Optical Diffraction Tomography Meets Fluorescence Localization Microscopy
Signal Processing
2023-07-19 v1 Optics
Abstract
We show that structural information can be extracted from single molecule localization microscopy (SMLM) data. More precisely, we reinterpret SMLM data as the measures of a phaseless optical diffraction tomography system for which the illumination sources are fluorophores within the sample. Building upon this model, we propose a joint optimization framework to estimate both the refractive index map and the position of fluorescent molecules from the sole SMLM frames.
Cite
@article{arxiv.2307.09261,
title = {Optical Diffraction Tomography Meets Fluorescence Localization Microscopy},
author = {Thanh-An Pham and Emmanuel Soubies and Ferréol Soulez and Michael Unser},
journal= {arXiv preprint arXiv:2307.09261},
year = {2023}
}
Comments
Presented in ISCS23