This work presents the implementation of a new charge detection mass spectrometer (CDMS) design that operates in a stand-alone mode, thanks to its integration with nanoelectrospray ionization. More specifically, this innovative CDMS consists of a linear charge detection array ion trap spectrometer that combines an eight-tube detector array with conical electrodes. This configuration allows for recording data in both transmission mode (linear array) and ion trapping mode (ConeArrayTrap), which enables the measurement of time-of-flight (related to the mass-to-charge ratio) along with the charge of individual ions. As a result, this design supports high-throughput metrology of viruses at the single-particle level. The devices and geometry of the instrument have been developed based on ion optics simulations. The performance of the current instrument is demonstrated using human norovirus-like particles (hNoVLP) and Adenovirus Ad(5) (hAdV5).
@article{arxiv.2506.01593,
title = {Nanoelectrospray ionization coupled to a linear charge detection array ion trap spectrometer for single viral particles analysis},
author = {S. Maclot and T. Reinert and L. Duplantier and G. Montagne and C. Clavier and X. Dagany and C. Comby-Zerbino and M. Kerleroux and L. Thiede and R. Pogan and C. Uetrecht and A. N. Kozhinov and K. O. Nagornov and Y. O. Tsybin and D. Papanastasiou and R. Antoine},
journal= {arXiv preprint arXiv:2506.01593},
year = {2025}
}