Biological Physics
We propose a novel computational framework leveraging hypergraph theory to analyse cancer stem cell markers (CSCMs) across multiple organs. Hypergraphs provide a robust representation of CSCM co-expression patterns, capturing their complex…
How thousands of microtubules and molecular motors self-organize into spindles remains poorly understood. By combining static, nanometer-resolution, large-scale electron tomography reconstructions and dynamic, optical-resolution, polarized…
Cyanobacteria require ultra-fast metabolic switching to maintain reducing power balance during environmental fluctuations. Glucose-6-phosphate dehydrogenase (G6PDH), catalyzing the rate-limiting step of the oxidative pentose phosphate…
Molecular adhesion plays a central role in many biological systems, yet existing methods to quantify adhesive strength often struggle to bridge the gap between single-molecule resolution and biologically relevant environments. Here, we…
The folding and structure of biomacromolecules depend on the 3D distributions of their constituents, which ultimately controls their functionalities and interactions with other biomacromolecules. Atom probe tomography (APT) with its…
The mechanical properties of arterial walls are critical for maintaining vascular function under pulsatile pressure and are closely linked to the development of cardiovascular diseases. Despite advances in imaging and elastography,…
Motion models (i.e., transition probability densities) are often deduced from fluorescence widefield tracking experiments by analyzing single-particle trajectories post-processed from data. This analysis immediately raises the question: To…
Biocompatible vaterite microspheres, renowned for their porous structure, are promising carriers for magnetic nanoparticles (MNPs) in biomedical applications such as targeted drug delivery and diagnostic imaging. Precise control over the…
Accurate modelling of nerve impulse propagation requires accounting for strong higher-order nonlinearities in membrane dynamics, as incorporated in the extended Heimburg-Jackson model. By introducing third- and fourth-order polynomial terms…
The transport of deformable self-propelling objects like bacteria, worms, snakes, and robots through heterogeneous environments is poorly understood. In this paper, we use experiment, simulation, and theory to study a snake-like robot as it…
Sweat secretion and evaporation from the skin dictate the human ability to thermoregulate and thermal comfort in hot environments and impact skin interactions with cosmetics, textiles, and wearable electronics or sensors. However, sweating…
A comprehensive understanding of heat transfer mechanisms in biological tissues is essential for the advancement of thermal therapeutic techniques and the development of accurate bioheat transfer models. Conventional models often fail to…
The disruption of protein structures by denaturants like urea is well studied, though its molecular mechanisms remain unclear. Using Molecular Dynamics (MD) simulations, we investigated how urea affects the structural stability of Bovine…
Since Charles Darwin's time, the study of climbing plants on a cylindrical stake has been the subject of numerous articles in plant biology. One of the main ideas for studying the coiling of an elastic plant stem is to consider the growth…
Objective: Hyperthermia (HT), characterized by elevated tissue temperatures above physiological levels, is a well-established radiosensitizer. When combined with radiotherapy (RT), forming thermoradiotherapy (TRT), a synergistic effect is…
Circulating tumor cells (CTCs) have crucial roles in the spread of tumors during metastasis. A decisive step is the extravasation of CTCs from the blood stream or lymph system, which depends on the ability of cells to attach to vessel…
Biomolecular condensates form by phase separation of biological polymers and have important functions in the cell $-$ functions that are inherently connected to their physical properties. A remarkable aspect of such condensates is that…
The three-dimensional organization of chromatin is thought to play an important role in controlling gene expression. Specificity in expression is achieved through the interaction of transcription factors and other nuclear proteins with…
External pressure significantly influences microcirculatory capillary blood flow, yet current studies lack quantitative modeling. This work proposes a nonlinear segmented coupling model between external pressure and capillary flow,…
In the past 40 years, single-molecule techniques have been rapidly developed and widely applied in numerous fields of biology researches, offering new insights that conventional biochemical assays cannot discover. In this review, to help…