Biological Physics
We present an integrated modeling framework that combines the Generalized Stochastic Microdosimetric Model (GSM2), used to predict cell survival fractions, with MINAS-TIRITH, a fast and efficient Geant4 DNA-based tool for simulating…
Enhanced enzyme diffusion (EED), in which the diffusion coefficient of an enzyme transiently increases during catalysis, has been extensively reported experimentally. We numerically and analytically demonstrate that such enzymes can act as…
Biological systems, with many interacting components, face high-dimensional environmental fluctuations, ranging from diverse nutrient deprivations to toxins, drugs, and physical stresses. Yet, many biological control mechanisms are `simple'…
Navigation of microorganisms is controlled by internal processes ultimately sensitive to mechanical or chemical signaling encountered along the path. In many natural environments, such as porous soils or physiological ducts, motile species…
Increasing complications due to bacterial and viral infections require novel antimicrobial approaches. One emerging strategy is that based on catalysts able to selectively deliver reactive oxygen species (ROS) without leaching of other…
Discerning the neurotransmitter dysregulation is a hallmark of neurological disorders and diseases, including Alzheimer's, Parkinson's, and multiple sclerosis. The concentration of neurotransmitters in the synaptic cleft is particularly…
Melanosomes are organelles found in a wide variety of tissues throughout the animal kingdom. They contain a variety of biological molecules, but the dominant constituent is the pigment melanin, and many functions ascribed to melanosomes,…
Anomalous heat diffusion is investigated for biological tissues displaying a fractal structure and long-term thermal memory, which is modeled via a fractional derivative. For increasing values of the fractional derivation order, the tissue…
Tuning cell rearrangements is essential in collective cell movement that underlies cancer progression, wound repair, and embryonic development. A key question is how tissue material properties and morphology emerge from cellular factors…
Symmetry breaking is common in animal and human brains where the lack of asymmetry often perturbs behavioral and cognitive functions. In particular, the ubiquity of mirror-image confusion in young children, which often persists in dyslexia,…
In the past eighty years, the Goldman-Hodgkins-Katz (GHK) equation has been the gold-standard framework for interpreting countless biological and physiological experiments and simulations that involve ion transport in…
Bacterial biofilms play a significant role in various fields that impact our daily lives, from detrimental public health hazards to beneficial applications in bioremediation, biodegradation, and wastewater treatment. However,…
Microtubules (MTs) are dynamic protein filaments essential for intracellular organization and transport, particularly in long-lived cells such as neurons. The plus and minus ends of neuronal MTs switch between growth and shrinking phases,…
This study investigates the mechanical properties of colon cancer cells through Brillouin microscopy, focusing on the differentiation between wild-type (WT) and CRISPR-modified cells. Brillouin microspectroscopy, a non-invasive technique,…
How pigment distribution influences the cuticle density within a microscopic butterfly wing scale, and how both impact each scale's final reflected color, remains unknown. We use ptychographic X-ray computed tomography to quantitatively…
Pulmonary hypertension (PH) can lead to significant vascular remodeling, resulting in altered pulmonary blood flow. Estimating the patient-specific contributions of each remodeling event is necessary to optimize and individualize clinical…
Current biophysical models for transcriptionally active chromatin view this as a polymer with sticky sites, mimicking transcription units such as promoters and enhancers which interact via the binding of multivalent complexes of…
Trichomes, specialized hair-like structures on the surfaces of many plants, play a crucial role in defense against herbivorous insects. We investigated the biomechanics of type VI glandular trichomes in cultivated tomato (Solanum…
The initial version of the planned paper has gone through a major revision in 2025. First, the paper ended up growing a bit too long, and as a result of that, we decided to split it into two parts. The first part focuses on the model for…
Phototaxis, the process by which living organisms navigate toward optimal light conditions, is essential for motile photosynthetic microorganisms. Positive(negative) phototaxis denotes the motion directed towards(away from) the source of…