Other Quantitative Biology
We derive a charge conserving phase space cable equation for the propagating action potential, expressing ionic, capacitive and axoplasmic currents as functions of membrane potential. The new equation prediction of ionic current crossing…
This study presents a mathematical model formulated as a system of first-order non-linear ordinary differential equations, aimed at examining the effects of different factors, classified as local and systemic factors on a wound healing…
PF708 teriparatide, manufactured by Alvogen, was approved through the 505(B)(2) application after the expiration of Forteo market exclusivity in October 2019. The 505(B)(2) application allows safety and efficacy information to come from…
The spotted lanternfly is rapidly establishing itself as a major insect pest with global implications. Despite significant management efforts, its spread continues in invaded regions, and refined management strategies are required. A recent…
Adaptive humoral immunity, from the physical perspective, can be regarded as the self-organization of the binding energy landscape of antibodies. In biological terms, the humoral immune system evolves and adapts its repertoire of antigen…
Alongside molecular insights into genes and proteins, biological imaging holds great promise for deepening scientific understanding of complex cellular systems and advancing predictive, personalized therapies for human health. To realize…
All parts of the hawthorn tree (Crataegus spp.), including fruits, flowers, and leaves, have been used as a source of bioactive compounds. Thus, in this investigation, the twigs of two species of hawthorn plant of Crataegus azarolus (C.…
Citrus greening, or Huanglongbing (HLB), is a serious disease affecting citrus crops, with no known cure. Early detection is essential, but current methods are often expensive. To address this, a low-cost, portable sensor was developed to…
Biomedical knowledge graphs (KGs) are widely used across research and translational settings, yet their design decisions and implementation are often opaque. Unlike ontologies that more frequently adhere to established creation principles,…
Mathematical models of photosynthesis-irradiance relationships in phytoplankton are used to compute integrated water-column photosynthetic rates and predict primary production. Models typically ignore an important phenomenon observed in…
We present a stochastic differential equation model of suicidal progression in U.S. veterans, simulating transitions across mental health states under dynamic stress and covariate influence. Transition rates are modulated by an…
Visual impairment impacts more than 2.2 billion people worldwide, and it greatly restricts independent mobility and access. Conventional mobility aids - white canes and ultrasound-based intelligent canes - are inherently limited in the…
Plants, being sessile organisms, have evolved a variety of defense mechanisms to protect themselves from invaders such as pathogens, insects, and herbivores. One key strategy is the release of volatile organic compounds (VOCs) into the air,…
Coordinated collaboration is essential to realize the added value of and infrastructure requirements for global image data sharing in the life sciences. In this White Paper, we take a first step at presenting some of the most common use…
Bayesian optimization has become widely popular across various experimental sciences due to its favorable attributes: it can handle noisy data, perform well with relatively small datasets, and provide adaptive suggestions for sequential…
Progressive neurodegenerative diseases, including Alzheimer's disease (AD), multiple sclerosis (MS), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS), exhibit complex, nonlinear trajectories that challenge deterministic…
How could primordial life, before the evolution of genetic systems, adapt to fluctuating environments and achieve homeostasis? This study proposes a minimal, chemically plausible model where homeostasis emerges from a simple chemical…
The question of "what is life?" has challenged scientists and philosophers for centuries, producing an array of definitions that reflect both the mystery of its emergence and the diversity of disciplinary perspectives brought to bear on the…
Mathematical models of cardiac cell electrical activity include numerous parameters, making calibration to experimental data and individual-specific modeling challenging. This study applies Sobol sensitivity analysis, a global…
Chronic infection with hepatitis B virus (HBV) can lead to formation of abnormal nodular structures within the liver. To address how changes in liver anatomy affect overall virus-host dynamics, we developed within-host ordinary differential…