin , Hao Li , Yuyang Liu , Jiaxi Cui , Calvin Yu-Chian Chen , Li Yuan , Yonghong Tian

While Multimodal Large Language Models (MLLMs) excel at generalizing across modalities and tasks, effectively adapting them to specific downstream tasks while simultaneously retaining both general and specialized knowledge remains…

Computer Vision and Pattern Recognition · Computer Science 2025-03-24 Jian Liang , Wenke Huang , Guancheng Wan , Qu Yang , Mang Ye

Identification of protein-protein interactions (PPIs) helps derive cellular mechanistic understanding, particularly in the context of complex conditions such as neurodegenerative disorders, metabolic syndromes, and cancer. Large Language…

Machine Learning · Computer Science 2025-08-18 Sanket Jantre , Tianle Wang , Gilchan Park , Kriti Chopra , Nicholas Jeon , Xiaoning Qian , Nathan M. Urban , Byung-Jun Yoon

Designing proteins that satisfy natural language functional requirements is a central goal in protein engineering. A straightforward baseline is to fine-tune generic instruction-tuned LLMs as direct text-to-sequence generators, but this is…

Quantitative Methods · Quantitative Biology 2026-04-21 Yutang Ge , Guojiang Zhao , Sihang Li , Zheng Cheng , Zifeng Zhao , Hanchen Xia , Guolin Ke , Linfeng Zhang , Zhifeng Gao , Yuguang Wang