English

Identifying Protein-Protein Interaction using Tree LSTM and Structured Attention

Quantitative Methods 2018-08-10 v1 Computation and Language Information Retrieval Machine Learning

Abstract

Identifying interactions between proteins is important to understand underlying biological processes. Extracting a protein-protein interaction (PPI) from the raw text is often very difficult. Previous supervised learning methods have used handcrafted features on human-annotated data sets. In this paper, we propose a novel tree recurrent neural network with structured attention architecture for doing PPI. Our architecture achieves state of the art results (precision, recall, and F1-score) on the AIMed and BioInfer benchmark data sets. Moreover, our models achieve a significant improvement over previous best models without any explicit feature extraction. Our experimental results show that traditional recurrent networks have inferior performance compared to tree recurrent networks for the supervised PPI problem.

Keywords

Cite

@article{arxiv.1808.03227,
  title  = {Identifying Protein-Protein Interaction using Tree LSTM and Structured Attention},
  author = {Mahtab Ahmed and Jumayel Islam and Muhammad Rifayat Samee and Robert E. Mercer},
  journal= {arXiv preprint arXiv:1808.03227},
  year   = {2018}
}

Comments

9 Pages, 2 Figures, Under Review

R2 v1 2026-06-23T03:29:05.598Z