Biological Physics
DNA nanotechnology is a unique field, where physics, chemistry, biology, mathematics, engineering, and materials science can elegantly converge. Since the original proposal of Nadrian Seeman, significant advances have been achieved in the…
Wood's increasing role as a structural resource in sustainable materials selection demands accurate characterization of its mechanical behavior. Its performance arises from a hierarchical structure, where the dominant load-bearing component…
Vector-borne diseases continue to pose a significant health threat globally with more than 3 billion people at risk each year. Despite some limitations, mechanistic dynamic models are a popular approach to representing biological processes…
Biological molecular machines convert free energy between different forms in cells, often at high efficiency. Optimal control theory provides a framework to elucidate design principles governing energetically efficient driving. Here, we use…
Neural tissues of the central nervous system are among the softest and most fragile in the human body, protected from mechanical perturbation by the skull and the spine. In contrast, the enteric nervous system is embedded in a compliant,…
The discipline of `theoretical biology' has been developing from its inception several decades ago almost in parallel with the advances in biology, so much so that the latter is often considered to be almost exclusively an empirical…
Cells produce RNA and proteins via molecular templating networks. We show that information transmission in such networks is bounded by functions of a simple thermodynamic property of the network, regardless of complexity. Surprisingly,…
There has been a recent surge of interest in understanding charge transport at atomic scales. The motivations are myriad, including understanding the conductance properties of peptides measured experimentally. In this study, we propose a…
We explore the relationship between sodium (Na$^+$) and potassium (K$^+$) gating variables in the 4-dimensional (4D) Hodgkin-Huxley (HH) electrophysiology model, and reducing its complexity by deriving new 3D and 2D models that maintain the…
Many biological processes can be thought of as the result of an underlying dynamics in which the system repeatedly undergoes distinct and abortive trajectories with the dynamical process only ending when some specific process, purpose,…
Magnetotactic bacteria (MTB) are a diverse group of microorganisms that are able to biomineralize magnetic nanoparticles. Most MTB remain uncultured, making population-level characterization from natural environments difficult. We report…
Biological active matter like the cytoskeleton or tissues are characterized by their ability to transform chemical energy into mechanical stress. In addition, it often exhibits orientational order, which is essential for many cellular and…
Marine ecosystems are in the spotlight, because environmental changes are threatening biodiversity and ecological functions. In this context, microalgae play key ecological roles both in planktonic and benthic ecosystems. Consequently, they…
The remarkable cohesion and coordination observed in moving animal groups and their collective responsiveness to threats are thought to be mediated by scale-free correlations, where changes in the behavior of one animal influence others in…
In vivo skin exhibits viscoelastic, hyper-elastic and non-linear characteristics. It is under a constant non-equibiaxial tension in its natural configuration and is reinforced with oriented collagen fibers, giving rise to anisotropic…
G protein-coupled receptors (GPCRs) represent a diverse and vital family of membrane proteins that mediate intracellular signaling in response to extracellular stimuli, playing critical roles in physiology and disease. Traditionally…
We demonstrate asymmetric enzyme kinetics of a biomolecular motor F1-ATPase between synthesis and hydrolysis of adenosine triphosphate (ATP). Our experiments show that ATP hydrolysis follows Michaelis-Menten kinetics, but ATP synthesis,…
It is widely recognized that biological collectives operate near criticality to amplify their capability of collective response. The peak in susceptibility near criticality renders these groups highly responsive to external stimuli. While…
The temperature distribution within cells, especially the debates on mitochondrial temperature, has recently attracted widespread attention. Some studies have claimed that the temperature of mitochondria can reach up to 50-53 degrees…
While the power stroke of myosin and the release of inorganic phosphate (Pi) play crucial roles in transforming ATP's chemical energy into mechanical work across diverse biological systems, the exact temporal relationship between these…