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The interaction of targeted drug carriers with epithelial and endothelial barriers in vivo is largely determined by the dynamics of the body fluids. To simulate these conditions in binding assays, a fully biocompatible in vitro model was…

Biological cells sense and respond to mechanical forces, but how such a mechanosensing proccess takes place in a nonlinear inhomogeneous fibrous matrix remains unknown. We show that cells in a fibrous matrix induce deformation fields that…

Biological Physics · Physics 2015-06-10 Jacob Notbohm , Ayelet Lesman , Phoebus Rosakis , David A. Tirrell , Guruswami Ravichandran

Though ubiquitous in many engineering applications, including drug delivery, the compound droplet hydrodynamics in confined geometries have been barely surveyed. For the first time, this study thoroughly investigates the hydrodynamics of a…

The model of the deformation of DNA macromolecule is developed with the accounting of two types of components of deformation: external and internal. External components describe the bend, twist and stretch of the double helix. The internal…

Soft Condensed Matter · Physics 2020-12-01 P. P. Kanevska , S. N. Volkov

The formation of amyloid fibrils comprising amyloid $\beta$ (A$\beta$) peptides is associated with the pathology of Alzheimer's disease. In this study, we theoretically investigated the A$\beta$ structure at the fibril end using the density…

Biological Physics · Physics 2025-05-15 Yasuhiro Oishi , Motoharu Kitatani , Kichitaro Nakajima , Hirotsugu Ogi , Koichi Kusakabe

We present a study investigating the role of mitochondrial variability in generating noise in eukaryotic cells. Noise in cellular physiology plays an important role in many fundamental cellular processes, including transcription,…

Cell Behavior · Quantitative Biology 2015-05-28 Iain G. Johnston , Bernadett Gaal , Ricardo Pires das Neves , Tariq Enver , Francisco J. Iborra , Nick S. Jones

We report a theoretical low-field magnetotransport study unveiling the effect of pseudospin in realistic models of weakly disordered graphene-based materials. Using an efficient Kubo computational method, and simulating the effect of…

Mesoscale and Nanoscale Physics · Physics 2016-03-11 Frank Ortmann , Alessandro Cresti , Gilles Montambaux , Stephan Roche

In growing plant cells, parallel ordering of microtubules (MTs) along the inner surface of the cell membrane influences the direction of cell expansion and thereby plant morphology. For correct expansion of organs that primarily grow by…

Biological Physics · Physics 2019-09-05 Sven Bachmann , Richard Froese , Eric N Cytrynbaum

Biological cells are able to adapt their behaviour in response to environmental cues. Durotaxis is a phenomenon in which cells adjust their migration depending on the mechanical properties of a surrounding substrate. Although durotaxis has…

Biological Physics · Physics 2026-05-11 Sohei Nakamura , Mitsusuke Tarama

Doubly-stochastic matrices (DSM) are increasingly utilized in structure-preserving deep architectures -- such as Optimal Transport layers and Sinkhorn-based attention -- to enforce numerical stability and probabilistic interpretability. In…

Machine Learning · Computer Science 2026-01-06 Yizhi Liu

Animal cells in tissues are supported by biopolymer matrices, which typically exhibit highly nonlinear mechanical properties. While the linear elasticity of the matrix can significantly impact cell mechanics and functionality, it remains…

A functional heterostructure is central to integrated circuitry in quantum photonics, optoelectronics, neuromorphic computing, spintronics, and straintronics. Recently, heterostructures combining 2D magnets and nonmagnetic transition metal…

Strongly Correlated Electrons · Physics 2025-11-20 Swagata Acharya , Dimitar Pashov , Daphne Lubert-Perquel , Mark van Schilfgaarde , Justin C. Johnson

Interactions mediated by the cell membrane between inclusions, such as membrane proteins or antimicrobial peptides, play important roles in their biological activity. They also constitute a fascinating challenge for physicists, since they…

Biological Physics · Physics 2019-03-15 Anne-Florence Bitbol , Doru Constantin , Jean-Baptiste Fournier

The magnetic properties of metal-organic complexes are strongly influenced by conformational changes in the ligand. The flexibility of Fe-tetra-pyridyl-porphyrin molecules leads to different adsorption configurations on a Au(111) surface.…

Mesoscale and Nanoscale Physics · Physics 2018-11-06 Daniela Rolf , Christian Lotze , Constantin Czekelius , Benjamin W. Heinrich , Katharina J. Franke

Ultra-high field MRI offers unprecedented detail for non-invasive visualization of the human brain. However, brain imaging is challenging at 7T due to the B$_1^+$ field inhomogeneity, which results in signal intensity drops in temporal…

Medical Physics · Physics 2024-03-13 Vladislav Koloskov , Wyger Brink , Andrew Webb , Alena Shchelokova

How do solute concentration and molecular chemistry govern the transition from membrane saturation to destabilization? We address this using microsecond-scale molecular dynamics simulations of dipalmitoylphosphatidylcholine (DPPC) bilayers…

Soft Condensed Matter · Physics 2026-05-12 Anirban Polley

Diffractive neural networks leverage the high-dimensional characteristics of electromagnetic (EM) fields for high-throughput computing. However, the existing architectures face challenges in integrating large-scale multidimensional…

Optics · Physics 2025-09-09 Songtao Yang , Sheng Gao , Chu Wu , Zejia Zhao , Haiou Zhang , Xing Lin

If two DGP branes carry U(1) gauge theories and overlap, particles of one brane can interact with the photons from the other brane. This coupling modifies in particular the Coulomb potentials between charges from the same brane in the…

High Energy Physics - Theory · Physics 2015-06-23 Rainer Dick

In this paper, we have studied, within a discrete WLC model, the spatial constraints in magnetic tweezers used in single molecule experiments. Two elements are involved: first, the fixed plastic slab on which is stuck the initial strand,…

Biomolecules · Quantitative Biology 2009-11-13 C. Bouchiat

Convergence extension, the simultaneous elongation of tissue along one axis while narrowing along a perpendicular axis, occurs during embryonic development. A fundamental process that contributes to shaping the organism, it happens in many…

Soft Condensed Matter · Physics 2023-03-06 Aondoyima Ioratim-Uba , Tanniemola B. Liverpool , Silke Henkes