Using a variant of parallel tempering, we study the changes in sampling within a simulation when the all-atom model is coupled to a Go-like potential. We find that the native structure is not the lowest-energy configuration in the all-atom force field. Adding a Go-term deforms the energy landscape in a way that the native configuration becomes the global minimum.
Cite
@article{arxiv.0908.0419,
title = {Protein simulations combining an all-atom force field with a Go term},
author = {Jan H Meinke and Ulrich H E Hansmann},
journal= {arXiv preprint arXiv:0908.0419},
year = {2009}
}