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The combination of the catechol-containing co-monomer dopamine methacrylamide (DMA) with stimuli-responsive microgels such as poly(N-isopropylacrylamide) (PNIPAM) bears a huge potential in research and for applications due to the versatile…
The motility of eukaryotic cells is strongly influenced by their environment, with confined cells often developing qualitatively different motility patterns from those migrating on simple two-dimensional substrates. Recent experiments,…
Basic understanding of biological membranes is of paramount importance as these membranes comprise the very building blocks of life itself. Cells depend in their function on a range of properties of the membrane, which are important for the…
We report x-ray total scattering and pair distribution function (PDF) studies of the structural relaxation around interstitial manganese (Mn$_i$) in ferromagnetic Mn$_{1+\delta}$Sb ($0.03 \le \delta \le 0.23$) alloys, guided by density…
DNA methylation (meDNA) is a suspected modulator of alternative splicing, while splicing in turn is involved in tumour formations nearly as frequently as DNA mutations. Yet, the impact of meDNA on tumorigenesis via its effect on splicing…
Huntington's disease (HD) is an inherited neurodegenerative disorder caused by an expanded CAG repeat in the coding sequence of the huntingtin protein. Initially, it predominantly affects medium-sized spiny neurons (MSSNs) of the corpus…
Axon diameter and myelin thickness affect the conduction velocity of action potentials in the nervous system. Imaging them non-invasively with MRI-based methods is thus valuable for studying brain microstructure and function. Electron…
Models of the cortico-basal ganglia network and volume conductor models of the brain can provide insight into the mechanisms of action of deep brain stimulation (DBS). In this study, the coupling of a network model, under parkinsonian…
Mouse prion protein PrP106-126 is a peptide corresponding to the residues 107-127 of human prion protein. It has been shown that PrP106-126 can reproduce the main neuropathological features of prionrelated transmissible spongiform…
We describe a large-scale functional brain model that includes detailed, conductance-based, compartmental models of individual neurons. We call the model BioSpaun, to indicate the increased biological plausibility of these neurons, and…
Malignant membranes cluster nutrient transporters within glycan-rich domains, sustaining metabolism through redundant intake routes. A theoretical framework links interfacial chemistry to transport suppression and energetic or redox…
Although several ADAMs (A disintegrin-like and metalloproteases) have been shown to contribute to the amy-loid precursor protein (APP) metabolism, the full spectrum of metalloproteases involved in this metabolism remains to be established.…
Avian prestin is sensitive to membrane thickness as much as mammalian prestin, which undergoes conformational transitions in membrane area and thereby drives length changes of the cylindrical cell body of outer hair cells. The membrane…
NMDA receptors are ion channels activated by the neurotransmitter glutamate in the mammalian brain and are important in synaptic function and plasticity, but are also found in extrasynaptic locations and influence neuronal excitability.…
The mechanism of threshold elongation (overstretching) of DNA macromolecules under the action of external force is studied within the framework of phenomenological approach. When considering the task it is taken into account that…
In clathrin-mediated endocytosis (CME), clathrin and various adaptor proteins coat a patch of the plasma membrane, which is reshaped to form a budded vesicle. Experimental studies have demonstrated that elevated membrane tension can inhibit…
Metasurface coupling constitutes a fundamental yet intricate electromagnetic interaction that occurs within a lattice of artificial subwavelength unit cells. Despite its prevalence, such coupling is typically ignored in conventional…
Global and local linear gyrokinetic simulations of 42 pedestal equilibria from three DIII-D discharges are used to investigate pedestal stability and its impact on pedestal structure and confinement. Microtearing modes (MTMs) and kinetic…
In biological tissue, MR transverse relaxation stems from mechanisms spanning multiple scales, from molecular dipole-dipole interactions to mesoscopic field variations driven by tissue microstructure. While mesoscopic relaxation reflects…
Deep Brain Stimulation (DBS) is an established and powerful treatment method in various neurological disorders. It involves chronically delivering electrical pulses to a certain stimulation target in the brain in order to alleviate the…