Nucleation and growth in one dimension, part II: Application to DNA replication kinetics
Soft Condensed Matter
2016-10-25 v1 Statistical Mechanics
Abstract
Inspired by recent experiments on DNA replication, we apply a one-dimensional nucleation-and-growth model to DNA-replication kinetics, focusing on how to extract the time-dependent nucleation rate I(t) and growth speed v from data. We discuss generic experimental problems, namely spatial inhomogeneity, measurement noise, and finite-size effects. After evaluating how each of these affects the measurements of I(t) and v, we give guidelines for the design of experiments. These ideas are then discussed in the context of the DNA-replication experiments.
Keywords
Cite
@article{arxiv.cond-mat/0408297,
title = {Nucleation and growth in one dimension, part II: Application to DNA replication kinetics},
author = {Suckjoon Jun and John Bechhoefer},
journal= {arXiv preprint arXiv:cond-mat/0408297},
year = {2016}
}
Comments
8 pages, 6 figures