Kinetic model of DNA replication in eukaryotic organisms
Abstract
We formulate a kinetic model of DNA replication that quantitatively describes recent results on DNA replication in the in vitro system of Xenopus laevis prior to the mid-blastula transition. The model describes well a large amount of different data within a simple theoretical framework. This allows one, for the first time, to determine the parameters governing the DNA replication program in a eukaryote on a genome-wide basis. In particular, we have determined the frequency of origin activation in time and space during the cell cycle. Although we focus on a specific stage of development, this model can easily be adapted to describe replication in many other organisms, including budding yeast.
Keywords
Cite
@article{arxiv.physics/0101087,
title = {Kinetic model of DNA replication in eukaryotic organisms},
author = {John Herrick and Suckjoon Jun and John Bechhoefer and Aaron Bensimon},
journal= {arXiv preprint arXiv:physics/0101087},
year = {2018}
}
Comments
10 pages, 6 figures: see also cond-mat/0306546 & physics/0306156