Sequential recruitment and combinatorial assembling of multiprotein complexes in transcriptional activation
Cell Behavior
2007-05-23 v1 Molecular Networks
Abstract
In human cells, estrogenic signals induce cyclical association and dissociation of specific proteins with the DNA in order to activate transcription of estrogen-responsive genes. These oscillations can be modeled by assuming a large number of sequential reactions represented by linear kinetics with random kinetic rates. Application of the model to experimental data predicts robust binding sequences in which proteins associate with the DNA at several different phases of the oscillation. Our methods circumvent the need to derive detailed kinetic graphs, and are applicable to other oscillatory biological processes involving a large number of sequential steps.
Keywords
Cite
@article{arxiv.q-bio/0605049,
title = {Sequential recruitment and combinatorial assembling of multiprotein complexes in transcriptional activation},
author = {Vincent Lemaire and Chiu Fan Lee and Jinzhi Lei and Raphael Metivier and Leon Glass},
journal= {arXiv preprint arXiv:q-bio/0605049},
year = {2007}
}