Other Quantitative Biology
Identification of dynamics underlying biochemical pathways of interest in oncology is a primary goal in current systems biology. Understanding structures and interactions that govern the evolution of such systems is believed to be a…
In Systems Biology there is a growing interest in the question, whether or not a given mathematical model can admit more than one steady state. As parameter values are often unknown or subject to a very high uncertainty, one is often…
A quantitative theory on the construction and the evolution of the genetic code is proposed. Through introducing the concept of mutational deterioration (MD) and developing a theoretical formalism on MD minimization we have proved: 1, the…
The tendencies described in this work were revealed in the course of examination of adenine and uracil distribution in the mRNA encoding sequence. The study also discusses the usage of codons occupied by the amino acid arginine in the table…
We present a completely new version of our arithmetic model of the standard genetic code and compute in a straightforward manner the exact numeric degeneracies of the five multiplets without any trick for the doublets and the sextets, as we…
The structure of the genetic code is discussed in formal terms. A rectangular table of the code ("the code matrix"), whose properties reveal its arithmetical content tagged with the information symbols in several notations. New parameters…
In this paper, we analyze the temporal evolution of the age-dependent force of infection and incidence of rubella, after the introduction of a very specific vaccination programme in a previously nonvaccinated population where rubella was in…
Litter decomposition is an important process in the global carbon cycle. It accounts for most of the heterotrophic soil respiration and results in formation of more stable soil organic carbon (SOC) which is the largest terrestrial carbon…
Computational time reversal imaging can be used to locate the position of multiple scatterers in a known background medium. Here, we discuss a sparse approximation method for computational time-reversal imaging. The method is formulated…
There are innumerable 'biological complexity measure's. While some patterns emerge from these attempts to represent biological complexity, a single measure to encompass the seemingly countless features of biological systems, still eludes…
We show that our recently published Arithmetic Model of the genetic code based on Godel Encoding is robust against symmetry transformations, specially Rumer s one U > G, A > C, and constitutes a link between the degeneracy structure and the…
The standard genetic code multiplet structure as well as the correct degeneracies, class by class, are all extracted from the (unique) number 23, the order of the permutation group of 23 objects.
The production of peroxide and superoxide is an inevitable consequence of aerobic metabolism, and while these particular "reactive oxygen species" (ROSs) can exhibit a number of biological effects, they are not of themselves excessively…
We address the problem of proteasomal protein translocation and introduce a new stochastic model of the proteasomal digestion (cleavage) of proteins. In this model we account for the protein translocation and the positioning of cleavage…
This paper presents the scientific body of knowledge behind the Human Biodynamics Engine (HBE), a human motion simulator developed on the concept of Euclidean motion group SE(3), with 270 active degrees of freedom, force-velocity-time…
Here we develop an approach to bio-structural robustness integrated with structure-function relationship in a unified conceptual and methodological framework, and envision its study using adequate computational and experimental methods. To…
We describe an affine transformation on the (CIE) color matching functions and map the spectral locus as a circle. We then homogenize the right circular cylinder erected by the circle, with respect to a normalizing plane and develop an…
The sensory contact model allows forming different psychopathological states (anxious depression, catalepsy, social withdrawal, pathological aggression, hypersensitivity, cognition disturbances, anhedonia, alcoholism etc.) produced by…
Human language and its governing rules present a number of analogies with the organization and structure of communication and information management in living organisms. This chapter will provide a short general introduction about grammar,…
Anhedonia is one of the key symptoms of depression in humans. Consumption of 1% sucrose solution supplemented with 0.2% vanillin was studied in two experimental contexts in male mice living under chronic social stress induced by daily…